Approach to small cell lung cancer

Yıl 2007, Cilt: 22 Sayı: 1, 44 - 53, 01.02.2007

Mustafa Altınbaş Mustafa Dikilitaş Metin Özkan Gamze Gököz Doğu Özlem Er

Öz

Small cell lung cancer (SCLC) is distinguished by non-small cell lung cancer (NSCLC) by its' biological behaviour, management and prognosis. As the disease is commonly in extended form and distant metastasis and regional lymph node involvement are present at the time of diagnosis SCLC is assumed as a systemic disease. Studies concerning with understanding the molecular and genetic characteristics of the disease may change the treatment modalities. Despite the efforts to develope new and effective treatment options, standart management of limited disease remained unchanged during the last fifteen years. On the other hand there are ongoing studies for the treatment of extended disease. However, prevention of cigarette smoking is still the best practice.

Anahtar Kelimeler

Carcinoma, Small Cell, Lung Neoplasms, Chemotherapy, Smoking

Küçük hücreli akciğer kanserine yaklaşım

Öz

Küçük hücreli akciğer kanseri (KHAK) biyolojik davranışı, tedavi şekli ve prognozu açısından küçük hücreli dışı akciğer kanserlerinden ayrılır. Tanı anında çoğunlukla yaygın hastalık evresinde olması, uzak organ metastazı ve bölgesel lenf bezi tutulumu bulunması nedeniyle sistemik bir hastalık kabul edilir. Hastalığın genetik ve moleküler özelliklerini anlamaya yönelik çalışmalar sonuçlandığında tedavi yaklaşımlarımız değişebilecektir. Yeni ve daha etkin tedavi arayışlarına karşın sınırlı hastalık evresinde 15 yıldır kemoterapi standartı değişmemiştir. Yaygın hastalıkta yeni tedavi arayışları ise sürmektedir. Akciğer kanseri için sigara ile mücadele hala en etkili yöntemdir.

Anahtar Kelimeler

Küçük hücreli akci¤er kanseri, kemoterapi.

Kaynakça

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