In this paper, we investigate dynamics of voltage-gated ionic channels which are of great importance in integrating the information received by neurons. Understanding of dynamical behavior of voltage-gated ionic channels plays a major role for determining underlying mechanism of spike activity and predicting the neuronal behavior. Investigation is carried out based on Hodgkin-Huxley (H-H) mathematical formalism. Ionic channel gate model is discussed briefly. Relaxation phenomenon is studied in the gate variables. Then effects of temperature on dynamics of gate variables are examined. Finally voltage-clamped simulations are carried out to determine their dynamic behaviors based on squid giant axon.
Birincil Dil | İngilizce |
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Bölüm | Makaleler |
Yazarlar | |
Yayımlanma Tarihi | 28 Aralık 2011 |
Yayımlandığı Sayı | Yıl 2004 Cilt: 4 Sayı: 1 |