Bir ben var benden içeri; Kimerizm

İlknur Keskin; Tangül Müdok

Bir ben var benden içeri; Kimerizm

Öz

ÖZET

Tıp literatüründe “Kimerizm” terimi, farklı organizmalara ait genetik yapıların bir arada bulunduğu, yeni, farklı ve ortak bir bütünü oluşturduğu durumları ifade etmek için kullanılır. Kimerik birey, kendi DNA’sının yanısıra dünyaya gelmeyenikizinin de DNA’sını taşır. Kaynaşma embriyo aşamasında iken gerçekleştiğinden dolayı, doku veya organ reddi olmaz. En sık ve doğal kimerizm sebebi gebeliktir..

Henüz cevap bulamamış sorular mevcut olmakla birlikte, başka faktörlerin de eklenmesi ile kimerizm’in insan sağlığında çok önemli bir yeri olduğu düşünülmektedir. Gerek otoimmün gerekse otoimmün olmayan hastalıklar ile olan yakın ilişkisi birçok çalışmaya konu konmuştur.

Anahtar Kelimeler

Kimerizm,Mikrokimerizm,Otoimmün hastalıklar,Prenatal tanı

Kaynakça

Tippet P. Blood group chimeras. A review. Vox Sang;1983;44:333-59.
Lapaire O, Holzgreve W, Oosterwijk JC, Brinkhaus R, Bianchi DW. Georg Schmorl on trophoblasts in the maternal circulation. Placenta. 2007;28(1):1-5.
Nelson JL. The otherness of self: microchimerism in health and disease. Trends Immunol. 2012;33(8):421-7.
Lo YM, Tein MS, Lau TK, Haines CJ, Leung TN, Poon PM, et al. Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis. Am J Hum Genet. 1998;62(4):768-75.
Price JO, Elias S, Wachtel SS, Klinger K, Dockter M, Tharapel A, et al. Prenatal diagnosis with fetal cells isolated from maternal blood by multiparameter flow cytometry. Am J Obstet Gynecol. 1991;165:1731-7.
Yunis EJ, Zuniga J, Romero V, Yunis EJ. Chimerism and tetragametic chimerism in humans: implications in autoimmunity, allorecognition and tolerance. Immunol Res. 2007;38(1-3):213-36.
Lambert NC, Dennis Lo YM, Erickson TD, Guthrie KA, Furst DE, et al. Male microchimerism in healthy women and women with scleroderma: cells or circulating DNA? A quantitative answer. Blood 2002; 100: 2845-51.
Flesland O, Pfeffer PF, Solheim BG, Mellbye OJ. Donor lymphocytes transferred with the graft to kidney recipients. Potential for establishing microchimerism. Transf Apher Sci 2003;28:125-8.

van Dijk BA, Boomsma DI, de Man AJ. Blood group chimerism in human multiple births is not rare. Am J Med Genet. 1996;61(3):264-8.
Bianchi DW, Zickwolf GK, Weil GJ, Sylvester S, DeMaria MA. Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum. Proc Natl Acad Sci USA. 1996;93(2):705-8.
Maloney S, Smith A, Furst DE, Myerson D, Rupert K, Evans PC, Nelson JL. Microchimerism of maternal origin persists into adult life. J Clin Invest. 1999;104(1):41-7.
Starzl TE, Demetris AJ, Rao AS, Thomson AW, Trucco M, Murase N, Zeevi A, Fontes P. Spontaneous and iatrogenically augmented leukocyte chimerism in organ transplant recipients. Transplant Proc. 1994;26(5):3071-6.
Johnson KL, Nelson JL, Furst DE, McSweeney PA, Roberts DJ, Zhen DK, Bianchi DW. Fetal cell microchimerism in tissue from multiple sites in women with systemic sclerosis. Arthritis Rheum. 2001;44(8):1848-54.
Cadavid A, Rugeles MT, Peña B, Sánchez F, García H, García G, Botero J, Castañeda, Ossa J. Cell microchimerism in patients with recurrent spontaneous abortion: preliminary results. Early Pregnancy. 1997;3(3):199-203.
Gammill HS, Stephenson MD, Aydelotte TM, Nelson JL. Microchimerism in women with recurrent miscarriage. Chimerism. 2015;16:1-3.
Sarkar K, Miller FW. Possible roles and determinants of microchimerism in autoimmune and other disorders. Autoimmun Rev. 2004;3(6):454-63.
Wou K, Feinberg JL, Wapner RJ, Simpson JL. Cell-free DNA versus intact fetal cells for prenatal genetic diagnostics: what does the future hold? Expert Rev Mol Diagn. 2015;31:1-10.
Zhang L, Wang Y, Liao AH. Quantitative abnormalities of fetal trophoblast cells in maternal circulation in preeclampsia. Prenat Diagn. 2008;28(12):1160-6.
Wataganara T, Bianchi DW. Fetal cell-free nucleic acids in the maternal circulation: new clinical applications. Ann N Y Acad Sci. 2004;1022:90-9.
Malan V, Vekemans M, Turleau C. Chimera and other fertilization errors. Clin Genet. 2006;70(5):363-73.
Lipsker D, Flory E, Wiesel ML, Hanau D, de la Salle H. Between light and dark, the chimera comes out. Arch Dermatol. 2008;144(3):327-30.
Simpson JL, Elias S. Fetal cells in maternal blood. Overview and historical perspective. Ann N Y Acad Sci. 1994;731:1–8.
Firth HV, Boyd PA, Chamberlain P, MacKenzie IZ, Lindenbaum RH, Huson SM.Lancet. Severe limb abnormalities after chorion villus sampling at 56-66 days' gestation.1991;337(8744):762-3.
Karakas B, Qubbaj W, Al-Hassan S, Coskun S. Noninvasive Digital Detection of Fetal DNA in Plasma of 4-Week-Pregnant Women following In Vitro Fertilization and Embryo Transfer. PLoS One. 2015;10(5).
Galbiati S, Brisci A, Damin F, Gentilin B, Curcio C, Restagno G, Cremonesi L, Ferrari M. Fetal DNA in maternal plasma: a noninvasive tool for prenatal diagnosis of beta-thalassemia. Expert Opin Biol Ther. 2012;12 Suppl 1:S181-7.
Vlková B, Turňa J, Celec P. Fetal DNA in maternal plasma in preeclamptic pregnancies. Hypertens Pregnancy. 2015;34(1):36-49.
Neufeld-Kaiser WA, Cheng EY, Liu YJ. Positive predictive value of non-invasive prenatal screening for fetal chromosome disorders using cell-free DNA in maternal serum: independent clinical experience of a tertiary referral center. BMC Med. 2015;13(1):129.
Nelson JL. Naturally acquired microchimerism: for better or for worse. Arthritis Rheum. 2009;60(1):5-7.
Lee Nelson J, Burlingham WJ. The voices of Chimerism. Chimerism. 2010;1(1):1.
Nelson JL, Gillespie KM, Lambert NC, Stevens AM, Loubiere LS, Rutledge JC, et al. Maternal microchimerism in peripheral blood in type 1 diabetes and pancreatic islet beta cell microchimerism. Proc Natl Acad Sci USA. 2007;104(5):1637-42.
Nelson JL. Pregnancy, persistent microchimerism, and autoimmune disease. J Am Med Womens Assoc. 1998;53(1):31-2, 47.
Nelson JL, Furst DE, Maloney S, Gooley T, Evans PC, Smith A, et al. Microchimerism and HLA-compatible relationships of pregnancy in scleroderma. Lancet. 1998;351(9102):559-62.
Bloch EM, Reed WF, Lee TH, Montalvo L, Shiboski S, Custer B, et al. Male microchimerism in peripheral blood leukocytes from women with multiple sclerosis. Chimerism. 2011;2(1):6-10.
Mosca M, Giuliano T, Cuomo G, Doveri M, Tani C, Curcio M, et al. Cell-free DNA in the plasma of patients with systemic sclerosis. Clin Rheumatol. 2009;28(12):1437-40.
Srivatsa B, Srivatsa S, Johnson KL, Samura O, Lee SL, Bianchi DW. Microchimerism of presumed fetal origin in thyroid specimens from women: a case-control study. Lancet. 2001;358(9298):2034-8.
Klintschar M, Immel UD, Kehlen A, Schwaiger P, Mustafa T, Mannweiler S, et al. Fetal microchimerism in Hashimoto's thyroiditis: a quantitative approach. Eur J Endocrinol. 2006;154(2):237-41.
Kremer Hovinga IC, Koopmans M, Baelde HJ, de Heer E, Bruijn JA, Bajema IM. Tissue chimerism in systemic lupus erythematosus is related to injury. Ann Rheum Dis. 2007;66(12):1568-73.
Kremer Hovinga IC, Koopmans M, Grootscholten C, van der Wal AM, Bijl M, Derksen RH, et al. Pregnancy, chimerism and lupus nephritis: a multi-centre study. Lupus. 2008;17(6):541-7.
Stevens AM, Hermes HM, Rutledge JC, Buyon JP, Nelson JL. Myocardial-tissue-specific phenotype of maternal microchimerism in neonatal lupus congenital heart block. Lancet. 2003;362(9396):1617-23.
Guthrie KA, Dugowson CE, Voigt LF, Koepsell TD, Nelson JL. Does pregnancy provide vaccine-like protection against rheumatoid arthritis? Arthritis Rheum. 2010;62(7):1842-8.
Willer CJ, Sadovnick AD, Ebers GC. Microchimerism in autoimmunity and transplantation: potential relevance to multiple sclerosis. J Neuroimmunol 2002;126(1-2):126-33.
Aractingi S, Berkane N, Bertheau P, Le Goué C, Dausset J, Uzan S, et al. Fetal DNA in skin of polymorphic eruptions of pregnancy. Lancet. 1998;352(9144):1898-901.
Hahn S, Holzgreve W. Fetal cells and cell-free fetal DNA in maternal blood: new insights into pre-eclampsia. Hum Reprod Update 2002; 8(6):501-8.
Sarkar K, Miller FW. Possible roles and determinants of microchimerism in autoimmune and other disorders. Autoimmun Rev. 2004;3(6):454-63.
Eren Tİ. Postpartum depresyon: Prevalansı, ve sosyodemografik risk faktörleri (Uzmanlık Tezi). İstanbul, Haydarpaşa Numune Eğitim ve Araştırma Hastanesi, 2007.
Işıkay CT, Özsan H. Şizofrenide viral ve otoimmün etyoloji: Literatürün gözden geçirilmesi. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1998;51:101-6.
Howard Wolinsky. A mythical beast. Increased attention highlights the hidden wonders of chimeras. EMBO Rep. 2007;8(3):212–214.
http://en.wikipedia.org/wiki/Lydia_Fairchild (erişim tarihi:02.05.2015)

Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

-

Yazarlar

İlknur Keskin

Tangül Müdok Bu kişi benim

Yayımlanma Tarihi

31 Aralık 2015

Gönderilme Tarihi

6 Haziran 2015

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2016 Cilt: 2 Sayı: 1

IZ

https://izlik.org/JA34PX28PY

Kaynak Göster

RIS / Bibtex

APA

Keskin, İ., & Müdok, T. (2015). Bir ben var benden içeri; Kimerizm. İbni Sina Tıp Bilimleri Dergisi, 2(1), 1-6. https://izlik.org/JA34PX28PY

AMA

1.Keskin İ, Müdok T. Bir ben var benden içeri; Kimerizm. İbni Sina Tıp Bilimleri Dergisi. 2015;2(1):1-6. https://izlik.org/JA34PX28PY

Chicago

Keskin, İlknur, ve Tangül Müdok. 2015. “Bir ben var benden içeri; Kimerizm”. İbni Sina Tıp Bilimleri Dergisi 2 (1): 1-6. https://izlik.org/JA34PX28PY.

EndNote

Keskin İ, Müdok T (01 Aralık 2015) Bir ben var benden içeri; Kimerizm. İbni Sina Tıp Bilimleri Dergisi 2 1 1–6.

IEEE

[1]İ. Keskin ve T. Müdok, “Bir ben var benden içeri; Kimerizm”, İbni Sina Tıp Bilimleri Dergisi, c. 2, sy 1, ss. 1–6, Ara. 2015, [çevrimiçi]. Erişim adresi: https://izlik.org/JA34PX28PY

ISNAD

Keskin, İlknur - Müdok, Tangül. “Bir ben var benden içeri; Kimerizm”. İbni Sina Tıp Bilimleri Dergisi 2/1 (01 Aralık 2015): 1-6. https://izlik.org/JA34PX28PY.

JAMA

1.Keskin İ, Müdok T. Bir ben var benden içeri; Kimerizm. İbni Sina Tıp Bilimleri Dergisi. 2015;2:1–6.

MLA

Keskin, İlknur, ve Tangül Müdok. “Bir ben var benden içeri; Kimerizm”. İbni Sina Tıp Bilimleri Dergisi, c. 2, sy 1, Aralık 2015, ss. 1-6, https://izlik.org/JA34PX28PY.

Vancouver

1.İlknur Keskin, Tangül Müdok. Bir ben var benden içeri; Kimerizm. İbni Sina Tıp Bilimleri Dergisi [Internet]. 01 Aralık 2015;2(1):1-6. Erişim adresi: https://izlik.org/JA34PX28PY