Gemcitabine and carboplatin combination in patients with advanced and locally advanced stage non-small cell lung cancer

Yıl 2008, Cilt: 23 Sayı: 2, 72 - 80, 01.03.2008

Nevzat Öztürk Ahmet Emin Erbaycu Mehmet Gülpek Fevziye Tuksavul Özgür Uslu Salih Zeki Güçlü

Öz

OBJECTIVES The aim was to evaluate the efficacy, toxicity and survival results of gemcitabine and carboplatin (GCa) combination in patients with advanced and locally advanced non-small cell lung cancer (NSCLC). METHODS Forty-one patients (40 males, 1 female; mean age 59; range 43 to 72 years) diagnosed histopathologically, with good performance and without previous chemotherapy were included in the study. RESULTS Complete response (CR) was observed in 2.4% and partial response (PR) in 34.1%. CR and PR were found in 4.2% and 41.7% in stage IIIB, and in 0% and 23.5% in stage IV. The mean survival and one-year survival rates were 14 months and 54.2% in stage IIIB, and 10 months and 29.4% in stage IV. In general, the mean survival and one-year survival rates were 11 months and 43%. GCa most frequently caused grade-1 anemia (21.2%) in 165 chemotherapy cycles. CONCLUSION GCa in advanced and locally advanced NSCLC is a well-tolerated, effective alternative with its moderate toxicity

Anahtar Kelimeler

Gemcitabine, Carboplatin, Carcinoma, Non-Small-Cell Lung, Survival, Drug Toxicity

İleri ve lokal ileri evre küçük hücreli dışı akciğer kanserinde gemsitabin ve karboplatin kombinasyonu

Öz

AMAÇ İleri ve lokal ileri evre küçük hücreli dışı akciğer kanserinde (KHDAK) gems it abin (G) ve karb o pl atin (Ca) komb inasyonunun ant itümör etk i nliği, toks is it esi ve yaşam sür esi sonuçl arı değerlendirildi. GEREÇ VE YÖNTEM Histopatolojik olarak KHDAK teşhis edilen, ECOG 0-2 performansında olan daha önce kemoterapi uygulanmamış 41 hasta (40 erkek, 1 kadın; ort. yaş 59; dağılım 43-72) çalışmaya alındı. BULGULAR Tam yanıt (CR) %2,43 ve kısmi yanıt (PR) %34,1 oranında oldu. Evre IIIB'de CR %4,2, PR %41,7, evre IV'de CR %0 ve PR %23,5; evre IIIB'de ortalama yaşam süresi 14 ay ve bir yıllık sağkalım %54,2 iken, evre IV'de 10 ay ve %29,4 bulundu. Genel olarak, ortalama yaşam süresi 11 ay ve bir yıllık sağkalım %43 oldu. Yüz altmış beş kür GCa tedavisi sonrası en sık (%21,2) görülen ilaç toksisitesi grade-1 anemi oldu. En sık (%7,87) hematolojik olmayan toksisite bulantı ve kusma idi. SONUÇ Gemsitabin ve karboplatin, ileri ve lokal ileri evre KHDAK'de iyi tolere edilen, ılımlı toksisitesi ile etkin bir alternatif kombinasyondur.

Anahtar Kelimeler

Gemsitabin, karboplatin, küçük hücreli dışı akciğer kanseri, toksisite, yaşam süresi.

Kaynakça

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