BibTex RIS Kaynak Göster

Cytomegalovirus pneumonia in a pediatric patient with solid tumor

Yıl 2009, Cilt: 24 Sayı: 2, 85 - 87, 01.03.2009

Halil Haldun Emiroğlu Rejin Kebudı Bülent Zülfikar Ömer Görgün Gülden Yılmaz İnci Ayan Nuran Salman Ayper Somer

Öz

Cytomegalovirus (CMV) infection is an important cause of morbidity and mortality in immunosuppressed patients. CMV infection is mostly encountered in children undergoing highdose chemotherapy and transplantation. Though the chemotherapy for solid tumor is an immunosuppressed state, CMV infection has been reported infrequently in children with solid tumors. In this paper, a child diagnosed with neuroblastoma who was treated with conventional chemotherapy and developed CMV pneumonia is presented. The patient was treated with intravenous ganciclovir in the pediatric intensive care unit, but died one week later.

Anahtar Kelimeler

-

Kaynakça

  • 1. Taylor GH. Cytomegalovirus. Am Fam Physician 2003;67(3):519-24.
  • 2. Betts RF, Hanshaw JB. Cytomegalovirus (CMV) in the compromised host(s). Annu Rev Med 1977;28:103-10.
  • 3. Rowling AJ, Kvalsvig AJ, Sharples PM, Foot AB, Unsworth DJ. Pneumocystis carinii, cytomegalovirus, and severe transient immunodeficiency. J Clin Pathol 2003;56(9):718-9.
  • 4. Erakgun T, Afrashi F, Nalbantgil S, Ozbaran M, Mentes J. Asymptomatic cytomegalovirus retinitis after cardiac transplantation. Ophthalmologica 2003;217(6):446-50.
  • 5. Schroten H, Manz S, Köhler H, Wolf U, Brockmann M, Riedel F. Fatal desquamative interstitial pneumonia associated with proven CMV infection in an 8- month-old boy. Pediatr Pulmonol 1998;25(5):345-7.
  • 6. Chemaly RF, Torres HA, Hachem RY, Nogueras GM, Aguilera EA, Younes A, et al. Cytomegalovirus pneumonia in patients with lymphoma. Cancer 2005;104(6):1213-20.
  • 7. Akhtar N, Ni J, Langston C, Demmler GJ, Towbin JA. PCR diagnosis of viral pneumonitis from fixed-lung tissue in children. Biochem Mol Med 1996;58(1):66- 76.
  • 8. Vivarelli M, De Ruvo N, Lazzarotto T, Bellusci R, Landini MP, Varani S, et al. Abstension from treatment of low-level pp65 cytomegalovirus antigenemia after liver transplantation: a prospective study. Transplantation 2000;70(8):1183-7.
  • 9. Gentile G, Picardi A, Capobianchi A, Spagnoli A, Cudillo L, Dentamaro T, et al. A prospective study comparing quantitative Cytomegalovirus (CMV) polymerase chain reaction in plasma and pp65 antigenemia assay in monitoring patients after allogeneic stem cell transplantation. BMC Infect Dis 2006;6:167.
  • 10. Spach DH, Bauwens JE, Myerson D, Mustafa MM, Bowden RA. Cytomegalovirus-induced hemorrhagic cystitis following bone marrow transplantation. Clin Infect Dis 1993;16(1):142-4.
  • 11. Bielorai B, Shulman LM, Rechavi G, Toren A. CMV reactivation induced BK virus-associated late onset hemorrhagic cystitis after peripheral blood stem cell transplantation. Bone Marrow Tr a n s p l a n t 2001;28(6):613-4.
  • 12.Biron KK. Antiviral drugs for cytomegalovirus diseases. Antiviral Res 2006;71(2-3):154-63.
  • 13. Nogueira E, Ozaki KS, Tomiyama H, Granato CF, Camara NO, Pacheco-Silva A. The emergence of cytomegalovirus resistance to ganciclovir therapy in kidney transplant recipients. Int Immunopharmacol 2006;6(13-14):2031-7.
  • 14.Bueno J, Ramil C, Green M. Current management strategies for the prevention and treatment of cytomegalovirus infection in pediatric transplant recipients. Paediatr Drugs 2002;4(5):279-90.
  • 15. Machado CM, Dulley FL, Boas LS, Castelli JB, Macedo MC, Silva RL, et al. CMV pneumonia in allogeneic BMT recipients undergoing early treatment of pre-emptive ganciclovir therapy. Bone Marrow Transplant 2000;26(4):413-7.
  • 16. Pérez Mato S, Van Dyke RB. Pulmonary infections in children with HIV infection. Semin Respir Infect 2002;17(1):33-46.

Solid tümörlü bir çocukta sitomegalovirüs pnömonisi

Yıl 2009, Cilt: 24 Sayı: 2, 85 - 87, 01.03.2009

Halil Haldun Emiroğlu Rejin Kebudı Bülent Zülfikar Ömer Görgün Gülden Yılmaz İnci Ayan Nuran Salman Ayper Somer

Öz

Sitomegalovirüs (CMV) enfeksiyonu bağışıklığı baskılanmış hastalarda morbidite ve mortalitenin önemli bir nedenidir. Solid tümör kemoterapisi bağışıklığı baskılayan bir durum olmasına rağmen, sitomegalovirüs hastalığı bildirilmesi sık değildir. CMV enfeksiyonu daha çok yüksek doz tedavi ve transplantasyon geçiren hastalarda bildirilmektedir. Bu yazıda konvansiyonel kemoterapi gören ve sitomegalovirüs pnömonisi gelişen nöroblastom tanılı bir hasta sunulmaktadır. Hasta pediatrik yoğun bakım biriminde intravenöz gansiklovir ile tedavi edildi. Ancak bir hafta sonra hasta kaybedildi.

Anahtar Kelimeler

Ganciclovir pneumonia cytomegalovirus

Kaynakça

  • 1. Taylor GH. Cytomegalovirus. Am Fam Physician 2003;67(3):519-24.
  • 2. Betts RF, Hanshaw JB. Cytomegalovirus (CMV) in the compromised host(s). Annu Rev Med 1977;28:103-10.
  • 3. Rowling AJ, Kvalsvig AJ, Sharples PM, Foot AB, Unsworth DJ. Pneumocystis carinii, cytomegalovirus, and severe transient immunodeficiency. J Clin Pathol 2003;56(9):718-9.
  • 4. Erakgun T, Afrashi F, Nalbantgil S, Ozbaran M, Mentes J. Asymptomatic cytomegalovirus retinitis after cardiac transplantation. Ophthalmologica 2003;217(6):446-50.
  • 5. Schroten H, Manz S, Köhler H, Wolf U, Brockmann M, Riedel F. Fatal desquamative interstitial pneumonia associated with proven CMV infection in an 8- month-old boy. Pediatr Pulmonol 1998;25(5):345-7.
  • 6. Chemaly RF, Torres HA, Hachem RY, Nogueras GM, Aguilera EA, Younes A, et al. Cytomegalovirus pneumonia in patients with lymphoma. Cancer 2005;104(6):1213-20.
  • 7. Akhtar N, Ni J, Langston C, Demmler GJ, Towbin JA. PCR diagnosis of viral pneumonitis from fixed-lung tissue in children. Biochem Mol Med 1996;58(1):66- 76.
  • 8. Vivarelli M, De Ruvo N, Lazzarotto T, Bellusci R, Landini MP, Varani S, et al. Abstension from treatment of low-level pp65 cytomegalovirus antigenemia after liver transplantation: a prospective study. Transplantation 2000;70(8):1183-7.
  • 9. Gentile G, Picardi A, Capobianchi A, Spagnoli A, Cudillo L, Dentamaro T, et al. A prospective study comparing quantitative Cytomegalovirus (CMV) polymerase chain reaction in plasma and pp65 antigenemia assay in monitoring patients after allogeneic stem cell transplantation. BMC Infect Dis 2006;6:167.
  • 10. Spach DH, Bauwens JE, Myerson D, Mustafa MM, Bowden RA. Cytomegalovirus-induced hemorrhagic cystitis following bone marrow transplantation. Clin Infect Dis 1993;16(1):142-4.
  • 11. Bielorai B, Shulman LM, Rechavi G, Toren A. CMV reactivation induced BK virus-associated late onset hemorrhagic cystitis after peripheral blood stem cell transplantation. Bone Marrow Tr a n s p l a n t 2001;28(6):613-4.
  • 12.Biron KK. Antiviral drugs for cytomegalovirus diseases. Antiviral Res 2006;71(2-3):154-63.
  • 13. Nogueira E, Ozaki KS, Tomiyama H, Granato CF, Camara NO, Pacheco-Silva A. The emergence of cytomegalovirus resistance to ganciclovir therapy in kidney transplant recipients. Int Immunopharmacol 2006;6(13-14):2031-7.
  • 14.Bueno J, Ramil C, Green M. Current management strategies for the prevention and treatment of cytomegalovirus infection in pediatric transplant recipients. Paediatr Drugs 2002;4(5):279-90.
  • 15. Machado CM, Dulley FL, Boas LS, Castelli JB, Macedo MC, Silva RL, et al. CMV pneumonia in allogeneic BMT recipients undergoing early treatment of pre-emptive ganciclovir therapy. Bone Marrow Transplant 2000;26(4):413-7.
  • 16. Pérez Mato S, Van Dyke RB. Pulmonary infections in children with HIV infection. Semin Respir Infect 2002;17(1):33-46.
Toplam 16 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Halil Haldun Emiroğlu Bu kişi benim

Rejin Kebudı Bu kişi benim

Bülent Zülfikar Bu kişi benim

Ömer Görgün Bu kişi benim

Gülden Yılmaz Bu kişi benim

İnci Ayan Bu kişi benim

Nuran Salman Bu kişi benim

Ayper Somer Bu kişi benim

Yayımlanma Tarihi 1 Mart 2009
Yayımlandığı Sayı Yıl 2009 Cilt: 24 Sayı: 2

Kaynak Göster

APA Emiroğlu, H. H., Kebudı, R., Zülfikar, B., Görgün, Ö., vd. (2009). Solid tümörlü bir çocukta sitomegalovirüs pnömonisi. Türk Onkoloji Dergisi, 24(2), 85-87.
AMA Emiroğlu HH, Kebudı R, Zülfikar B, Görgün Ö, Yılmaz G, Ayan İ, Salman N, Somer A. Solid tümörlü bir çocukta sitomegalovirüs pnömonisi. Türk Onkoloji Dergisi. Mart 2009;24(2):85-87.
Chicago Emiroğlu, Halil Haldun, Rejin Kebudı, Bülent Zülfikar, Ömer Görgün, Gülden Yılmaz, İnci Ayan, Nuran Salman, ve Ayper Somer. “Solid tümörlü Bir çocukta sitomegalovirüs pnömonisi”. Türk Onkoloji Dergisi 24, sy. 2 (Mart 2009): 85-87.
EndNote Emiroğlu HH, Kebudı R, Zülfikar B, Görgün Ö, Yılmaz G, Ayan İ, Salman N, Somer A (01 Mart 2009) Solid tümörlü bir çocukta sitomegalovirüs pnömonisi. Türk Onkoloji Dergisi 24 2 85–87.
IEEE H. H. Emiroğlu, R. Kebudı, B. Zülfikar, Ö. Görgün, G. Yılmaz, İ. Ayan, N. Salman, ve A. Somer, “Solid tümörlü bir çocukta sitomegalovirüs pnömonisi”, Türk Onkoloji Dergisi, c. 24, sy. 2, ss. 85–87, 2009.
ISNAD Emiroğlu, Halil Haldun vd. “Solid tümörlü Bir çocukta sitomegalovirüs pnömonisi”. Türk Onkoloji Dergisi 24/2 (Mart 2009), 85-87.
JAMA Emiroğlu HH, Kebudı R, Zülfikar B, Görgün Ö, Yılmaz G, Ayan İ, Salman N, Somer A. Solid tümörlü bir çocukta sitomegalovirüs pnömonisi. Türk Onkoloji Dergisi. 2009;24:85–87.
MLA Emiroğlu, Halil Haldun vd. “Solid tümörlü Bir çocukta sitomegalovirüs pnömonisi”. Türk Onkoloji Dergisi, c. 24, sy. 2, 2009, ss. 85-87.
Vancouver Emiroğlu HH, Kebudı R, Zülfikar B, Görgün Ö, Yılmaz G, Ayan İ, Salman N, Somer A. Solid tümörlü bir çocukta sitomegalovirüs pnömonisi. Türk Onkoloji Dergisi. 2009;24(2):85-7.