Okült Hepatit B Virus Enfeksiyonu: Virolojik ve Moleküler Mekanizmalar

Yıl 2016, Cilt: 6 Sayı: 11, 22 - 42, 01.06.2016

Bülent Çakal

Öz

Okült
Hepatitis B Virus (HBV) enfeksiyonu (Occult HBV infection; OBİ) serum HBV DNA
statüsü dikkate alınmaksızın mevcut serolojik testler ile HBV yüzey antijeni
(HBsAg) negatif tespit edilen bireylerin karaciğerinde HBV genomunun uzun
süreli persistan varlığı olarak tanımlanır. OBİ’nin Hepatoselüler karsinoma (HSK) riski ile kronik
karaciğer hastalığının (KKH) progresyonunun artışına sebep olabilen önemli bir
risk faktörü olduğu hipotez edilmektedir. OBİ virüse ve infekte
konağa ait faktörler ile çevresel faktörlerin zemininde gelişen genetik, epigenetik
ve immünolojik mekanizmaların karşılıklı etkileşimi ile şekillenen, kronik HBV
enfeksiyonunun doğal seyri içerisinde muhtemelen safhalarından biri olarak
değerlendirilmesine karşın, HBV enfeksiyonunun bu özgün formuna neden olan
mekanizmalar henüz tam olarak belirlenememiştir. Bu derlemede OBİ’nin virolojik
özellikleri ve moleküler mekanizmalarının aydınlatılmasına yönelik bilimsel
literatürün irdelenmesi amaçlanmıştır. 

Anahtar Kelimeler

okült hepatitis b, viroloji, enfeksyon

Kaynakça

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