Öz
Background.- c-fos is a gene that is transcribed temporarily and rapidly by factors that cause growth and differentiation by affecting cells. Fos proteins are nuclear proteins that are produced by c-fos gene. c-fos is considered to be a third nuclear messenger. The expression and accumulation of c-fos gene, a protooncogen that is a member of IEG (Immediate Early Gene) group, and Fos proteins, a member of AP-1 (Activator Protein-1) family oncoproteins, upsurge along with cellular activation under the affect of certain stimuli. This gene and proteins play a very important role during cellular proliferation, differentiation and programmed cell death (apoptosis). The c-fos gene and Fos proteins, being a potential activator of transcription, are a key to understand congenital anomalies, oncogenic transformation and normal development due to their relationship with abovementioned biological processes.
* Anahtar Kelimeler: c-fos, Fos proteinleri, hücre çoğalması, farklılaşma
* Key Words: c-fos, Fos proteins, cellular proliferation, differentiation
Anahtar Kelimeler
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Olgu Sunumları |
| Yazarlar | |
| Yayımlanma Tarihi | 27 Temmuz 2014 |
| Yayımlandığı Sayı | Yıl 2004 Cilt: 35 Sayı: 1 |