Medikal Ozon ve Veteriner Cerrahide Kullanımı

Yıl 2011, Cilt: 37 Sayı: 2, 177 - 184, 01.11.2011

Özlem Güzel , Esma Yıldar Dilek Erdikmen

Öz

Ozon, oksijenin doğada yüksek enerjili elektrik akımına ve ultraviyole ışınlarına maruz kalması sonucunda oluşan, 3 oksijen atomu taşıyan bir moleküldür. Güçlü bir oksidasyon oluşturma yeteneğine sahiptir. Bu nedenle, bakterisid, virusid ve fungusid olarak etki gösterir.

Ozon sağaltımı, saf oksijen ile ozonun belirli oranlarda (%0,05-5 O₃; %95-99,95 O₂) karıştırılıp, bu karışımın değişik yöntemlerle hastaya uygulanmasını içeren bir sağaltım şeklidir. Ozon, organizmada oksidatif bir etki oluşturarak antioksidan enzim sistemlerini faaliyete geçirir. Lökositler tarafından interferon ve interlökin gibi sitokinlerin salınımını sağlar ve bağışıklık sistemini uyarır.

Ozonun intravenöz, kas içi, transdermal, rektal üfleme ve inhalasyon gibi temel başlıklar altında toplanabilen, 30 farklı uygulama yöntemi bulunmaktadır. Ozon sağaltımı yara iyileşmesi, tümörler, peritonitisler, ortopedik hastalıklar, göz hastalıkları ve diş hekimliği uygulamalarında yer bulabilmektedir.

Sunulan bu derleme ile ozonun sağaltıcı etkilerinin ve uygulama kolaylığının meslektaşlarımızla paylaşılması ve ülkemiz veteriner hekimliği pratiğine yeni bir sağaltım prosedürü olarak sunulabilmesi hedeflenmiştir.

Anahtar Kelimeler: Ozon sağaltımı, otohemoterapi, veteriner cerrahi

Anahtar Kelimeler

Ozon sağaltımı, otohemoterapi, veteriner cerrahi

Kaynakça

• Bette, M., Nusing, R.M., Mutters, R., Zamora, Z.B., Menendez, S., Schulz S., 2006. Efficiency of tazobactam/piperacillin in lethal peritonitis is enhanced after preconditioning of rats with O3/O2-pneumoperitoneum. Shock 25, 23-29.
• Bocci, V., Larini, A., Micheli, V., 2005. Restoration of normoxia by ozone therapy may control neoplastic growth: A review and a working hypothesis. The Journal of Alternative and Complementary Medicine 11 (2), 257-265.
• Bocci, V., 2006a. Scientific and medical aspects of ozone therapy. State of the art. Archives of Medical Research 37, 425-435.
• Bocci, V., 2006b. Is it true that ozone is always toxic? The end of a dogma. Toxicology and Applied Pharmacology 216 (3), 493-504.
• Bocci, V., 2007a. Can ozonetherapy be performed i f the biochemistry of the process cannot be controlled? Archives of Medical Research 38, 584-585.
• Bocci, V., 2007b. The case for oxygen-ozonetherapy. British Journal of Biomedical Science 64(1), 44-49.
• Bocci, V., Borrelli, E . , Travagli, V., Zanardi, I . , 2009. The ozone paradox: ozone is a strong oxidant as well as a medical drug. Medicinal Research Reviews 29 (4), 646-682.
• Calugna, J . L . , Zamora, Z.B., Borrego, A., Rio, S.D., Barber, E . , Menendez, S., Hernandez, F . , Montero, T., Taboada, D., 2005. Ozone
• Medikal Ozon ve Veteriner Cerrahide Kullanımı therapy on rats submitted to subtotal nephrectomy: Role of antioxidant system. Mediators of Inflammation 4, 221-227.
• Clavo, B., Perez, J . L . , Lopez, L . , Suarez, G., Lloret, M., Rodriguez, V., Marias, D., Santana, M., Hernadez, M.A., Martin-Oliva, R., Robaina, F., 2004. Ozone therapy for tumor oxygenation: a pilot study. Evidence-based Complementary and Alternative Medicine 1(1), 93-98.
• Gornicki, A., Gutsze, A., 2000. In vitro effects of ozone on human erythrocyte membranes: An EPR study. Acta Biochimica Polonica 47 (4), 963-971.
• Gundarova, R.A., Khoroshilova-Maslova, I.P., Bordiugova, G.G., Ilatovskaia, L.V., Lapina, I.M., 1996. Experimental validation of using ozonized physiological solutions in intraocular infection. Vestnik Oftalmologii 112 (5), 9-11.
• Hernandez, F.A., 2007. To what extent does ozone therapy need a real biochemical control system? Assessment and importance of oxidative stres. Archives of Medical Research 38, 571-578.
• Kim, H.S., Noh, S.U., Han, Y.W., Kim, K.M., Kang, H., Kim, H.O., Park, Y.M., 2009. Therapeutic effects of topical application of ozone on acute cutaneous wound healing. Journal of Korean Medical Science 24, 368-374.
• Kuz'michev, P.P., Kuz'micheva, N.E., 2004. Use of autohemoozonotherapy in the treatment of nodular thyroid in adolescents. Voprosy Kurortologii Fizioterapii Lechebnoi Fizicheskoi Kultury 1, 24-25.
• L i , L . J . , Yang, Y . G . , Zhang, Z.L., Nie, S.F., L i , Z., L i , F . , Hua, H.Y., Hu, Y . J . , Zhang, H.S., Guo, Y.B., 2007. Protective effects of medical ozone combined with traditional Chinese medicine against chemically-induced hepatic injury in dogs. World Journal Gastroenterology 13 (45), 5989-5994.
• L u , W., L i , Y.H., He, X.F., 2010. Treatment of large lumbar disc herniation with percutaneous ozone injection via the posterior-lateral route and iner magrin of the facet joint. World Journal of Radiology 2 (3), 109-112.
• Madej, P., Plewka, A., Madej, J . , Nowak, M., Plewka, D., 2007. Ozonotherapy in an induced septic shock. I . Effect of ozonotherapy on rat organs in evalutaion of free radical reactions and selected enzymatic systems. Inflamation 30, 52-58.
• Nogales, C., Ferrari, P., Kantarovich, E . , 2008. Ozone therapy in medicine. The Journal of Contemporary Dental Practice 9 (4), 75-84.
• Ohtsuka, H., Ogata, A., Terasaki, N., Koiwa, M., Kawamura, S., 2006. Changes in leukocyte population after ozonated autohemoadministra- tion in cows with inflammatory diseases. Journal of Veterinary Medical Science 68 (2), 175-178.
• Rodriguez, Z.Z., Guanche, D., Alvarez, R . G . , Rosales, F.H., Alonso, Y . , Schulz, S., 2009. Preconditioning with ozone/oxygen mixture induces reversion of some indicators of oxidative stres and prevents organic damage in rats with fecal peritonitis. Journal of Inflammation. Research 58, 371-375.
• Schulz, S., Haussler, U., Mandic, R., Heverhagen, J.T., Neubauer, A., Düne, A.A., Werner, J.A., Weihe, E . , Bette, M., 2008. Treatment with ozone/oxygen-pneumoperitoneum results in complete remission of rabbit squamous cell carcinomas. International Journal of Cancer 122, 2360-2367.
• Shinozuka, Y., Uematsu, K., Takagi, M., Taura, Y., 2008. Comparison of the amounts of endotoxin released from Escherichia coli after exposure to antibiotics and ozone: an In Vitro evaluation. Journal of Veterinary Medical Science 70 (4), 419-422.
• Souza, Y.M., Fontes, B., Martins, J.O., Sannomiya, P., Brito G.S., Younes, R.N., Rasslan, S., 2010. Evaluation of the effects of ozone therapy in the treatment of intra-abdominal infection in rats. Clinics 65 (2), 195-202.
• Stübinger, S., Sader, R., Filippi, A., 2006. The use of ozone in dentistry and maxillofacial surgery . Quintessence International 37 (5), 353-359.
• Travagli, V., Zanardi, I., Valacchi, G., Bocci V., 2010. Ozone and ozonated oils in skin diseases: A review. Mediators of Inflammation, baskıda.
• Tylicki, L . , Biedunkiewicz, B., Rachon, D., 2004. No effects of ozonated autohemotherapy on inflammation response in hemodialyzed patients. Mediators of Inflammation 13, 377ı 380.
• Valacchi, G., Fortino, V., Bocci, V., 2005. The dual action of ozone on the skin. The British Journal Dermatology 153 (6), 1096-1100.
• Valacchi, G., Lim, Y . , Belmonte, G., Miracco, C . , Zanardi, I . , Bocci, V., Travagli, V., 2011. Ozonated sesame oil enhances cutaneous wound healing in SKH1 mice, Wound Repair and Regeneration 19 (1), 107-115.
• Verhein, K . C . , Jacoby, D.B., Fryer, A.D.,2008. IL-1 receptors mediate persistent, but not acut, airway hyperractivity to ozone in Guinea Pigs. American Journal of Repiratory Cell and Molecular Biology 39, 730-738.
• Vigna, I., Menendez-Cepero, S., 2007. Ozone therapy application in different ophthalmologic diseases: study of 59 cases (Aplicación de la ozonoterapia en diferentesenfermedades
• oftalmológicas: estudio de 59 casos). Revista
• Electrónica de Clinica Veterinaria 2 (11), 1-9.