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Yıl 2020, Cilt: 50 Sayı: 1, 33 - 41, 01.04.2020

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Kaynakça

  • • Abu-Darwish, M., Cabral, C., Goncalves, M., Cavaleiro, C., Cruz, M., Paoli, M., & Salgueiro, L. (2016). Ziziphora tenuior L. essential oil from Dana Biosphere Reserve (Southern Jordan); Chemical characterization and assessment of biological activities. Journal of Ethnopharmacology, 194, 963–970.
  • • Ali-Shtayeh, M. S., Jamous, R. M., Al-Shafie, J. H., Elgharabah, W. A., Kherfan, F. A., Qarariah, K. H., & Isa, B. A. (2008). Traditional knowledge of wild edible plants used in Palestine (Northern West Bank): a comparative study. Journal of Ethnobiology and Ethnomedicine, 4(1), 1–13.
  • • Alp, S., Ercisli, S., Dogan, H., Temim, E., Leto, A., Zia-Ul-Haq, M., & Aladag, H. (2016). Chemical composition and antioxidant activity Ziziphora clinopodioides ecotypes from Turkey. Romanian Biotechnological Letters, 21(2), 11298–11303.
  • • Apak, R., Güçlü, K., Özyürek, M., & Karademir, S. E. (2004). Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method. Journal of Agricultural and Food Chemistry, 52(26), 7970–7981.
  • • Blois, M. S. J. N. (1958). Antioxidant determinations by the use of a stable free radical. Nature, 181(4617), 1199–1200.
  • • Boga, M., Ertas, A., Eroglu-Ozkan, E., Kizil, M., Ceken, B., & Topcu, G. (2016). Phytochemical analysis, antioxidant, antimicrobial, anticholinesterase and DNA protective effects of Hypericum capitatum var. Capitatum extracts. South African Journal of Botany, 104, 249–257.
  • • Celik, C., Tutar, U., Karaman, I., Hepokur, C., & Atas, M. (2016). Evaluation of the antibiofilm and antimicrobial properties of Ziziphora tenuior L. essential oil against multidrug-resistant Acinetobacter baumannii. Inernational Journal of Pharmacology, 12, 28–23.
  • • Cho, N., Ransom, T. T., Sigmund, J., Tran, T., Cichewicz, R. H., Goetz, M., & Beutler, J. A. (2017). Growth inhibition of colon cancer and melanoma cells by versiol derivatives from a paraconiothyrium species. Journal of Natural Products, 80(7), 2037–2044.
  • • Clinical and Laboratory Standards Institute. (1997). Reference method for broth dilution antifungal susceptibility testing of yeasts; Approved standard–Second Edition; M27-A2. Wayne, PA: Author.
  • • Clinical and Laboratory Standards Institute. (2006). Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 7th ed.; Approved standard M7-A7. Wayne, PA: Author.
  • • Clinical and Laboratory Standards Institute. (2010). Performance standards for antimicrobial susceptibility testing: 7th informational supplement; M100-S20. Wayne, PA: Author.
  • • Ellman, G. L., Courtney, K. D., Andres Jr, V., & Featherstone, R. M. (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology, 7(2), 88–95.
  • • Ghanbarian, G., Jafari, E., & Bahmanzadegan, A. (2017). Essential oil composition of aerial parts of Ziziphora clinopodioides Lam. from Western of Shiraz, Iran. Analytical Chemistry Letters, 7(3), 383–388.
  • • Gursoy, N., Sihoglu-Tepe, A., & Tepe, B. (2009). Determination of in vitro antioxidative and antimicrobial properties and total phenolic contents of Ziziphora clinopodioides, Cyclotrichium niveum, and Mentha longifolia ssp. typhoides var. typhoides. Journal of Medicinal Food, 12(3), 684–689.
  • • Hamedi, H., Kargozari, M., Shotorbani, P. M., Mogadam, N. B., & Fahimdanesh, M. (2017). A novel bioactive edible coating based on sodium alginate and galbanum gum incorporated with essential oil of Ziziphora persica: The antioxidant and antimicrobial activity, and application in food model. Food Hydrocolloids, 72, 35–46.
  • • Hearing, V. J., & Jiménez, M. (1987). Mammalian tyrosinase-the critical regulatory control point in melanocyte pigmentation. International Journal of Biochemistry, 19(12), 1141–1147.
  • • Heinrich, M., & Gibbons, S. (2001). Ethnopharmacology in drug discovery: An analysis of its role and potential contribution. Journal of Pharmacy and Pharmacology, 53(4), 425-432.
  • • Kaya, A., & Dirmenci, T. (2012). Nutlet morphology of Turkish Ziziphora L. (Lamiaceae). Plant Biosystems-An International Journal Dealing with all Aspects of Plant Biology, 146(3), 560–563.
  • • Kheirkhah, M., Ghasemi, V., Yazdi, A. K., & Rahban, S. (2015). Chemical composition and insecticidal activity of essential oil from Ziziphora clinopodioides Lam. used against the Mediterranean flour moth, Ephestia kuehniella Zeller. Journal of Plant Protection Research, 55(3), 260–265.
  • • Khodaverdi-Samani, H., Pirbalouti, A. G., Shirmardi, H.-A., & Malekpoor, F. (2015). Chemical composition of essential oils of Ziziphora clinopodioides Lam.(endemic Iranian herb) collected from different natural habitats. Indian Journal of Traditional Knowledge, 1(1), 57–62.
  • • Ma, B.-X., Ban, X.-Q., He, J.-S., Huang, B., Zeng, H., Tian, J. & Wang, Y.-W. (2016). Antifungal activity of Ziziphora clinopodioides Lam. essential oil against Sclerotinia sclerotiorum on rapeseed plants (Brassica campestris L.). Crop Protection, 89, 289–295.
  • • Mahboubi, A., Kamalinejad, M., Ayatollahi, A. M., & Babaeian, M. (2014). Total phenolic content and antibacterial activity of five plants of Labiatae against four foodborne and some other bacteria. Iranian Journal of Pharmaceutical Research, 13(2), 559–566.
  • • Maral, H., Taghikhani, H., Kaya, A., & Kırıcı, S. (2015). The effect of different levels of altitutes on composition and content of essential oils of Ziziphora clinopodioides in southern Turkey. International Journal of Agriculture and Wildlife Science, 1(1), 1–6.
  • • Miller, H. (1971). A simplified method for the evaluation of antioxidants. Journal of the American Oil Chemists Society, 48(2), 91.
  • • Mohammadhosseini, M., Akbarzadeh, A., Hashemi-Moghaddam, H., Shahnama, M., Fahimi, B., & Azami, S. (2016). Gas chromatographic-mass spectrometric analysis of volatiles obtained by HSSPME-GC-MS technique from aerial parts of Ziziphora capitata L., and evaluation for biological activity. Oriental Journal of Chemistry, 32(3), 1439–1451.
  • • Moreno, M. a. I. N., Isla, M. a. I., Sampietro, A. R., & Vattuone, M. A. (2000). Comparison of the free radical-scavenging activity of propolis from several regions of Argentina. Journal of Ethnopharmacology, 71(1–2), 109–114.
  • • Nickavar, B., & Tavakoli, F. (2016). Comparative analysis of volatile constituents from two Ziziphora clinopodioides subspecies (Z. clinopodioides subsp. elbursensis and Z. clinopodioides subsp. filicaulis). Journal of Essential Oil Bearing Plants, 19(8), 2072–2076.
  • • Okut, N., Selcuk, N., Yagmur, M., & Yildirim, B. (2018). Chemical diversity of essential oil from leaves of Ziziphora clinopodioides growing in Van, Turkey. Fresenius Environmental Bulletin, 2785–2790.
  • • Ozdemir, A., Turkoglu, V., & Demir, H. (2013). In vitro effect of some plant extracts on acetylcholinesterase enzyme in human erythrocytes and serum. Fresenius Environmental Bulletin, 22(9), 2510–2515.
  • • Ozturk, S., & Ercisli, S. (2007). Antibacterial activity and chemical constitutions of Ziziphora clinopodioides. Food Control, 18(5), 535–540.
  • • Pakdel, F., Ghasemi, S., Babaloo, A., Javadzadeh, Y., Momeni, R., Ghanizadeh, M. & Fathi, F. Y. (2017). Antibacterial effects of garlic • extracts and Ziziphora essential oil on bacteria associated with • peri-Implantitis. Journal of Clinical and Diagnostic Research, 11(4), ZC16–ZC19.
  • • Re, R., Pellegrini, N., Proteggente, A., Pannala, A., Yang, M., RiceEvans, C. J. F. r. b., & medicine. (1999). Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biology and Medicine, 26(9–10), 1231–1237.
  • • Salehi, P., Sonboli, A., Eftekhar, F., Nejad-Ebrahimi, S., & Yousefzadi, M. (2005). Essential oil composition, antibacterial and antioxidant activity of the oil and various extracts of Ziziphora clinopodioides subsp. rigida (BOISS.) RECH. f. from Iran. Biological and Pharmaceutical Bulletin, 28(10), 1892-1896.
  • • Selvi, S., Satil, F., Martin, E., Celenk, S., & Dirmenci, T. (2015). Some evidence for infrageneric classification in Ziziphora L. (Lamiaceae: Mentheae). Plant Biosystems-An International Journal Dealing with all Aspects of Plant Biology, 149(2), 415–423.
  • • Shahbazi, Y. (2015). Chemical composition and in vitro antibacterial effect of Ziziphora clinopodioides essential oil. Pharmaceutical Sciences, 21(2), 51–56.
  • • Shahbazi, Y., Shavisi, N., & Mohebi, E. (2017). Antibacterial activity of Ziziphora clinopodioides essential oil and nisin against Bacillus subtilis and Salmonella typhimurium in commercial barley soup. Bulgarian Journal of Veterinary Medicine, 20(1), 65–72.
  • • Tian, S., Shi, Y., Zhou, X., Ge, L., & Upur, H. (2011). Total polyphenolic (flavonoids) content and antioxidant capacity of different Ziziphora clinopodioides Lam. extracts. Pharmacognosy Magazine, 7(25), 65–68.
  • • Unal, E. L., Mavi, A., Kara, A. A., Cakir, A., Şengül, M., & Yildirim, A. (2008). Antimicrobial and antioxidant activities of some plants used as remedies in Turkish traditional medicine. Pharmaceutical Biology, 46(3), 207–224.
  • • Yilmaz, M. A., Ertas, A., Yener, I., Akdeniz, M., Cakir, O., Altun, M., Demirtas, I., Boga, M., & Temel, H. (2018). A comprehensive LC– MS/MS method validation for the quantitative investigation of 37 fingerprint phytochemicals in Achillea species: A detailed examination of A. coarctata and A. monocephala. Journal of Pharmaceutical and Biomedical Analysis, 154, 413–424.
  • • Zahid, H., Rizwani, G. H., Kamil, A., Shareef, H., Tasleem, S., & Khan, A. (2015). Anti-urease activity of Mimusops elengi Linn (Sapotaceae). European Journal of Medicinal Plants, 6(4), 223–230.
  • • Zhang, X.-M., An, D.-Q., Guo, L.-L., Yang, N.-H., & Zhang, H. (2019). Identification and screening of active components from Ziziphora clinopodioides Lam. in regulating autophagy. Natural Product Research, 33(17), 2549–2553.

LC-MS/MS analyses of Ziziphora clinopodioides Lam. from Turkey: Antioxidant, anticholinesterase, antimicrobial and, anticancer activities

Yıl 2020, Cilt: 50 Sayı: 1, 33 - 41, 01.04.2020

Öz

Background and Aims: Ziziphora clinopodioides is one of the wild edible species used in Turkish folk medicine. The study was aimed to investigate the phenolic compounds of the extracts as well as the antioxidant, enzyme inhibitory, antimicrobial activities, and anticancer potential. Methods: LC-MS/MS was used to determine phenolic compounds; antioxidant potential was evaluated by using radical scavenging assays; enzyme inhibition assays were used for anticholinesterase, tyrosinase, and urease activities; antimicrobial activities were performed by microdilution method; and XTT bioassay was used for testing anticancer potential. Results: The LC-MS/MS results indicate that quinic acid (9020.51±73.97 µg/g; 14721.04±120.71 µg/g, respectively) is the major compound, malic acid (1972.95±22.29 µg/g; 2179.04±24.62 µg/g, respectively) and rhoifolin (1044.74±98.31 µg/g; 3593.31±338.13µg/g, respectively) are the abundant compounds in aerial and root extracts. The antioxidant activity results showed that the aerial parts extract has stronger ABTS cation radical and DPPH free radical scavenging activity than the root extract with 40.90±0.19 µg/mL, and 94.27±0.64 µg/mL IC50 values, respectively. The extracts showed moderate cupric reducing activity with 1.74 absorbance value at 100 µg/mL. Only the aerial parts extract exhibited weak tyrosinase inhibition (8.60±0.87%) compared with kojic acid (95.26±0.23%) at 200 µg/mL. No activity was observed in urease and anticholinesterase enzymes. Both extracts exhibited moderate antifungal activity against Candida tropicalis with 39.06 µg/mL MIC values. The extracts didn’t show cytotoxic activity against Renal (A498, UO-31) and Colo (COLO205, KM12) cell lines, also there is no metastatic potential of the extracts against osteosarcoma cell lines (MG63.3, MG63). Conclusion: Z. clinopodioides has rich phytochemical constituents with powerful health benefits, and doesn’t have any harmful effect on the body.

Kaynakça

  • • Abu-Darwish, M., Cabral, C., Goncalves, M., Cavaleiro, C., Cruz, M., Paoli, M., & Salgueiro, L. (2016). Ziziphora tenuior L. essential oil from Dana Biosphere Reserve (Southern Jordan); Chemical characterization and assessment of biological activities. Journal of Ethnopharmacology, 194, 963–970.
  • • Ali-Shtayeh, M. S., Jamous, R. M., Al-Shafie, J. H., Elgharabah, W. A., Kherfan, F. A., Qarariah, K. H., & Isa, B. A. (2008). Traditional knowledge of wild edible plants used in Palestine (Northern West Bank): a comparative study. Journal of Ethnobiology and Ethnomedicine, 4(1), 1–13.
  • • Alp, S., Ercisli, S., Dogan, H., Temim, E., Leto, A., Zia-Ul-Haq, M., & Aladag, H. (2016). Chemical composition and antioxidant activity Ziziphora clinopodioides ecotypes from Turkey. Romanian Biotechnological Letters, 21(2), 11298–11303.
  • • Apak, R., Güçlü, K., Özyürek, M., & Karademir, S. E. (2004). Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method. Journal of Agricultural and Food Chemistry, 52(26), 7970–7981.
  • • Blois, M. S. J. N. (1958). Antioxidant determinations by the use of a stable free radical. Nature, 181(4617), 1199–1200.
  • • Boga, M., Ertas, A., Eroglu-Ozkan, E., Kizil, M., Ceken, B., & Topcu, G. (2016). Phytochemical analysis, antioxidant, antimicrobial, anticholinesterase and DNA protective effects of Hypericum capitatum var. Capitatum extracts. South African Journal of Botany, 104, 249–257.
  • • Celik, C., Tutar, U., Karaman, I., Hepokur, C., & Atas, M. (2016). Evaluation of the antibiofilm and antimicrobial properties of Ziziphora tenuior L. essential oil against multidrug-resistant Acinetobacter baumannii. Inernational Journal of Pharmacology, 12, 28–23.
  • • Cho, N., Ransom, T. T., Sigmund, J., Tran, T., Cichewicz, R. H., Goetz, M., & Beutler, J. A. (2017). Growth inhibition of colon cancer and melanoma cells by versiol derivatives from a paraconiothyrium species. Journal of Natural Products, 80(7), 2037–2044.
  • • Clinical and Laboratory Standards Institute. (1997). Reference method for broth dilution antifungal susceptibility testing of yeasts; Approved standard–Second Edition; M27-A2. Wayne, PA: Author.
  • • Clinical and Laboratory Standards Institute. (2006). Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 7th ed.; Approved standard M7-A7. Wayne, PA: Author.
  • • Clinical and Laboratory Standards Institute. (2010). Performance standards for antimicrobial susceptibility testing: 7th informational supplement; M100-S20. Wayne, PA: Author.
  • • Ellman, G. L., Courtney, K. D., Andres Jr, V., & Featherstone, R. M. (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology, 7(2), 88–95.
  • • Ghanbarian, G., Jafari, E., & Bahmanzadegan, A. (2017). Essential oil composition of aerial parts of Ziziphora clinopodioides Lam. from Western of Shiraz, Iran. Analytical Chemistry Letters, 7(3), 383–388.
  • • Gursoy, N., Sihoglu-Tepe, A., & Tepe, B. (2009). Determination of in vitro antioxidative and antimicrobial properties and total phenolic contents of Ziziphora clinopodioides, Cyclotrichium niveum, and Mentha longifolia ssp. typhoides var. typhoides. Journal of Medicinal Food, 12(3), 684–689.
  • • Hamedi, H., Kargozari, M., Shotorbani, P. M., Mogadam, N. B., & Fahimdanesh, M. (2017). A novel bioactive edible coating based on sodium alginate and galbanum gum incorporated with essential oil of Ziziphora persica: The antioxidant and antimicrobial activity, and application in food model. Food Hydrocolloids, 72, 35–46.
  • • Hearing, V. J., & Jiménez, M. (1987). Mammalian tyrosinase-the critical regulatory control point in melanocyte pigmentation. International Journal of Biochemistry, 19(12), 1141–1147.
  • • Heinrich, M., & Gibbons, S. (2001). Ethnopharmacology in drug discovery: An analysis of its role and potential contribution. Journal of Pharmacy and Pharmacology, 53(4), 425-432.
  • • Kaya, A., & Dirmenci, T. (2012). Nutlet morphology of Turkish Ziziphora L. (Lamiaceae). Plant Biosystems-An International Journal Dealing with all Aspects of Plant Biology, 146(3), 560–563.
  • • Kheirkhah, M., Ghasemi, V., Yazdi, A. K., & Rahban, S. (2015). Chemical composition and insecticidal activity of essential oil from Ziziphora clinopodioides Lam. used against the Mediterranean flour moth, Ephestia kuehniella Zeller. Journal of Plant Protection Research, 55(3), 260–265.
  • • Khodaverdi-Samani, H., Pirbalouti, A. G., Shirmardi, H.-A., & Malekpoor, F. (2015). Chemical composition of essential oils of Ziziphora clinopodioides Lam.(endemic Iranian herb) collected from different natural habitats. Indian Journal of Traditional Knowledge, 1(1), 57–62.
  • • Ma, B.-X., Ban, X.-Q., He, J.-S., Huang, B., Zeng, H., Tian, J. & Wang, Y.-W. (2016). Antifungal activity of Ziziphora clinopodioides Lam. essential oil against Sclerotinia sclerotiorum on rapeseed plants (Brassica campestris L.). Crop Protection, 89, 289–295.
  • • Mahboubi, A., Kamalinejad, M., Ayatollahi, A. M., & Babaeian, M. (2014). Total phenolic content and antibacterial activity of five plants of Labiatae against four foodborne and some other bacteria. Iranian Journal of Pharmaceutical Research, 13(2), 559–566.
  • • Maral, H., Taghikhani, H., Kaya, A., & Kırıcı, S. (2015). The effect of different levels of altitutes on composition and content of essential oils of Ziziphora clinopodioides in southern Turkey. International Journal of Agriculture and Wildlife Science, 1(1), 1–6.
  • • Miller, H. (1971). A simplified method for the evaluation of antioxidants. Journal of the American Oil Chemists Society, 48(2), 91.
  • • Mohammadhosseini, M., Akbarzadeh, A., Hashemi-Moghaddam, H., Shahnama, M., Fahimi, B., & Azami, S. (2016). Gas chromatographic-mass spectrometric analysis of volatiles obtained by HSSPME-GC-MS technique from aerial parts of Ziziphora capitata L., and evaluation for biological activity. Oriental Journal of Chemistry, 32(3), 1439–1451.
  • • Moreno, M. a. I. N., Isla, M. a. I., Sampietro, A. R., & Vattuone, M. A. (2000). Comparison of the free radical-scavenging activity of propolis from several regions of Argentina. Journal of Ethnopharmacology, 71(1–2), 109–114.
  • • Nickavar, B., & Tavakoli, F. (2016). Comparative analysis of volatile constituents from two Ziziphora clinopodioides subspecies (Z. clinopodioides subsp. elbursensis and Z. clinopodioides subsp. filicaulis). Journal of Essential Oil Bearing Plants, 19(8), 2072–2076.
  • • Okut, N., Selcuk, N., Yagmur, M., & Yildirim, B. (2018). Chemical diversity of essential oil from leaves of Ziziphora clinopodioides growing in Van, Turkey. Fresenius Environmental Bulletin, 2785–2790.
  • • Ozdemir, A., Turkoglu, V., & Demir, H. (2013). In vitro effect of some plant extracts on acetylcholinesterase enzyme in human erythrocytes and serum. Fresenius Environmental Bulletin, 22(9), 2510–2515.
  • • Ozturk, S., & Ercisli, S. (2007). Antibacterial activity and chemical constitutions of Ziziphora clinopodioides. Food Control, 18(5), 535–540.
  • • Pakdel, F., Ghasemi, S., Babaloo, A., Javadzadeh, Y., Momeni, R., Ghanizadeh, M. & Fathi, F. Y. (2017). Antibacterial effects of garlic • extracts and Ziziphora essential oil on bacteria associated with • peri-Implantitis. Journal of Clinical and Diagnostic Research, 11(4), ZC16–ZC19.
  • • Re, R., Pellegrini, N., Proteggente, A., Pannala, A., Yang, M., RiceEvans, C. J. F. r. b., & medicine. (1999). Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biology and Medicine, 26(9–10), 1231–1237.
  • • Salehi, P., Sonboli, A., Eftekhar, F., Nejad-Ebrahimi, S., & Yousefzadi, M. (2005). Essential oil composition, antibacterial and antioxidant activity of the oil and various extracts of Ziziphora clinopodioides subsp. rigida (BOISS.) RECH. f. from Iran. Biological and Pharmaceutical Bulletin, 28(10), 1892-1896.
  • • Selvi, S., Satil, F., Martin, E., Celenk, S., & Dirmenci, T. (2015). Some evidence for infrageneric classification in Ziziphora L. (Lamiaceae: Mentheae). Plant Biosystems-An International Journal Dealing with all Aspects of Plant Biology, 149(2), 415–423.
  • • Shahbazi, Y. (2015). Chemical composition and in vitro antibacterial effect of Ziziphora clinopodioides essential oil. Pharmaceutical Sciences, 21(2), 51–56.
  • • Shahbazi, Y., Shavisi, N., & Mohebi, E. (2017). Antibacterial activity of Ziziphora clinopodioides essential oil and nisin against Bacillus subtilis and Salmonella typhimurium in commercial barley soup. Bulgarian Journal of Veterinary Medicine, 20(1), 65–72.
  • • Tian, S., Shi, Y., Zhou, X., Ge, L., & Upur, H. (2011). Total polyphenolic (flavonoids) content and antioxidant capacity of different Ziziphora clinopodioides Lam. extracts. Pharmacognosy Magazine, 7(25), 65–68.
  • • Unal, E. L., Mavi, A., Kara, A. A., Cakir, A., Şengül, M., & Yildirim, A. (2008). Antimicrobial and antioxidant activities of some plants used as remedies in Turkish traditional medicine. Pharmaceutical Biology, 46(3), 207–224.
  • • Yilmaz, M. A., Ertas, A., Yener, I., Akdeniz, M., Cakir, O., Altun, M., Demirtas, I., Boga, M., & Temel, H. (2018). A comprehensive LC– MS/MS method validation for the quantitative investigation of 37 fingerprint phytochemicals in Achillea species: A detailed examination of A. coarctata and A. monocephala. Journal of Pharmaceutical and Biomedical Analysis, 154, 413–424.
  • • Zahid, H., Rizwani, G. H., Kamil, A., Shareef, H., Tasleem, S., & Khan, A. (2015). Anti-urease activity of Mimusops elengi Linn (Sapotaceae). European Journal of Medicinal Plants, 6(4), 223–230.
  • • Zhang, X.-M., An, D.-Q., Guo, L.-L., Yang, N.-H., & Zhang, H. (2019). Identification and screening of active components from Ziziphora clinopodioides Lam. in regulating autophagy. Natural Product Research, 33(17), 2549–2553.
Toplam 41 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık ve İlaç Bilimleri, Sağlık Kurumları Yönetimi
Bölüm Original Article
Yazarlar

Esra Eroğlu Özkan Bu kişi benim 0000-0002-1569-2535

Mehmet Boğa Bu kişi benim 0000-0003-4163-9962

Mustafa Abdullah Yılmaz Bu kişi benim 0000-0002-4090-7227

Emel Mataracı Kara Bu kişi benim 0000-0003-4541-1893

Yeter Yeşil Bu kişi benim 0000-0002-4458-7881

Yayımlanma Tarihi 1 Nisan 2020
Gönderilme Tarihi 18 Ekim 2019
Yayımlandığı Sayı Yıl 2020 Cilt: 50 Sayı: 1

Kaynak Göster

APA Eroğlu Özkan, E., Boğa, M., Yılmaz, M. A., Mataracı Kara, E., vd. (2020). LC-MS/MS analyses of Ziziphora clinopodioides Lam. from Turkey: Antioxidant, anticholinesterase, antimicrobial and, anticancer activities. İstanbul Journal of Pharmacy, 50(1), 33-41.
AMA Eroğlu Özkan E, Boğa M, Yılmaz MA, Mataracı Kara E, Yeşil Y. LC-MS/MS analyses of Ziziphora clinopodioides Lam. from Turkey: Antioxidant, anticholinesterase, antimicrobial and, anticancer activities. iujp. Nisan 2020;50(1):33-41.
Chicago Eroğlu Özkan, Esra, Mehmet Boğa, Mustafa Abdullah Yılmaz, Emel Mataracı Kara, ve Yeter Yeşil. “LC-MS/MS Analyses of Ziziphora Clinopodioides Lam. From Turkey: Antioxidant, Anticholinesterase, Antimicrobial And, Anticancer Activities”. İstanbul Journal of Pharmacy 50, sy. 1 (Nisan 2020): 33-41.
EndNote Eroğlu Özkan E, Boğa M, Yılmaz MA, Mataracı Kara E, Yeşil Y (01 Nisan 2020) LC-MS/MS analyses of Ziziphora clinopodioides Lam. from Turkey: Antioxidant, anticholinesterase, antimicrobial and, anticancer activities. İstanbul Journal of Pharmacy 50 1 33–41.
IEEE E. Eroğlu Özkan, M. Boğa, M. A. Yılmaz, E. Mataracı Kara, ve Y. Yeşil, “LC-MS/MS analyses of Ziziphora clinopodioides Lam. from Turkey: Antioxidant, anticholinesterase, antimicrobial and, anticancer activities”, iujp, c. 50, sy. 1, ss. 33–41, 2020.
ISNAD Eroğlu Özkan, Esra vd. “LC-MS/MS Analyses of Ziziphora Clinopodioides Lam. From Turkey: Antioxidant, Anticholinesterase, Antimicrobial And, Anticancer Activities”. İstanbul Journal of Pharmacy 50/1 (Nisan 2020), 33-41.
JAMA Eroğlu Özkan E, Boğa M, Yılmaz MA, Mataracı Kara E, Yeşil Y. LC-MS/MS analyses of Ziziphora clinopodioides Lam. from Turkey: Antioxidant, anticholinesterase, antimicrobial and, anticancer activities. iujp. 2020;50:33–41.
MLA Eroğlu Özkan, Esra vd. “LC-MS/MS Analyses of Ziziphora Clinopodioides Lam. From Turkey: Antioxidant, Anticholinesterase, Antimicrobial And, Anticancer Activities”. İstanbul Journal of Pharmacy, c. 50, sy. 1, 2020, ss. 33-41.
Vancouver Eroğlu Özkan E, Boğa M, Yılmaz MA, Mataracı Kara E, Yeşil Y. LC-MS/MS analyses of Ziziphora clinopodioides Lam. from Turkey: Antioxidant, anticholinesterase, antimicrobial and, anticancer activities. iujp. 2020;50(1):33-41.