Methods of Inducting Estrus Cycle in Bitches

Öz

In order to induce the estrus cycle in bitches, exogenous gonadotrophins (LH, FSH, PMSG, hCG), dopamine agonists (bromocryptine, cabergoline) and GnRH agonists (deslorelin) can be used. This review summarizes published reports on induction of estrus cycle in bitches.

Anahtar Kelimeler

• Bitch, estrus, ovulation, induction methods

Köpeklerde Östrus Siklusunu Uyarma Yöntemleri

Öz

Dişi köpeklerde östrusu uyarmak amacıyla, ekzojenik gonadotropinler (Lüteinleştirici Hormon (LH), Follikül Uyarıcı Hormon (FSH), Gebe Kısrak Serum Gonadotropin (PMSG), İnsan Koriyonik Gonadotropin (hCG)), dopamine agonistleri (bromokriptin, kabergolin) ve GnRH agonistleri (deslorelin) kullanılabilmektedir. Bu derlemede, köpeklerde östrus siklusunun uyarılmasında kullanılan yöntemler anlatılmıştır. 

Anahtar Kelimeler

• Dişi köpek, östrus, ovulasyon, uyarılma yöntemleri

Kaynakça

1. Adams, T.E., 2005. Using gonadotropin-releasing hormone (GnRH) and GnRH analogs to modulate testis function and enhance the productivity of domestic animals. Animal Reproduction Science 88, 127-139. E., Arbeiter, K., Barsch, 1988. laufigkeitsinduktion bei der hündin mit einem ergolin- derivat. Journal of Veterinary Medicine A 35, 111-117.
2. Aspden, W.J., Jakson, A., Trigg, T.E., D’Occhio, M.J., 2003. Pituitary expression of LH- and FSH-subunit mRNA, cellular distrubition of LH- subunit mRNA and LH and FSH synthesis during and after treatment with a gonadotropin releasing hormone agonist in heifers. Reproduction Fertility and Development 15, 149-156.
3. Beijerink, N.J., Dieleman, S.J., Kooistra, H.S., Okkens, A.C., 2003. Low doses of bromocriptine shorten the interestrous interval in the bitch without lowering plasma prolactin concentration. Therigenology 60, 1379-1386.
4. Bouchard, G., Youngquist, R.S., Clark, B., Concannon, P.W., Braun, W.F., 1991. Estrus induction in the bitch using a combination Theriogenology 36, 51-65. and FSH-P.
5. Bouchard, G.F., Gross, S., Ganjam, V.K., Youngquist, R.S., Concannon, W.W., Krause, G.F., 1993. Oestrus induction in the bitch with the synthetic oestrogens diethylstilboestrol. Journal of Reproduction and Fertility 47, 515–516.
6. Cain, J.L., Cain, G.R., Feldman, C.E., Lasley, B.L., Stabenfeldt, H.G., 1988. Use of pulzatile intravenous administration of GnRH to induce fertile estrus in bitches. American Journal of Veterinary Research 49, 1993-1996.
7. Chaffaux, D.L., Pontois, M., Deletang, F., Thibier, M., 1984. Induction of ovarian activity in anestrus beagle bitches. British Veterinary Journal 140, 191-195.
8. Chakraborty, P.K, Wildt, D.E., Seager, S.W.J., 1982. Induction of estrus and ovulation in the cat and dog. Veterinary Clinics of North America. Small Animal Practice 12, 85- 92.

9. Chakraborty, P.K., Saeger, J.W., 1986. Estrus and Ovulation Induction in the Bitch In: Thomas, J.B. (Ed.), Small Animal Reproduction and Infertility. Lea and Febiger, Philadelphia, pp. 193-195.
10. Cirit, Ü., Bacınoglu, S., Cangül, I.T., Horoz Kaya, H., Tas, M., Ak, K., 2007. The effects of a low dose of cabergoline on induction of estrus and pregnancy rates in anestrous bitches.Animal Reproduction Science 101, 134-144.
11. Concannon, P.W., 1989. Induction of fertile oestrus in anestrus dogs by constant infusion of GnRH agonist. Journal of Reproduction and Fertility Suppl, 149-160.
12. Concannon, P.W., 1992. Physiology of ovulation fertilization and gestation, and early pregnancy diagnosis in the bitch. In: XVII. WSAVA World Congress World Small Animal Veterinary Assosiation. September, Roma, Italy, 1389-1396.
13. Concannon, P.W., 1993. Biology of gonadotrophin secretion in adult and prepubertal female dogs. Journal of Reproduction and Fertility 49, 3–27.
14. Corrada, Y., Hermo, G., Johnson, C.A., Trigg, T.E., Gobello, C., 2006. Short-term progestin treatments prevent estrous induction by a GnRH agonist implant in anestrous bitches. Theriogenology 65, 366-373.
15. De Gier, J., Kooistra, H.S., Djajadiningrant-Laanen, S.C., Dieleman, S.J., Okkens, A.C., 2006. Differential regulation of the secretion of luteinizing hormone and follicle-stimulating hormone around the time of ovulation in the bitch. Theriogenology 66, 1419–1422.
16. Di Salle, E., Ornati, G., Briatico, G., 1983. FCE 21336 a new ergoline derivate with a potent and long acting lowering effect on prolactin secretion in rats. Journal of Endocrinological Investigation 103, 45.
17. England, G.C.W., Allen, W.E., 1991. Repeatability of events, during spontaneous and gonadotrophins-induced oestrus in bitches. Journal of Reproduction and Fertility 93, 443-448.
18. Fontaine, E., Fontbonne, A., 2010. Use of Deslorelin to control fertility in the bitch. In Symposium Deslorelin: Deslorelin in practice. In: EVSSAR 7th Congress. Louvain la Neuve, Belgium, 15-17.
19. Fontaine, E., Mir, F., Vannier, F., Gérardin, A., Albouy, M., Navarro, C., Fontbonne, A., 2011. Induction of fertile oestrus in the bitch using Deslorelin, a GnRH agonist. Theriogenology 76, 1561-1566.
20. Gobello, C., 2006. Dopamine agonists, anti-progestins, anti- androgens, long-term-release GnRH agonists and anti- estrogens in canine reproduction: A review. Theriogenology 66, 1560-1567.
21. Gobello, C., 2007. New GnRH analogs in canine reproduction. Animal Reproduction Science 100, 1-13.
22. Gobello, C., De la Sota, R.L., Goya, R., 2001. Study of the change of prolactin and progesterone during dopaminergic agonist treatments in pseudopregnant bitches. Animal Reproduction Science 66, 257-267.
23. Günay A., Soylu, M.K., 1996. Anöstrus dönemindeki köpeklerde östrus ve ovulasyonun uyarılması üzerine çalışmalar. Uludağ Üniversitesi Veteriner Fakültesi Dergisi 15, 165-75.
24. Günay, A., Günay, Ü., Soylu, M.K., 2004. Cabergoline applications in early and late anoestrous periods on German shepherd dogs. Revue de Médecine Véterinaire 155, 557-560.
25. Günay, A., Soylu, M.K., 2001. A study of induction of oestrus and ovulation in bitches in anoestrus period. 34 Jahrestagung fortpflazung Gemenischaftstagung. Giessen, Germany, 127. der Humanmedizinische
26. Herbert, C.A., Trigg, T.E., 2005. Applications of GnRH in the control and management of fertility in female animals. Animal Reproduction Science 88, 141-153.
27. Horoz, H., Şenünver, A., Kırşan, I., Ekici, H., Kaşıkçı, G., 1994. Anöstrus köpeklerde östrus ve ovulasyonun uyarılması. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 22, 2.
28. Jeffeoate, I.A., 1993. Endocrinology of anoestrus bitches. Journal of Reproduction and Fertility Suppl 47, 69-76.
29. Jöchle, W., Arbeiter, K., Post, K., Ballabio, R., 1989. Effects on pseudopregnancy, pregnancy and interestrus intervals of pharmacological supression of prolactine secretion in female dogs and cats. Journal of Reproduction and Fertility (Suppl), 39, 199-207.
30. Jöchle, W., Ballabio, R., Di Salle, E., 1987. Inhibition of lactation in the beagle bitch with the prolactine inhibitor cabergoline dose response and aspects of long term safety. Theriogenology 27, 799-810.
31. Kaya, D., Aslan, S., Kaya, S., Kuru, M., Kaçar, C., Schäfer-Somi S., 2013. Clinical and endocrine short-term effects of GnRH analogue deslorelin in prepubertal bitches: Does a “flare-up” occur? Kafkas Üniversitesi Veteriner Fakültesi Dergisi 19, 299-304.
32. Kooistra, H.S., Okkens, A.C., 2001. Secretion of prolactin and growth hormone in relation to ovarian activity in the dog. Reproduction and Domestic Animals 36, 115-129.
33. Kooistra, H.S., Okkens, A.C., Bevers, M.M., Popp-Snijders, C., van Haaften, B., Dieleman, S.J., Schoemaker, J., 1999. Bromocriptine-induced associated with changes in the pulsatile secretion pattern of follicle-stimulating hormone in beagle bitches. Journal of Reproduction and Fertility 117, 387- 393. premature oestrus is
34. Kutzler, M., Wheeler, R., Lamb, S., Volkmann, D., 2002. Deslorelin implant administration beneath the vulvar mucosa for the induction of synchronous estrus in bitches. In: EVSSAR 3rd European Congress, Belgium, 96.
35. Kutzler, M.A., Lamb, S.V., Volkmann, D., 2009. Comparison between vestibular and subcutaneous insertion of deslorelin implants for oestrus induction in bitches. Reproduction and Domestic Animals 44, 83–86.
36. Marshall, J.C., Kelch, P.R., 1986. GnRH Role of pulzatile secretion in the regulation of reproduction. The New England Journal of Medicine 315, 1459-1468.
37. McNeilly, A.S., Crows, A.S., Brookks, J., Evans, G., 1992. Luteinizing hormone pulses, follicle stimulating hormone and the control of follicle selection supplement. Journal of Reproduction and Fertility 45, 5-19.
38. Metallinou, C., Asimakopoulos, B., Schröer, A., Nikolettos, N., 2007. Gonadotropin-releasing hormone in the ovary. Reproduction Science 14, 737-749.
39. Millar, R.P., 2005. GnRHs and GnRH receptors. Animal Reproduction Science 88, 5-28.
40. Moses, DL., Shille, V.M., 1988. Induction of estrus in Greyhound bitches with prolonged idiopathic anestrus or with suppression of estrus after testosteron administration. Journal of the American Veterinary Medical Association 192, 1541-1545.
41. Nakao, T., Aoto, Y., Fukushima, S., Moriyoshi, M., Kawata, K., 1985. Induction of estrus in bitches with exogenous gonadotrophins and pregnancy rate and blood progesterone profiles. Japaneese Journal of Veterinary Science 47, 17-24.
42. Nöthling, O.J., 1994. Luteolisis in the bitches. W.S.A.B.A XIX. World Congress Durbans.
43. Okkens, A.C., Bevers, M.M., Dieleman, S.J., Willemse, A.H., 1990. Evidence for prolactine as the main luteotropic factor in the cyclic dog. Veterinary Quarterly 12, 193- 201.
44. Okkens, A.C., Kooistra, H.S., Dieleman, S.J., Bevers, M.M., 1997. Dopamine agonist effects as opposed to prolactin concentrations in plasma as the influencing factor on the duration of anoestrus in bitches. Journal of Reproduction and Fertility 51, 55-58.
45. Padula, A.M., 2005. GnRH analogues-agonists and antagonists. Animal Reproduction Science 88, 115-26.
46. Page, S.W., 1991. The ethylstilbestrol-clinical pharmacology and alternatives in small animal practice. Australian Veterinary Journal 68, 226-230.
47. Ponglowhapan, S., 2011. Clinical applications of GnRH agonist Deslorelin in dogs and cats. The Thai Journal of Veterinary Medicine 41, 59-63.
48. Prabhaker, S., Sharma, R.D., Dhaliwal, G.S., 1990. Efficacy of hormonal and non-hormonal drugs for induction of oestrus in anoestrus bitches. Indian Veterinary Journal 67, 433-435.
49. Rensis, F. De, Spattini G., Ballabio, R., Scaramuzzi, R.J., 2006. The effect of administering a dopamine agonist (Cabergoline) on follicular and luteal development during pro-estrus and estrus in the female greyhound. Theriogenology 66, 887-895.
50. Renton, J.P., Munro, C.D., Heathcote, R.H., Carmicheal, S., 1981. Some aspects of the aetiology diagnosis and treatment of infertility in the bitch. Journal of Reproduction and Fertility 61, 289-294.
51. Romagnoli, S., Stelletta, C., Milani, C., Gelli, D., Falomo, M.E., Mollo, A., 2009. Clinical use of deslorelin for the control of reproduction in the bitch. Reproduction in Domestic Animals 44, 36-39.
52. Rota, A., Mollo, A., Marinelli, L., Gabai, G., Vincenti, L., 2003. Evaluation of Cabergoline and Buserelin efficacy for oestrus induction in the bitch. Reproduction in Domestic Animals 38, 440-443.
53. Scaramuzzi, R.J., Adams, N.R., Baird, D.T., Campbell, B.K., Downing, J.A., Findlay, J.K., Henderson, K.M., Martin, G.B., McNatty, K.P., McNeilly, A.S., Tsonis C.G., 1993. A model for follicle selection and determination of ovulation rate in the ewe. Reproduction, Fertility and Development 5, 459-478.
54. Schally, A.V., 1999. Luteinizing hormone-releasing hormone analogs: Their impact on the control of tumorigenesis. Peptides 20, 1247-1262.
55. Shille, V.M., Thatcher, M.J., Lloyd, M.L., Miller, D.D., Seyfert, D.F., Sherrod, J.D., 1989. Gonadotrophic control of folliculer development and the use of exogenous gonadotrophins for induction of oestrus and ovulation in the bitch. Journal of Reproduction and Fertility 39, 103-113.
56. Spattini, G., Borghi, V., Thuro´czy, J., Balogh, L., Scaramuzzi, R.J., Rensis, F. De, 2007. Follicular development and plasma concentrations of LH and prolactin in anestrous female dogs treated with the dopamine agonist cabergoline. Theriogenology 68, 826-833.
57. Temple, J.L., Millar, R.P., Rismann, E.F., 2003. An evolutionarily conserved form of gonadotropin– releasing reproductive behaviour. Endocrinology 144, 13-19. energy and
58. Toniollo, G.H., Carlo, R.J., Moreira, E., Ferreira, H.I., Silva, L.A.F., 1985. Effect of treatment with PMSG and HCG on the uterus and ovaries in the bitch. Ars Veterinaria 1, 111-115.
59. Toydemir, T.S.F., Sontaş, B.H., Kılıçarslan, M.R., 2012. New indications of a GnRH agonist deslorelin in small animal reproduction. In: EVSSAR 15th Congress of the European Veterinary Society for Small Animal Reproduction. Whistler, Canada, 26-29.
60. Trigg, T.E., Doyle, A.G., Walsh, J.D., Swangchan-uthai, T., 2006. A review of advances in the use of the GnRH agonist deslorelin in control of reproduction. Theriogenology 66, 1507-1512.
61. Trigg, T.E., Wright, P.J., Armour, A.F., Williamson, P.E., Junaidi, A., Martin, G.B., Doyle, A.G., Walsh, J., 2001. Use of a GnRH analogue implant to produce reversible long-term suppression of reproductive function in male and female domestic dogs. Journal of Reproduction and Fertility (Suppl) 57, 255-261.
62. Vanderlip, S.L., Wing, A.E., Felt, P., Linkie, D., Concannon, P.W., Lasley, B.L., 1987. Ovulation induction in anestrus bitches by pulzatile administration of GnRH. American Association for Laboratory Animal Science 37, 459-464.
63. Verstegen, J., Onclin, K., Silva, L.D.M., Wouters, B.P., Donnay, I., Delehaut, P., Ectors, F., 1993. Induction of abortion in dogs and cats by cabergoline, spesicific anti- prolactine Medecine-Veterinaire 4, 251-258. agonist. Annales-de
64. Verstegen, J.P., Onclin, K., Silva, L.D.M., Concannon, P.W., 1999. Effect of stage of anestrus on the induction of estrus by the dopamine agonist cabergoline in dogs. Theriogenology 51, 597611.
65. Volkmann, D., Kutzler, M., Wheeler, R., Krekeler, N., 2006. The use of deslorelin implants for the synchronization of estrous in diestrous bitches. Theriogenology 66, 1497-501.
66. Von Heimendahl, A., Miller, C., 2012. Clinical evaluation of Deslorelin to induce oestrus, ovulation and pregnancy in the bitch.EVSSAR 15th Congress of the European Veterinary Society for Small Animal Reproduction. Proceedings of the 7th International Symposium on Canine and Feline Reproduction. Whistler, Canada,26- 29.
67. Walter, B., Otzdorff, C., Brugger, N., Braun, J., 2011. Estrus induction in Beagle bitches with the GnRH-agonist implant containing 4.7 mg Deslorelin. Theriogenology 75, 1125-1129.
68. Weilenman, R., Arnold, S., Döbeli, M., Rüsch, P., Zerobin, K., 1993. verabreichung von PMSG und HCG. Schweizer Archiv für Tierheilkunde 135, 236- 241. hündinnen durch
69. Wright, P.J., Verstegen, J.P., Onclin, K., Jöchle, W., Armour, A.F., Martin, G.B., Trigg T.E., 2001. Supression of the oestrus responses of bitches to the GnRH analogue deslorelin by progestin. Journal of Reproduction and Fertility (Suppl) 57, 263-268.
70. Zöldág, L., Fekete, S., Csáky, I., Bersényi, A., 2001. Fertile estrus induced in bitches by bromocryptine, a dopamine agonist: A clinical trial. Theriogenology 55, 1657-1666.