Lacrimal gland adenoid cystic carcinoma treated with intraarterial chemotherapy

Yıl 2009, Cilt: 24 Sayı: 3, 128 - 130, 01.04.2009

Bülent Karagöz Oğuz Bilgi Cengiz Duman Çınar Başekim Emin Gökhan Kandemir Abdullah Haholu Alpaslan Özgün Orhan Türmen

Öz

Adenoid cystic carcinoma is a malignant tumor of glandular tissue and progresses with local relapse and distant metastasis. In this report, we present a case of lacrimal gland adenoid cystic carcinoma who treated by multimodal approach with intraarterial chemotherapy. A 32-year-old woman was diagnosed with adenoid cystic carcinoma (solid variant) of the left lacrimal gland. Neoadjuvant intraarterial cisplatin, intravenous doxorubicin, and orbital exenteration were performed. The patient was followed for 32 months without relapse. Achievement of long-time survival for this disease supports studies that show benefit of intraarterial chemotherapy.

Anahtar Kelimeler

-

İntraarteriyel kemoterapi ile tedavi edilen lakrimal gland adenoid kistik karsinomu olgusu

Öz

Adenoid kistik karsinom (AKK) lokal nüks ve uzak metastazlarla seyreden glanduler dokuların malign tümörüdür. Bu yazıda, intraarteriyel kemoterapi ile beraber multimodal yaklaşımla tedavi edilen bir lakrimal gland AKK olgusu sunuldu. Otuz iki yaşındaki kadın hastaya sol lakrimal gland AKK (solid varyant) tanısı konuldu. Neoadjuvan intraarteriyel sisplatin ve intravenöz doksorubisin tedavisinden sonra orbita eksanterasyonu uygulandı. Hasta 32 ay sonra halen hastalıksız izlemdedir. Söz konusu hastalık için iyi bir hastalıksız sağkalım süresi sağlanması, lakrimal gland AKK tedavisinde intraarteriyel kemoterapinin yararını gösteren yayınları destekler durumdadır.

Anahtar Kelimeler

Adenoid kistik karsinom, intraarteryal kemoterapi, lakrimal gland

Kaynakça

• 1. Font RL, Smith SL, Bryan RG. Malignant epithelial tumors of the lacrimal gland: a clinicopathologic study of 21 cases. Arch Ophthalmol 1998;116(5):613-6.
• 2. Zeidan BA, Hilal MA, Al-Gholmy M, El-Mahallawi H, Pearce NW, Primrose JN. Adenoid Cystic Carcinoma of the lacrimal gland metastasising to the liver: report of a case. World J Surg Oncol 2006;4:66.
• 3. Seethala RR, Hunt JL, Baloch ZW, Livolsi VA, Leon Barnes E. Adenoid cystic carcinoma with high-grade transformation: a report of 11 cases and a review of the literature. Am J Surg Pathol 2007;31(11):1683-94.
• 4. Esmaeli B, Ahmadi MA, Youssef A, Diba R, Amato M, Myers JN, et al. Outcomes in patients with adenoid cystic carcinoma of the lacrimal gland. Ophthal Plast Reconstr Surg 2004;20(1):22-6.
• 5. Esmaeli B, Golio D, Kies M, DeMonte F. Surgical management of locally advanced adenoid cystic carcinoma of the lacrimal gland. Ophthal Plast Reconstr Surg 2006;22(5):366-70.
• 6. Meldrum ML, Tse DT, Benedetto P. Neoadjuvant intracarotid chemotherapy for treatment of advanced adenocystic carcinoma of the lacrimal gland. Arch Ophthalmol 1998;116(3):315-21