ANAL KESE BEZİ ADENOKARSİNOMALARININ KANTİTATİF MORFOLOJİ YÖNTEMİ İLE SUBTİPLENDİRİLMESİ

Öz

Bu retrospektif çalışmada, köpeklerde histopatolojik olarak doğrulanmış anal kese bezi adenokarsinomalarının nükleer morfometrik parametreleri sitolojik smear yöntemiyle incelenmiş ve neoplastik subtiple karşılaştırılmıştır. Morfometrik parametreler ve histopatolojik subtip arasındaki korrelasyon, önem derecesi P<0,05 düzeyinde Mann-Whitney U testi (Statistica 6,0, StatSoft, USA) kullanılarak belirlenmiştir. Tubüler, rozet ve kistik anal adenokarsinoma çeşitlerinin çalışılan tüm morfometrik parametreleri arasında istatistiki açıdan önemli farklılıklar bulunmuştur. Bu ön çalışmanın sonucu olarak nükleer morfometri yönteminin köpeklerde görülen anal kese bezi adenokarsinomalarının subtiplendirilmesi amacıyla yardımcı bir yöntem olarak kullanılabileceği söylenebilir.

Anahtar Kelimeler: Sitoloji, görüntü analizi, nükleer morfometri, histopatolojik subtipler, kanin anal kese bezi adenokarsinomaları

Anahtar Kelimeler

• Sitoloji, görüntü analizi, nükleer morfometri, histopatolojik subtipler, kanin anal kese bezi adenokarsinomaları

Subtyping Canine Anal Sac Gland Adenocarcinomas by Means of Quantitative Morphology

Öz

In this retrospective study, nuclear morphometric parameters of histopathologically confirmed anal sac gland adenocarcinomas were investigated on cytological smears in dogs and compared with the neoplastic subtype. The correlation between morphometric parameters and histopathological subtype was determined using Mann-Whitney U test (Statistica 6.0, StatSoft, USA) at level of significance P<0.05. There were statistically significant differences between all studied morphometric parameters of tubular, rosette and solid anal adenocarcinoma patterns. The results of this preliminary study indicated that nuclear morphometry could be used as an auxiliary method for subtyping canine anal sac gland adenocarcinomas.

Key Words: Cytology, image analysis, nuclear morphometry, histopathological subtypes, canine anal sac gland adenocarcinomas

Anahtar Kelimeler

• Cytology, image analysis, nuclear morphometry, histopathological subtypes, canine anal sac gland adenocarcinomas

Kaynakça

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