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Pharmacological activities of Borassus flabellifer L. extracts and isolated compounds

Yıl 2021, Cilt: 5 Sayı: 2, 23 - 31, 15.12.2021

Öz

OBJECTIVE: The purpose of this systematic review work is to evaluate, summarize, and document the scientific findings of the pharmacological activities of this plant species.

MATERIALS AND METHODS: The major electronic databases (Web of Science, Scopus, ScienceDirect, and PubMed) have been employed to identify related publications published from 1900 to July 2021. In this review, only reported pharmacological activities-related publications were considered to extract the data.

Results: Various parts of this plant species are used to treat various disorders in traditional medicines including various pulmonary complaints, diabetes, and heartburn. Further, compounds such as borassoside A to F, nicotinamide, and uracil have been isolated from various parts of B. flabellifer. Clinical, in vivo, and in vitro pharmacological scientific evidence is currently available, and various parts of B. flabellifer showed antiarthritic, anticancer, antipyretic, hypersensitivity, and immunomodulatory activities. Flower showed the greatest number of pharmacological activities. Hitherto, seven bioactive compounds have been identified from B. flabellifer. Only, some uses of B. flabellifer in traditional medicine have scientific evidence at the moment.

Conclusion: This review article summarized the available scientific evidence based on pharmacological activities of B. flabellifer. The importance and benefits of this plant species are known for a limited group of people and the significance of B. flabellifer should be understood to sustain this invaluable resource.

Destekleyen Kurum

Not Applicable

Proje Numarası

Not Applicable

Teşekkür

This work received no funding. The authors are grateful to their family members for their support to deliver this work.

Kaynakça

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Yıl 2021, Cilt: 5 Sayı: 2, 23 - 31, 15.12.2021

Öz

Proje Numarası

Not Applicable

Kaynakça

  • 1. Kew Science. Plants of the world online, Borassus flabellifer L. 2021. Available from: http://www.plantsoftheworldonline.org/taxon/urn:lsid:ipni.org:names:664873-1. Accessed on 10.03.2021
  • 2. Blombery A, Rodd T. 1992. Palms of the World. Angus and Robertson Publication
  • 3. Facciola S. Cornucopia II: A Source Book of Edible Plants. Kampong Publications. 1998. Available from: https://books.google.lk/books?id=XzolAQAAMAAJ. Accessed on 02.04.2021
  • 4. Pramod HJ, Yadav AV, Raje VN, Madhuri M, Ganesh W. Antioxidant activity of Borassus flabellifer (Linn.) fruits. Asian J Pharm Tech. 2013; 3 (1): 16-19.
  • 5. World agroforestry center. 2021. Available from: http://www.worldagroforestry.org/. Accessed on 02.04.2021
  • 6. Uphof JC. Dictionary of economic plants. H.R. Engelmann, J. Cramer. 1959. Available from: https://books.google.lk/books?id=iYMQtAEACAAJ. Accessed on 02.04.2021
  • 7. Digital Compendium of Forestry Species of Cambodia. 2008. Available from: http://www.digitalspecies.blogspot.com. Accessed on 02.04.2021
  • 8. Arunachalam K, Saravanan S, Parimelazhagan T. Nutritional analysis and antioxidant activity of palmyrah (Borassus flabellifer L.) seed embryo for potential use as food source. Food Science and Biotechnology, 2011; 20 (1): 143–149. https://doi.org/10.1007/s10068-011-0020-y
  • 9. Khare C. Borassus flabellifer Linn. In: Khare C. (eds) Indian Medicinal Plants. Springer, New York, NY. 2007. https://doi.org/10.1007/978-0-387-70638-2_232
  • 10. Morton JF. Notes on distribution, propagation, and products of Borassus palms (Arecaceae). Econ Bot, 1988; 42 (3): 420-441.
  • 11. Vivekanandarajah S, Rajamanoharan PR, Heinrich M, Munday M. Preparations and plants used to treat diabetes in Sri Lankan Siddha Medicine. Presented at the 3rd International Conference on Ayurveda, Unani, Siddha and Traditional Medicine, Institute of Indigenous Medicine, University of Colombo, Colombo. 2015; 67.
  • 12. Vivekanandarajah S, Rajamanoharan PRS, Munday M, Heinrich M. Plants used to treat diabetes in Sri Lankan Siddha Medicine – An ethnopharmacological review of historical and modern sources. Journal of Ethnopharmacology. 2016; 198: 531–599. https://doi.org/10.1016/j.jep.2016.07.053
  • 13. Vivekanandarajah S, Rajamanoharan P, Munday M, Heinrich M. Plants currently used to treat diabetes in Sri Lankan Siddha Medicine – an ethnobotanical survey in the Eastern Province. Presented at the World Congress Integrative Medicine & Health 2017: part three, Springer Nature, Berlin, Germany. 2017; 333. https://doi.org/10.1186/s12906-017-1784-2
  • 14. Vivekanandarajah S, Rajamanoharan PRS, Heinrich M. Siddha Medicine in Eastern Sri Lanka Today–Continuity and Change in the Treatment of Diabetes. Front. Pharmacol. 2018; 9: 1022. https://doi.org/10.3389/fphar.2018.01022
  • 15. Shamala D, Arseculeratne SN, Pathmanathan R, McKenzie IFC, Pang T. Suppression of cell-mediated immunity following oral feeding of mice with palmyrah (Borassus flabellifer L) flour. Aust. J. Exp. Biol. Med. Sci. 1985; 63: 371–379.
  • 16. Vengaiah PC, Ravindrababu D, Murthy GN, Prasad KR. Jaggery from Palmyrah palm (Borassus flabellifer L.)- present status and scope. Indian J Tradit Knowledge, 12 (4), 714-717.
  • 17. Kaladhar DSVGK, Siva Kishore N. (2010). Antimicrobial studies, biochemical and image analysis in Mirabilis jalapa. International Journal of Pharmacy & Technology. 2013; 2 (3): 683-693.
  • 18. Rajamanoharan, P., Vivekanandarajah, S. The role of honey in pediatric treatments in Sri Lankan Siddha Medicine. Uludag Bee Journal. 2021; 21: 83–90. https://doi.org/10.31467/uluaricilik.851567
  • 19. Vivekanandarajah S. Antidiabetic plants used by Sri Lankan Tamils. Jaffna Science Association Newsletter. 2021; 28 (3): 3.
  • 20. Vivekanandarajah S. நீரிழிவைக் கட்டுப்படுத்த இலங்கைத் தமிழர்கள் உபயோகித்த தாவரங்கள்- பகுதி: 1 (Plants used by Sri Lankan Tamils to manage diabetes – Part: 1). Valampurii Newspaper2021.
  • 21. Vivekanandarajah S. நீரிழிவைக் கட்டுப்படுத்த இலங்கைத் தமிழர்கள் உபயோகித்த தாவரங்கள்- பகுதி: 2 (Plants used by Sri Lankan Tamils to manage diabetes – Part: 2). Valampurii Newspaper2021.
  • 22. Vivekanandarajah S. நீரிழிவைக் கட்டுப்படுத்த இலங்கைத் தமிழர்கள் உபயோகித்த தாவரங்கள்- பகுதி: 3 (Plants used by Sri Lankan Tamils to manage diabetes – Part: 3). Valampurii Newspaper. 2021.
  • 23. Vivekanandarajah S. Plants historically used by Sri Lankan Tamils to treat diabetes. Presented at The International Dr. Safiye Ali Multidisciplinary Studies Congress in Health Sciences, İzmir, Turkey. 2021.
  • 24. Vivekanandarajah S. Plants used to treat diabetes in Sri Lankan Siddha Medicine (Ph.D. Thesis). University College London, London, UK. 2018.
  • 25. Vivekanandarajah S. Plants historically used to treat diabetes in Sri Lankan Siddha Medicine. Presented at the International Seminar & Exhibition on Phytopharmaceuticals: Emerging Challenges and Opportunities, Ooty, India. 2017.
  • 26. Vivekanandarajah S. Plants with Anti-Diabetes Mellitus Properties, 591, Appian Subramoniam, CRC Press (Taylor & Francis Group), Boca Raton (FL, USA). Journal of Ethnopharmacology. 2016; 191: 19–20. https://doi.org/10.1016/J.JEP.2016.06.031
  • 27. Reshma MV, Jacob J, Syamnath VL, Habeeba VP, Dileep Kumar BS, Lankalapalli RS. First report on isolation of 2,3,4-trihydroxy-5-methyl acetophenone from palmyra palm (Borassus flabellifer Linn.) syrup, its antioxidant and antimicrobial properties. Food Chemistry. 2017; 228: 491–496. https://doi.org/10.1016/j.foodchem.2017.02.043
  • 28. Revesz L, Hiestand P, Vecchia LLa, Naef R, Naegeli HU, Oberer L, Roth HJ. Isolation and synthesis of a novel immunosuppressive 17or-substituted dammarane from the flour of the palmyrah palm. Bioorganic & Medicinal Chemistry Letters. 1999; 9: 1521–1526.
  • 29. Yoshikawa MY, Fengming XU, Orikawa TM, Ongpiriyadacha YP. Medicinal Flowers . XII. 1) New Spirostane-Type Steroid Saponins with Antidiabetogenic Activity from Borassus flabellifer. 2007; 55 (2): 308–316.
  • 30. Jamkhande PG, Suryawanshi VA, Wattamwar AS, Barde SR. In vitro anthelmintic efficacy of Borassus flabellifer Linn. (Palmae) against Pheretima posthuma. Asian Pacific Journal of Tropical Disease, 2014; 4 (S1). https://doi.org/10.1016/S2222-1808(14)60439-4
  • 31. Paschapur MS, Patil MB, Kumar R, Patil SR. Evaluation of anti-inflammatory activity of ethanolic extract of Borassus flabellifer L. male flowers (inflorescences) in experimental animals. Journal of Medicinal Plants Research, 2009a; 3 (2): 049–054.
  • 32. Vijayakumari B, Vengaiah PC, Kiranmayi P. Qualitative phytochemical screening, GC-MS analysis and antibacterial activity of palmyra fruit pulp (Borassus flabellifer L.)". International Journal of Pharma and Bio Sciences. 2015; 6 (2): 430–435.
  • 33. Viju N, Punitha SMJ, Satheesh S. Antifouling Potential of Palmyra Palm (Borassus flabellifer) Fruit Husk Extract". Proceedings of the National Academy of Sciences India Section B - Biological Sciences. 2020; 90 (5): 1005–1015. https://doi.org/10.1007/s40011-020-01171-5
  • 34. Jamkhande PG, Suryawanshi VA, Kaylankar TM, Patwekar SL. Biological activities of leaves of ethnomedicinal plant, Borassus flabellifer Linn. (Palmyra palm): An antibacterial, antifungal and antioxidant evaluation. Bulletin of Faculty of Pharmacy, Cairo University, 2016; 54 (1): 59–66. https://doi.org/10.1016/j.bfopcu.2016.01.002
  • 35. Mariselvam R, Ignacimuthu S, Ranjitsingh AJA, Mosae SP. An insight into leaf secretions of Asian palmyra palm: A wound-healing material from nature. Materials Today: Proceedings. 2020. https://doi.org/10.1016/j.matpr.2020.05.393
  • 36. Duddukuri GR, Sastry YN, Kaladhar DSVGK, Rao KK, Chaitanya KK. In vitro antibacterial activity of organic solvent seed coat extracts of Borassus flabellifer Linn. Biosciences Biotechnology Research Asia. 2011; 8 (1): 295–299. https://doi.org/10.13005/bbra/859
  • 37. Nagendra Sastry Y, Jyothi Padmaja I, Rajeswara Rao P, Surya Kirani KRL, Dsvgk K, Sai Devi T, Parvathi T, Gangadhar H, Siva Kumar K, Govinda Rao D. In vitro dose-dependent study on anti-human pathogenic bacterial and free radical scavenging activities of methanolic seed coat extract of Borassus flabellifer L. Asian Journal of Pharmaceutical and Clinical Research. 2012; 5 (SUPPL 2): 83–86.
  • 38. Alamelumangai M, Dhanalakshmi J, Mathumitha M, Renganayaki RS, Muthukumaran P, Saraswathy N. In vitro studies on phytochemical evaluation and antimicrobial activity of Borassus flabellifer Linn against some human pathogens. Asian Pacific Journal of Tropical Medicine. 2014; 7 (S1): 182–185. https://doi.org/10.1016/S1995-7645(14)60228-5
  • 39. Hong EH, Heo EY, Song JH, et al. Trans-scirpusin A showed antitumor effects via autophagy activation and apoptosis induction of colorectal cancer cells. Oncotarget. 2017; 8 (25): 41401–41411. https://doi.org/10.18632/oncotarget.17388
  • 40. Susmita Das, Sukriti Das, Bratati De. In vitro Inhibition of Key Enzymes Related to Diabetes by the Aqueous Extracts of Some Fruits of West Bengal, India. Current Nutrition & Food Science. 2012; 8 (1), 19–24. https://doi.org/10.2174/157340112800269614
  • 41. Satish AK, Sunil SJ, Ravindra DH. Screening of an Ethanolic Extract of Borassus flabellifer Flowers for its Antidiabetic Experimental and Antioxidant Potential, JOURNAL OF NATURAL REMEDIES. 2016; 16 (1): 22–32. doi: 10.18311/jnr/2016/654.
  • 42. Duraipandiyan V, Balamurugan R, Al-Dhabi NA, et al. The down-regulation of PTP1B expression and attenuation of disturbed glucose and lipid metabolism using Borassus flabellifer (L) fruit methanol extract in high-fat diet and streptozotocin-induced diabetic rats. Saudi Journal of Biological Sciences. 2020; 27 (1): 433–440. https://doi.org/10.1016/j.sjbs.2019.11.004
  • 43. Akter M, Saiful Islam KM, Sarkar UR, et al. Investigation of anti-diabetic properties of Borassus flabellifer L. (roots) on type-2 diabetic rats. Pharmacologyonline. 2020; 1: 105–112.
  • 44. Debnath T, Radhakrishnan R, Gopal M, Talwar S, Nandakumar K. Hypoglycemic effects of alcoholic root extract of Borassus flabellifer (Linn.) in normal and diabetic rats. Pakistan Journal of Pharmaceutical Sciences. 2013; 26 (4): 673–679.
  • 45. Goyal P, Pharm M, Jain N, Singh GK, Nagori BP. Hypoglycemic activity of inflorescence of Borassus flabellifer extracts on blood glucose levels of streptozocin-induced diabetic rats. Iranian Journal of Pharmacology and Therapeutics. 2014; 13 (1): 30–34.
  • 46. Natarajan K, Sangeetha R. Evaluation of anti-inflammatory property of the roots of Borassus flabellifer. International journal of research in pharmaceutical sciences. 2019; 331–334. https://doi.org/https://doi.org/10.26452/ijrps.v11i1.1825
  • 47. Paschapur MS, Patil S, Patil SR, Kumar R, Patil MB. Evaluation of the analgesic and antipyretic activities of ethanolic extract of male flowers (inflorescences) of Borassus flabellifer L. (Arecaceae). International Journal of Pharmacy and Pharmaceutical Sciences. 2009; 2: 98–106.
  • 48. Paschapur MS, Patil MB, Kumar R, Patil SR. Influence of ethanolic extract of Borassus flabellifer L. male flowers (inflorescences) on chemically induced acute-inflammation and poly arthritis in rats. International Journal of PharmTech Research. 2009b; 1 (3): 551–556.
  • 49. Krishna Mohan C, Soundarya V, Vasanth Kumar R, Kiran Kumar L, Vamshi Sharathnath K, Narender B. In-Vitro Anti Inflammatory Activity of Dried Leaves of Borassus flabellifer. Iajps. 2016; 3 (8): 809–813.
  • 50. Jana S, Mukherjee S, Ali I, Ray B, Ray S. Isolation, structural features, in vitro antioxidant activity and assessment of complexation ability with β-lactoglobulin of a polysaccharide from Borassus flabellifer fruit. 2020; 6 (11): https://doi.org/10.1016/j.heliyon.2020.e05499
  • 51. Rodiah MH, Jamilah B, Sharifah Kharidah SM, Russly AR. Physico-chemical and antioxidant properties of mesocarp and exocarp from Borassus flabellifer. International Food Research Journal. 2019; 26 (5): 1469–1476.
  • 52. Wijewardana RMNA, Nawarathne SB, Wickramasinghe I, Gunawardane CR, Wasala WMCB, Thilakarathne BMKS. Retention of Physicochemical and Antioxidant Properties of Dehydrated Bael (Aegle Marmelos) and Palmyra (Borassus flabellifer) Fruit Powders. Procedia Food Science. 2016; 6 (Icsusl 2015): 170–175. https://doi.org/10.1016/j.profoo.2016.02.041
  • 53. Athinarayanan J, Periasamy VS, Qasem AA, Alshatwi AA. Borassus flabellifer biomass lignin: Isolation and characterization of its antioxidant and cytotoxic properties. Sustainable Chemistry and Pharmacy. 2018; 10 (October): 89–96. https://doi.org/10.1016/j.scp.2018.10.001
  • 54. Muthukumaran P, Sathishkumar T, Alamelumangai M, Dhanalakshmi J, Mathumitha M, Saranya renganayaki R. Extraction and Antioxidant Activity of Flavonoids from Seed Coat of Borassus flabellifer Linn using Orthogonal Array (L16(44)). Indian Journal of Pharmaceutical Sciences. 2018; 80 (1): 46-51. DOI: 10.4172/pharmaceutical-sciences.1000329.
  • 55. Sandhya J, Kalaiselvam S. Biogenic synthesis of magnetic iron oxide nanoparticles using inedible Borassus flabellifer seed coat: Characterization, antimicrobial, antioxidant activity and in vitro cytotoxicity analysis. Materials Research Express. 2020; 7 (1): 0–14. https://doi.org/10.1088/2053-1591/ab6642
  • 56. Singchai B, Kansane K, Chourykaew B. Phytochemical screening and biological activities of Borassus flabellifer L. Asian Journal of Pharmaceutical and Clinical Research, 8 (3), 151–153.
  • 57. Chinnaswamy PA, Nima KVB, Selvam KC. (2009). Diuretic effect of the ethanolic and aqueous extract of seedling. Asian Jr. of Microbiol. Biotec. Env. Sc. 2015; 11 (2): 313–317.
  • 58. Ma’Unatin A, Harijono, Zubaidah E, Rifa’I M. Immunomodulatory activity of exopolysaccharides produced by Leuconostoc mesenteroides strains isolated from palm (Borassus flabellifer L.) sap. IOP Conference Series: Earth and Environmental Science/ 2020; 456 (1): 6–11. https://doi.org/10.1088/1755-1315/456/1/012058
  • 59. Arseculeratne SN, Sirisinha S, Charupatana C, Kangwanpong D. Immunological Alterations in Rats Fed with Flour from the Palmyrah Palm (Borassus flabellifer L). Proceedings of the Society for Experimental Biology and Medicine. 1981; 168 (3): 356–360. https://doi.org/10.3181/00379727-168-41286
  • 60. Keerthi AAP, Mendis WSJ, Jansz ER, Ekanayake S, Perera MSA. A preliminary study on the effects of an antibacterial steroidal saponin from Borassus flabellifer L. fruit, on wound healing. Journal of the National Science Foundation of Sri Lanka. 2007; 35 (4): 263–265. https://doi.org/10.4038/jnsfsr.v35i4.1317
  • 61. Nadkarni KM, Nadkarni AK. (2000). Popular Prakashan; Bombay: Indian Materia Medica.
  • 62. Rahman, SS, Yasmin N, Kamruzzaman M, Islam MR, Karim MR, Rouf SM. Anti-hyperglycemic effect of the immature endosperm of sugar palm (Borassus flabellifer) fruit on type 2 diabetes mellitus patients-a case study. Diabetes and Metabolic Syndrome: Clinical Research and Reviews. 2020; 14 (5): 1317–1322. https://doi.org/10.1016/j.dsx.2020.06.055
  • 63. Suntini, Anastasia WI, Harjonoa. Novel composite of silver-bacterial (Borassus flabellifer) and its antibacterial activity. Jurnal Teknologi. 2021; 83 (1): 19–25.
Toplam 63 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Reviews
Yazarlar

Vinujan Shanmugalingam 0000-0002-9208-4090

Saravanan Vivekanandarajah Sathasivampillai 0000-0002-5938-0509

Srithayalan Srivijeindran 0000-0001-7276-8607

Proje Numarası Not Applicable
Yayımlanma Tarihi 15 Aralık 2021
Gönderilme Tarihi 12 Temmuz 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 5 Sayı: 2

Kaynak Göster

APA Shanmugalingam, V., Vivekanandarajah Sathasivampillai, S., & Srivijeindran, S. (2021). Pharmacological activities of Borassus flabellifer L. extracts and isolated compounds. International Journal of Innovative Research and Reviews, 5(2), 23-31.