DİYABET HASTALIĞINDA OSTEOPROTEGERİN (OPG) PROTEİNİ T950C GEN POLİMORFİZMİNİN İNCELENMESİ

Yıl 2011, Cilt: 1 Sayı: 1, 40 - 46, 25.10.2011

Burak Esen Selçuk Daşdemir Zeynep Çinçin Abdullah Özdemircan Bedia Çakmakoğlu

Öz

Osteoprotegerin (OPG), TN F (tümör nekroz faktör) bağımlı ailenin bir üyesi ve NF-KB
ligandının (RANKL) reseptör aktivatörü ve NF-KB (RANK) reseptör aktivatörüdür. OPG
polimorfizmlerinin diyabet hastalığında risk arttırıcı faktörler olduğu, çeşitli çalışmalarla
gösterilmiştir. Biz çalışmamızda, PZR, RFLP ve agaroz jel elektroforezi yöntemlerini
kullanarak 77 tip II diyabet hastası ve 83 sağlıklı kontrol üzerinde OPG T950C gen
polimorfîzmini araştırdık.
OPG T950C genotip dağılımları; hasta grubunda %41,56 TT, %15,58 CC, %42,86 TC olarak
bulunurken, kontrol grubunda ise %31,62 TT, % 14,70 CC, %53,68 TC olarak saptanmıştır.
Hasta ve kontrol grupları arasında OPG T950C genotip ve allel frekansları açısından
istatistiksel anlamlı bir fark gözlemlenmemiştir (p > 0.05). Bununla birlikte, hasta grubunda
OPG T950C CC genotipi frekansının myokard infarktüsü (MI) varlığında 3,15 kat, sol
ventrikül hipertrofisi (LVH) varlığında 1,38 kat, aile hikayesinde DM (+) bireylerde 4 kat,
erkeklerde 2,6 kat, hipertansiflerde 2,33 kat, aile hikayesinde koroner arter hastalığı (KAH)
(+) hastalarda 2,3 kat arttığını gözlemlenmiştir. KAH gehşiminde etkili faktörlerin varlığında
CC genotipinin frekansındaki artış bu genotipin bir risk faktörü olabileceğini düşündürmektedir.
Sonuç olarak, çalışmamızda OPG T950C polimorfizminin diyabet hastalarında KAH
gelişiminde etkili olabileceği belirlenmiştir.

Kaynakça

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