Ganglioglioma: A case report

Yıl 2008, Cilt: 23 Sayı: 3, 142 - 146, 01.04.2008

Ali Özcan Binatlı Erel Uluğ İlker Özhan Deniz Altınel Nurcan Özdamar

Öz

Gangliogliomas are mixed neuronal-glial type tumors of the central nervous system (CNS). Gangliogliomas are rare tumors that present histological features and biological behavior of low-grade malignancy. Gangliogliomas account for about 0.5% of all CNS tumors, and they generally occur in childhood. Gangliogliomas make up about 8.0% of CNS tumors in children. These tumors are mostly localized in the supratentorial region and often present with seizures. Surgery is the first choice of treatment. We present a case of a 14-yearold male who presented with headache, with vomiting added recently. A left temporal mass was detected during investigations. The mass was totally resected surgically. The pathology was reported as ganglioglioma. The patient is being followed sufficiently in our clinic.

Anahtar Kelimeler

Ganglioglioma, Adolescent, Male, Radiotherapy, Magnetic Resonance Imaging, Surgical Procedures, Operative

Gangliogliom: Olgu sunumu

Öz

Gangliogliomlar, merkezi sinir sisteminin (MSS) mikst nöronal glial tümörlerindendir. Nadir görülen bu tümörler, histolojik özellik ve biyolojik davranış olarak düşük derece malignite gösterirler. Gangliogliomlar, tüm MSS tümörlerinin yaklaşık %0,5'ini oluştururlar. Genellikle çocukluk çağında görülürler. Çocuklardaki MSS tümörlerinin yaklaşık %8'ini oluştururlar. Daha sıklıkla supratentorial yerleşim gösteren bu tümörler, en sık nöbet şikayetine yol açarlar. Cerrahi, tedavide ilk seçenektir. Bu yazıda, baş ağrısı ve kusma yakınmaları olan 14 yaşındaki erkek hasta sunuldu. Yapılan incelemeler sonucunda olguda sol temporal kitle saptandı. Kitle, ameliyatla total rezeke edildi. Patoloji incelemesinde gangliogliom olarak rapor edildi. Olgunun takibine devam edilmektedir.

Anahtar Kelimeler

Cerrahi, gangliogliom, radyoterapi

Kaynakça

• 1. Hakim R, Loeffler JS, Anthony DC, Black PM. Gangliogliomas in adults. Cancer 1997;79(1):127-31.
• 2. Kalyan-Raman UP, Olivero WC. Ganglioglioma: a correlative clinicopathological and radiological study of ten surgically treated cases with follow-up. Neurosurgery 1987;20(3):428-33.
• 3. P e r e t t i - Viton P, Perez-Castillo AM, Raybaud C, Grisoli F, Bernard F, Poncet M, et al. Magnetic resonance imaging in gangliogliomas and gangliocytomas of the nervous system. [Article in English, French] J Neuroradiol 1991;18(2):189-99.
• 4. Haddad SF, Moore SA, Menezes AH, VanGilder JC. Ganglioglioma: 13 years of experience. Neurosurgery 1992;31(2):171-8.
• 5. Lang FF, Epstein FJ, Ransohoff J, Allen JC, Wisoff J, Abbott IR, et al. Central nervous system gangliogliomas. Part 2: Clinical outcome. J Neurosurg 1993;79(6):867-73.
• 6. Miller DC, Lang FF, Epstein FJ. Central nervous system gangliogliomas. Part 1: Pathology. J Neurosurg 1993;79(6):859-66.
• 7. Prayson RA, Khajavi K, Comair YG. Cortical architectural abnormalities and MIB1 immunoreactivity in gangliogliomas: a study of 60 patients with intracranial tumors. J Neuropathol Exp Neurol 1995;54(4):513-20.
• 8. Zentner J, Wolf HK, Ostertun B, Hufnagel A, Campos MG, Solymosi L, et al. Gangliogliomas: clinical, radiological, and histopathological findings in 51 patients. J Neurol Neurosurg Psychiatry 1994;57(12):1497- 502.
• 9. Silver JM, Rawlings CE 3rd, Rossitch E Jr, Zeidman SM, Friedman AH. Ganglioglioma: a clinical study with long-term follow-up. Surg Neurol 1991;35(4):261-6.
• 10.Johannsson JH, Rekate HL, Roessmann U. Gangliogliomas: pathological and clinical correlation. J Neurosurg 1981;54(1):58-63.
• 11. Ya s a rgil MG, von Ammon K, von Deimling Valavanis A, Wichmann W, Wiestler OD. Central neurocytoma: histopathological variants and therapeutic approaches. J Neurosurg 1992;76(1):32-7.
• 12. Dash RC, Provenzale JM, McComb RD, Perry DA, Longee DC, McLendon RE. Malignant supratentorial ganglioglioma (ganglion cell-giant cell glioblastoma): a case report and review of the literature. Arch Pathol Lab Med 1999;123(4):342-5.
• 13.Russel DS, Rubinstein LJ. Pathology of tumours of the nervous sys-tem. 5th ed. Baltimore: Williams and Wilkins; 1989. p. 289-350.
• 14. Ventureyra E, Herder S, Mallya BK, Keene D. Temporal lobe gangliogliomas in children. Childs Nerv Syst 1986;2(2):63-6.
• 15. Wolf HK, Müller MB, Spänle M, Zentner J, Schramm J, Wiestler OD. Ganglioglioma: a detailed histopathological and immunohistochemical analysis of 61 cases. Acta Neuropathol 1994;88(2):166-73.
• 16.Jay V, Squire J, Blaser S, Hoffman HJ, Hwang P. Intracranial and spinal metastases from a ganglioglioma with unusual cytogenetic abnormalities in a patient with complex partial seizures. Childs Nerv Syst 1997;13(10):550-5.
• 17. Sutton LN, Packer RJ, Rorke LB, Bruce DA, Schut L. Cerebral gangliogliomas during childhood. Neurosurgery 1983;13(2):124-8.
• 18. Hirose T, Scheithauer BW, Lopes MB, Gerber HA, Altermatt HJ, VandenBerg SR. Ganglioglioma: an ultrastructural and immunohistochemical study. Cancer 1997;79(5):989-1003.
• 19.Jay V, Becker LE, Otsubo H, Hwang PA, Hoffman HJ, Harwood-Nash D. Pathology of temporal lobectomy for refractory seizures in children. Review of 20 cases including some unique malformative lesions. J Neurosurg 1993;79(1):53-61.
• 20. Araki M, Fan J, Haraoka S: Extracranial metastasis of anaplastic ganglioglioma through a ventriculoperitoneal shunt; A case report. Pathol Int. 49:258-263, 1999.
• 21.Castillo M, Davis PC, Takei Y, Hoffman JC Jr. Intracranial ganglioglioma: MR, CT, and clinical findings in 18 patients. AJNR Am J Neuroradiol 1990;11(1):109-14.
• 22. Tamiya T, Hamazaki S, Ono Y, Tokunaga K, Matsumoto K, Furuta T, et al. Ganglioglioma in a patient with Turcot syndrome. Case report. J Neurosurg 2000;92(1):170-5.
• 23.Burger PC, Scheithauer BW. Atlas of tumor patholog y. Tumors of the Central Nervous System. Washington, D.C.: Armed Forces Insti-tute of Pathology; 1994. p. 163-72.
• 24. Suzuki H, Otsuki T, Iwasaki Y, Katakura R, Asano H, Tadokoro M, et al. Anaplastic ganglioglioma with sarcomatous component: an immunohistochemical study and molecular analysis of p53 tumor suppressor gene. Neuropathology 2002;22(1):40-7.
• 25. Kurian NI, Nair S, Radhakrishnan VV. Anaplastic ganglioglioma: case report and review of the literature. Br J Neurosurg 1998;12(3):277-80.
• 26. Kroh H, Matyja E, Bidzinski J. Cerebral gangliogliomas. Morphological and immunohistochemical study. Folia Neuropathol 1996;34(2):107-13.