ESTIMATION OF OXYGEN SATURATION WITH LASER OPTICAL IMAGING METHOD

Öz

The aim of this study is to determine the estimation of hemoglobin concentration and oxygen saturation of tissue by non-invasively functional laser imaging for early skin cancer diagnosis. The early diagnosis of melanoma is a key factor that remarkably reduces the mortality rate. Diffuse reflectance spectroscopy is a very useful device for diagnosis and treatment purposes under in-vivo conditions. At this point, the aforementioned device, which takes into account the scattering of tissue, is to determine the concentration of chromophores (or optical absorbers) due to attenuated light strikes to the superficial layer of tissue. Laser-type light based imaging techniques in medical diagnosis substantially produce good results. Consequently, the aim of this study is to estimate HbO₂ (%) and Hb (%) concentrations by use of a single wavelength (680 nm).

Anahtar Kelimeler

• Melanoma,oxygen saturation,laser,non-invasive imaging,hemoglobin

Kaynakça

1. Faber D. J. et al. “Oxygen saturation-dependent absorption and scattering of blood”, Physical Review Letters 93, 028102, 2004.
2. van Assendelft O.W., “Spectrophotometry of Hemoglobin Derivatives”, Royal Vangorcum Assen, Springfield, 1970.
3. Zijlstra W.G., Buursma A., and Meeuwsen-van der Roest W. P., Clin. Chem. 37, 1633, 1991
4. Wray S. et al., Biochim. Biophys. Acta 933, 184, 1988
5. Tabulated data from various sources compiled by S. Prahl, 30/08/2016, Avaible: http://omlc.ogi.edu/spectra,
6. Gao F., Peng Q. W., Feng X. H., Gao B., and Zheng Y. J., “Single-Wavelength Blood Oxygen Saturation Sensing With Combined Optical Absorption and Scattering”, IEEE Sensors Journal, vol. 16, no. 7, pp. 1943-1948, Apr 1, 2016
7. Kiekkas P. et al., “Knowledge of pulse oximetry: Comparison among intensive care, anesthesiology and emergency nurses”, J. Clin. Nursing, vol. 22, nos. 5–6, pp. 828–837, Mar. 2013
8. Humphreys K., Ward T., and Markham C., “Noncontact simultaneous dual wavelength photoplethysmography: A further step toward noncontact pulse oximetry”, Rev. Sci. Instrum., vol. 78, no. 4, p. 044304, Apr. 2007

9. Millikan G. A., “The oximeter, an instrument for measuring continuously the oxygen saturation of arterial blood in man”, Rev. Sci. Instrum., vol. 13, no. 10, pp. 434–444, Oct. 1942
10. Hernández S. E., Rodríguez V. D., Pérez J., Martín F. A., Castellano M. A., and Gonzalez-Mora J. L., “Diffuse reflectance spectroscopy characterization of hemoglobin and intralipid solutions: in vitro measurements with continuous variation of absorption and scattering”, J. Biomed. Opt.14 (3), 034026, 2009
11. Memorandum of Understanding for the implementation of a European Concerted Research Action designated as COST Action BM1205: European Network for Skin Cancer Detection using Laser Imaging, 2012
12. Dhawan A. P., D'Alessandro B., “Multispectral Transillumination Imaging of Skin Lesions for Oxygenated and Deoxygenated Hemoglobin Measurement”, New Jersey Institute of Technology, Newark, NJ, 2010