The levels of serum vascular endothelial growth factor and Bcl-2 and association between them in stage IV non-small cell lung cancer

Öz

OBJECTIVES In most of the tumors, vascular endothelial growth fact o r (VEGF) shows its ang io g enic effects by increasing the level of the Bcl-2 onc o protein. The aim of this study was to inv e st ig ate the serum levels of VEGF and Bcl-2 and the possible association betw een them in stage III and stage IV non-small cell lung cancer (NSCLC). METHODS Twenty eight patients in stage III, 24 patients in stage IV and 25 healthy subjects were enrolled in the study. Serum Bcl-2 and VEGF levels were analyzed by ELISA. RESULTS The VEGF (pg/ml) level in stage IV (11 6.7± 151.7) and stage III ( 11 6.2 ± 1 4 0.6) patients was higher than healthy subjects ( 34.5 ± 6.3) (p

Anahtar Kelimeler

• Carcinoma, Non-Small-Cell Lung,Vascular Endothelial Growth Factor A,Proto-Oncogene Proteins c-bcl-2,Neoplasm Staging

Evre IV küçük hücreli dışı akciğer kanserinde serum vasküler endotelyal büyüme faktörü ve Bcl-2 düzeyleri ve aralarındaki ilişki

Öz

AMAÇ Tümörlerin çoğunda vasküler endotelyal büyüme faktör (VEBF) angiogenik etkisini Bcl-2 onkoproteinini artırarak göstermektedir. Bu çalışmadaki amacımız evre III ve evre IV hücreli dışı akc iğer kans eri'nde (KHDAK) VEBF ve Bcl-2 düzeylerini ve aralarındaki olası ilişkiyi araştırmaktır. GEREÇ VE YÖNTEM Çalışmaya 28 evre III ve 24 evre IV KHDAK'li hasta ile kontrol grubuna sağlıklı 25 kişi alındı. ELISA yöntemi ile serum VEBF ve Bcl-2 düzeyleri çalışıldı. BULGULAR VEBF (pg/ml) düzeyi evre IV (116.7±151.7) ile evre III (116.2±140.6) hastalarda kontrollere (34.5±6.3) göre oldukça yüksek bulundu (p < 0.0001). Evre IV ile evre III arasında VEBF açısından bir farklılık saptanmadı. Üç grupta ölçülen Bcl-2 düzeyi farklı değildi (p=0.15). Grupların hiçbirinde VEBF ile Bcl-2 arasında anlamlı bir ilişki saptanmadı (p=0.109). SONUÇ Evre IV KHDAK’li hastalarda VEBF düzeyi evre III hastalardan daha yüksek değildi. Evre IV KHDAK’li hastalarda VEBF ile Bcl-2 arasında olası ilişkiyi ortaya çıkarmak için daha fazla angiogenik, antiapoptotik sitokin ve daha fazla hasta ile yapılan çalışmalara ihtiyaç olduğu düşüncesindeyiz.

Anahtar Kelimeler

• Küçük hücreli dışı akciğer kanseri, vasküler endotelyal büyüme faktörü, Bcl-2.

Kaynakça

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