Endojen Adenozin’in Santral Solunum Kontrol Mekanizmalarına Etkisi

Yıl 2006, Cilt: 37 Sayı: 3, 92 - 97, 19.07.2014

İbrahim Güner Tülin Oruç Gülderen Şahin Rıfat Yücel Nermin Yelmen

Anahtar Kelimeler

Hipoksi , ICV dipyridamole , endojen adenozin

Kaynakça

• 1. Vizek M, Pickett CK, Weil JV. Biphasic ventilatory response of adult cats to sustained hypoxia has central origin. J Appl Physiol 1987; 63: 1658-1664.
• 2. fiahin G, Terzio¤lu M. The influence of chronic hypoxia on erytrocytic 2.3 diphospho glycerate and the sensivity of peripheral chemoreceptors of rabbits. Cerrahpafla Med Rev 1985; 4: 46-56.
• 3. Maxova M, Vizek M. Biphasic ventilatory response to hypoxia in unanesthetized rats. Physiol Res 2001; 50: 91-96.
• 4. Maxova H, Vizek M. Ventilatory response to sustained hypoxia in carotid body denervated rats. Physiol Res 2001; 50: 327-331.
• 5. Long WO, Ggiestbrecht GG,Anthonisen NR. Ventilatory response to moderate hypoxia in awake chemodenervated cats. J Appl Physiol 1993; 74: 805-810.
• 6. Richter DW, Schmit-Garcon P, Pierrefishe O, and et al. Neurotransmitters and neuromodulators controlling the hypoxic respiratory response in anesthetized cat. J Physiol 1999; 514: 567-578. .
• 7. Winn HR, Rubio R, Berne RM. Brain adenosine concentrationduring hypoxia in rats. Am J Physiol 1981; 241: 235-242.
• 8. Gourine AV, Llaudet E, Thomas T, and et al. Adenosine release in nucleus tractus solitarii does not appear to mediate hypoxia induced respiratory depression in rats. J Physiol 2002; 544: 161-170.
• 9. Wu JD. A possible role for gamma amino butyric acid in the homeostatic control of brain metabolism under conditions of hypoxia. Exp Brain Res 1967; 4: 81-84.
• 10. Melton JE, Neubauer JA, Edelman NH. Gaba antagonism reverses hypoxic respiratory depression in the cat. J Appl Physiol 1990; 69: 1296-1301. .
• 11. Yelmen NK. Anestezi verilmifl tavflanlara intraserebroventriküler GABA verilmesinin hipoksik solunum cevab›na etkisi. Solunum 2003; 5: 73-80. .
• 12. Tatsumi K, Pickett CK, Weil JW. Effect of haloperidol and domperidone on ventilatory roll off during sustained hypoxia in cats. J Appl Physiol 1992; 72: 1945-1952.
• 13. Güner ‹, Yelmen N, fiahin G, ve ark. The effect of intracerebroventricular dopamine administration on the respiratory response to hypoxia. Tohoku J Exp Med 2002; 196: 219-230.
• 14. Wenging L, Lobchuk D, Anthonishen NR. Ventilatory response to CO2 and hypoxia after sustained hypoxia in awake cats. J Appl Physiol 1994; 76: 2262-2266.
• 15. Krnjevic K. Early effects of hypoxia on brain cell function. Croat Med J 1999; 40: 375-380. .
• 16. Elridge FL, Milhorn DE, Waldrop TG, and et al. Mechanism of respiratory effects of methylxanthines. Respir Physiol 1983; 53: 239-261.
• 17. Phillis JW, Kostopoulus GK, Limacher JJ. Depression of cortico-spinal cells by various purines and pyrimidines. Can J Physiol Pharmacol 1974; 52: 1226- 1229.
• 18. Elridge FL, Milhor DE, Kiley JP. Respiratory effect of a long-acting analog of adenosine. Brain Res 1984; 301: 273-280.
• 19. Cunha RA. Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: different roles, different sources and different receptors (Review). Neurochem Int 2001; 38: 107-125. .
• 20. Engelstein ED, Lerman BB, Somers VK, and et al. Role of arterial chemoreceptors in mediating the effects of endogenous adenosine on sympathetic nerve activity. Circulation 1994; 90: 2919-2926.
• 21. Oruç T, Terzio¤lu M, fiahin G, ve ark. Response of the central respiratory control mechanism to hyperoxia and hypoxia. Bull Europ Physiopath Resp 1982; 18: 439-447.
• 22. Oruc T. The activation of the central and peripheral respiratory control mechanism in hyperoxia and hypoxia. Bull Europ Physiopath Resp Suppl 1982; 18: 113.
• 23. Terzio¤lu M, Yi¤it G, Oruç T. Fizyoloji ders kitab›. Cilt II (Geniflletilmifl 2. bask›), ‹stanbul Üniversitesi Cerrahpafla T›p Fakültesi Yay›nlar›. ‹stanbul, 1993.
• 24. Klabunde RE. Dipyridamole inhibition of adenosine metabolism in human blood. Eur J Pharmacol 1983; 93: 21-26.
• 25. Sollevi A, Stergren J, Fagrell B, and et al. Teophylline antagonizes cardio-vascular responses to dipyridamole in man without affecting increases in plasma adenosine. Acta Physiol Scand 1984; 121: 165-171.
• 26. Runold M, Lagercrantz H, Fredholm BB. Ventilatory effect of an adenosine analogue in unanesthetized rabbits during devolopment. J Apll Physiol 1986; 61: 255-259.
• 27. Brundege JM, Dunwiddio TV. Role of adenosine as a modulator of synaptic activity in the central nervous system. Advances in Pharmacol 1997; 39: 353-391.
• 28. Herlenius E, Lagercrantz H. Adenosinergic modulation of the respiratory neurons in the neonatal rat brainstem in vitro. J Physiol 1999; 518: 159-172.
• 29. Kang MJ, Park MS, Shin IC, and et al. Modification of cardiovascular response of posterior hipotalamic adenosine A2 receptor stimulation by adenylate cyclase, guanilate cyclase and by K(ATP) channel blockade in anesthetized rats. Neurosci Lett 2003; 344: 57-61.
• 30. Lee HH, Koh HC, Chae SL, and et al. Modification of cardiovascular responses to adenosine A1 receptor stimulation in the posterior hypothalamus of anaesthetized ratss by cAMP and by GABA (B) receptor blockade. J Auton Pharmacol 2001; 21: 249-254.
• 31. Lo WC, Jan CR, Wu SN, and et al. Cardiovascular effectsof nitric oxide and adenosine in the nucleus tractus solitarii of rats. Hypertension 1998; 32: 1034- 1038.
• 32. Beckenbosh A, De Gioede J. Effects of brain hypoxia on ventilation Eur Respir J 1988; 1: 184-190. .
• 33. Herlenius E, Lagercrantz H, Yamamoto Y. Adenosine modulates inspiratory neurons and the respiratory pattern in the brainstem of neonatal rats. Pediatric Researc 1997; 42: 46-53.