BibTex RIS Kaynak Göster

ELEKTRİKLE UYARILAN İZOLE KOBAY VE FARE SOL ATRİYUMU VE SIÇAN DİYAFRAMININ KASILMASI ÜZERİNE KALSİTONİN'İN ETKİLERİ*

Yıl 2000, Cilt: 31 Sayı: 3, 0 - , 20.08.2014

Öz

Background.- Although the regulatory role of calcitonin released from the parafolicular cells of thyroid gland and plays essential role in the haemoestasis of blood Ca2+ was well documented, its effects on the physiological functions of tissues except bones is not as yet fully established. Therefore, the aim of this study was to explore, how calcitonin act on the contractile activity of heart and striated muscle.

Design and Results.- Experiments were carried out on the isolated electrically driven left atria of guinea-pigs and mice and phrenic nerve-diaphragm preparations of rats. In the electrically driven guinea-pig left atria (1 Hz, 2 msec, 2x threshold voltage), contractility was depressed by ampule calcitonin (miacalcic) in a dose-dependent manner at concentrations in range of 0.25-4 mg/ml. This effect of ampule calcitonin was weaker with respect to those produced by the solvent being in the same size. Especially at 2 and 4mg/ml of ampule calcitonin, the contractile response was biphasic, e.g. an initial short-lived positive inotropic effect was preceding the main negative inotropic one. Theophylline (0.5 mM), atropine (2 mg/ml) and methylene blue (2 mg/ml) antagonized ampule calcitonin nonsignificantly, whereas the effect of solvent remained unaltered. Verapamil (0.5 mg/ml), however, augmented the negative inotropic effect of both ampule calcitonin and the solvent. In the phrenic nerve-diaphragm preparation, although contractions induced by direct electrical stimulation (0.1 Hz, 5 msec, 2x threshold voltage) was depressed by ampule calcitonin dose-dependently in a concentration range of 1-8 mg/ml, contractions induced by nerve stimulation (0.1 Hz, 1 msec, 2x threshold voltage) was augmented over a concentration of 4 mg/ml.

Conclusion.- Depending on these findings, it was concluded that calcitonin has a stimulatory effect on the contractile function of heart and striated muscle which is masked by the solvent and that cAMP, cGMP and Ca2+ channels all appeared to involve in the cardiac effects of the test agent.

Aşkın Ç, Barlas A, Küçükhüseyin C. Effects of calcitonin on the contractility of isolated electrically driven guinea-pig and mouse left atria and rat diaphragm. Cerrahpaşa J Med 2000; 31 (3): 155-162.


* Anahtar Kelimeler: 
Kalsitonin, Miyokard, Çizgili kas, cAMP, cGMP

* Key Words: Calcitonin, Myocard, Striated Muscle, cAMP, cGMP

Yıl 2000, Cilt: 31 Sayı: 3, 0 - , 20.08.2014

Öz

Toplam 0 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Araştırmalar
Yazarlar

Çiğdem Aşkın Bu kişi benim

Aydın Barlas Bu kişi benim

Cihat Küçükhüseyin Bu kişi benim

Yayımlanma Tarihi 20 Ağustos 2014
Yayımlandığı Sayı Yıl 2000 Cilt: 31 Sayı: 3

Kaynak Göster

APA Aşkın, Ç., Barlas, A., & Küçükhüseyin, C. (2014). ELEKTRİKLE UYARILAN İZOLE KOBAY VE FARE SOL ATRİYUMU VE SIÇAN DİYAFRAMININ KASILMASI ÜZERİNE KALSİTONİN’İN ETKİLERİ*. Cerrahpaşa Tıp Dergisi, 31(3).
AMA Aşkın Ç, Barlas A, Küçükhüseyin C. ELEKTRİKLE UYARILAN İZOLE KOBAY VE FARE SOL ATRİYUMU VE SIÇAN DİYAFRAMININ KASILMASI ÜZERİNE KALSİTONİN’İN ETKİLERİ*. Cerrahpaşa Tıp Dergisi. Eylül 2014;31(3).
Chicago Aşkın, Çiğdem, Aydın Barlas, ve Cihat Küçükhüseyin. “ELEKTRİKLE UYARILAN İZOLE KOBAY VE FARE SOL ATRİYUMU VE SIÇAN DİYAFRAMININ KASILMASI ÜZERİNE KALSİTONİN’İN ETKİLERİ*”. Cerrahpaşa Tıp Dergisi 31, sy. 3 (Eylül 2014).
EndNote Aşkın Ç, Barlas A, Küçükhüseyin C (01 Eylül 2014) ELEKTRİKLE UYARILAN İZOLE KOBAY VE FARE SOL ATRİYUMU VE SIÇAN DİYAFRAMININ KASILMASI ÜZERİNE KALSİTONİN’İN ETKİLERİ*. Cerrahpaşa Tıp Dergisi 31 3
IEEE Ç. Aşkın, A. Barlas, ve C. Küçükhüseyin, “ELEKTRİKLE UYARILAN İZOLE KOBAY VE FARE SOL ATRİYUMU VE SIÇAN DİYAFRAMININ KASILMASI ÜZERİNE KALSİTONİN’İN ETKİLERİ*”, Cerrahpaşa Tıp Dergisi, c. 31, sy. 3, 2014.
ISNAD Aşkın, Çiğdem vd. “ELEKTRİKLE UYARILAN İZOLE KOBAY VE FARE SOL ATRİYUMU VE SIÇAN DİYAFRAMININ KASILMASI ÜZERİNE KALSİTONİN’İN ETKİLERİ*”. Cerrahpaşa Tıp Dergisi 31/3 (Eylül 2014).
JAMA Aşkın Ç, Barlas A, Küçükhüseyin C. ELEKTRİKLE UYARILAN İZOLE KOBAY VE FARE SOL ATRİYUMU VE SIÇAN DİYAFRAMININ KASILMASI ÜZERİNE KALSİTONİN’İN ETKİLERİ*. Cerrahpaşa Tıp Dergisi. 2014;31.
MLA Aşkın, Çiğdem vd. “ELEKTRİKLE UYARILAN İZOLE KOBAY VE FARE SOL ATRİYUMU VE SIÇAN DİYAFRAMININ KASILMASI ÜZERİNE KALSİTONİN’İN ETKİLERİ*”. Cerrahpaşa Tıp Dergisi, c. 31, sy. 3, 2014.
Vancouver Aşkın Ç, Barlas A, Küçükhüseyin C. ELEKTRİKLE UYARILAN İZOLE KOBAY VE FARE SOL ATRİYUMU VE SIÇAN DİYAFRAMININ KASILMASI ÜZERİNE KALSİTONİN’İN ETKİLERİ*. Cerrahpaşa Tıp Dergisi. 2014;31(3).