Synchronous metastasis of metachronous tumor: A case report

Abstract

Recent advancements in cancer treatment have increased the incidence of secondary tumors and metachronous tumors by means of improving survival rates. Increased risk of secondary cancer is observed after radiotherapy and chemotherapy episodes. It is a clinical observation to now encounter recurrences many years after a successful treatment or a primary resection of a tumor. How a tumor cell persists alive but stable and how it demonstrates its tumorigenic potential remain to be clarified. A patient with colon adenocarcinoma and coexisting malignant melanoma who presented synchronic metastasis in the follow-up is presented in this manuscript.

Keywords

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Metakron tümörde senkron metastaz: Olgu sunumu

Öz

Son zamanlarda kanser tedavisindeki ilerlemeler hastaların kanserden kür olmalarını sağlayarak sağkalım süreçlerini artırdığı için ikinci tümör, metakron tümör görülme insidansında da artışa neden olmuştur. İkincil kanser risk artışı, radyoterapi, kemoterapi veya kombine tedaviler sonrasında gözlenmiştir. Başarılı bir tedavi ya da primer tümörün başarıyla çıkarılmasından yıllar sonra nüks görülmesi sık bir klinik gözlemdir. Tümör hücresinin sabit ancak canlı kalması ve daha sonraki bir zamanda tümörojenik potansiyelini göstermesi hala açıklanamamış bir konudur. Yazımızda kolon adenokarsinom karaciğer metastazı ve malign melanom tanısı ile izlenen, takibinde senkron metastaz saptanan olgu sunuldu.

Anahtar Kelimeler

• İkincil tümör, karsinom, metakron tümör, senkron tümör

Kaynakça

1. 1. van Bodegom PC, Wagenaar SS, Corrin B, Baak JP, Berkel J, Vanderschueren RG. Second primary lung cancer: importance of long term follow up. Thorax 1989;44(10):788-93.
2. 2. Van Leeuwen FE, Travis LB. Second cancers. In: De Vita VT, Hellman S, Rosenberg SA, editors. Cancer, Principles and Practice of Oncology. 6th edition. Philadelphia: Lippincott-Williams&Wilkins; 2001. p. 2939-64.
3. 3. Tsukuma H, Fujimoto I, Hanai A, Hiyama T, Kitagawa T, Kinoshita N. Incidence of second primary cancers in Osaka residents, Japan, with special reference to cumulative and relative risks. Jpn J Cancer Res 1994;85(4):339-45.
4. 4. Minagawa M, Makuuchi M, Torzilli G, Takayama T, Kawasaki S, Kosuge T, et al. Extension of the frontiers of surgical indications in the treatment of liver metastases from colorectal cancer: long-term results. Ann Surg 2000;231(4):487-99.
5. 5. Nordlinger B, Quilichini MA, Parc R, Hannoun L, Delva E, Huguet C. Hepatic resection for colorectal liver metastases. Influence on survival of preoperative factors and surgery for recurrences in 80 patients. Ann Surg 1987;205(3):256-63.
6. 6. Pfannschmidt J, Muley T, Hoffmann H, Dienemann H. Prognostic factors and survival after complete resection of pulmonary metastases from colorectal carcinoma: experiences in 167 patients. J Thorac Cardiovasc Surg 2003;126(3):732-9.
7. 7. Murata S, Moriya Y, Akasu T, Fujita S, Sugihara K. Resection of both hepatic and pulmonary metastases in patients with colorectal carcinoma. Cancer 1998;83(6):1086-93.
8. 8. Cotran RS, Kumar V, Robbins SL. Genetic disorders. In: Cotran RS, Kumar V, Robins SL, editors. Robbins pathologic basis of disease. P h i l a d e l p h i a: W. B . Saunders Company; 1989. p. 121-62.

9. 9. Barth A, Wanek LA, Morton DL. Prognostic factors in 1,521 melanoma patients with distant metastases. J Am Coll Surg 1995;181(3):193-201.
10. 10. Landis SH, Murray T, Bolden S, Wingo PA. Cancer statistics, 1998. CA Cancer J Clin 1998;48(1):6-29.
11. 11. Sorensen JB. Endobronchial metastases from extrapulmonary solid tumors. Acta Oncol 2004;43(1):73-9.
12. 12.Briones Gómez A, Cases Viedma E, Doménech Clar R, Sanchis Aldás JL. Pulmonary metastases of malignant melanoma. A rare endobronchial presentation. [Article in Spanish] Arch Bronconeumol 1999;35(9):455-7. [Abstract]
13. 13. Akçay fi, Demirhan B. An unusual case of bronchogenic carcinoma and oral cavity cancer: Metastatic oral cavity disease or a second primary tumor. Turkish Respiratory Journal 2000;1:75-8.
14. 14. Albelda SM. Role of integrins and other cell adhesion molecules in tumor progression and metastasis. Lab Invest 1993;68(1):4-17.
15. 15. De Vita VT, Hellman S, Rosenberg SA. Metastatic cancer to the lung. In: Putnam JB Jr, editor. Cancer, priciples and practice of on c o l o g y. 6 t h e d . Philadelphia: Lippincott Williams & Wilkins; 2001. p. 2670-89.