Cancer stem cells in solid tumors and leukemia

Abstract

Cancer stem cells (CSCs) are cells that drive tumorigenesis, as well as give rise to a large population of differentiated progeny that make up the bulk of the tumor. The same specific signaling pathways play a functional role in CSC renewal and/or differentiation as with normal stem cells, the only difference being that the same signaling pathways are dysregulated in CSCs. In addition, recent studies have demonstrated that CSCs are resistant to chemo- and radiotherapy. Future studies should lead to development of CSC-targeted therapies for cancer treatment.

Keywords

• -

Solid tümörlerde ve lösemilerde kanser kök hücreleri

Öz

Kanser kök hücreleri (KKH) tümörün başlangıcından sorumlu olan ve tümör dokusundaki çok sayıda farklılaşmış hücre topluluğ unu oluşturan hücrelerdir. Aynı özgü sinyal ileti sistemleri KKH'lerin ve normal kök hücrelerinin kendi-kendini yenileme ve/veya farklılaşmasında fonksiyonel rol oynarlar. Aralarındaki başlıca fark; KKH'lerde aynı sinyal ileti sistemlerinin düzenlenmesi değişmektedir. Son çalışmalarla KKH'lerin ilaç ve radyasyon tedavisine dirençli oldukları gösterilmiştir. Gelecekteki çalışmalar kanserin tedavisi için KKH'leri hedef alan tedavilerin geliştirilmesine öncülük edecektir.

Anahtar Kelimeler

• Kanser kök hücresi, kanser kök hücresi belirteçleri, normal kök hücre

Kaynakça

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