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Morphological Investigations of Experimental Acute Intoxication with the Anticoagulant Rodenticide Bromadiolone in Pheasants

Yıl 2012, Cilt: 38 Sayı: 2, 161 - 173, 15.11.2012

Öz

ABSTRACT

Morphological investigations were performed to observe the changes after experimental acute intoxication with the anticoagulant rodenticide bromadiolone in pheasants. The study was performed with 8 groups of pheasants treated with increasing  doses  of  the  tested  preparation:  5  mg/kg  (group I), 10 mg/kg (group II), 20 mg/kg (group III), 30 mg/kg (group IV), 40 mg/kg (group V), 50 mg/kg (group VI), 60 mg/kg (group VII) and 70 mg/kg (group VIII). All birds from groups I to V have survived the intoxication whereas those from groups VI, VII and VIII have died. During the intoxication, inappetence, accelerated and difficult breathing, adynamia, watery blood discharge from the beak were observed. All pheasants with fatal outcome and the survivors, which were euthanized after the experiment (day 20) were necropsied and gross changes in the liver, the lungs and kidneys were described. Liver alterations varied from strong hyperaemia and activation of the monocytic-macrophageal system to diffuse vacuolar or granular parenchymal dystrophy, as well as necrobiotic to necrotic changes, intra- and inter-lobular haemorrhages, perivascular mononuclear proliferations  and  bile  duct  hyperplasia. Lungs exhibited congestive hyperaemia, oedema in the interstitium and the mucous coats of bronchi and parabronchi, desquamation of epithelial cells in bronchioles and lung parenchymal haemorrhages. In the kidney parenchyma, congestive hyperaemia and haemorrhages were seen, varying within a broad range from karyolysis and karyopyknosis in epithelial tubular cells to cellular desquamation and disintegration and necrosis. All observed changes in parenchymal organs were dose-related, being more pronounced in pheasants treated with higher doses of the tested rodenticide.

Key Words: Anticoagulant rodenticide, bromadiolone, pheasants, acute intoxication, morphological investigations

 

ÖZET

SÜLÜNLERDE ANTİKOAGÜLAN RODENTİSİT BROMADİOLONE İLE OLUŞTURULAN DENEYSEL AKUT İNTOKSİKASYONUN MORFOLOJİK İNCELENMESİ

Sülünlerde antikoagülan rodentisit bromadiolone kullanılarak geliştirilen deneysel akut intoksikasyondan sonra değişimleri gözlemlemek amacıyla morfolojik incelemeler yapılmıştır. Çalışmada 8 grup sülün artan dozlarda incelemeye alındı: 5 mg/kg (Grup 1), 10 mg/kg (Grup 2), 20 mg/kg (Grup 3), 30 mg/kg (Grup 4), 40 mg/kg (Grup 5), 50 mg/kg (Grup 6), 60 mg/kg (Grup 7) ve 70 mg/kg (Grup 8). Birinci ve 5. gruplar arasındaki kuş gruplarının hepsi intoksikasyondan hayatta kalırken; 6., 7. ve 8. grupların öldüğü saptanmıştır. İntoksikasyon sırasında, iştahsızlık, hızlı solunum ve solunum güçlüğü, bitkinlik, gagadan sulu kan geldiği gözlenmiştir. Deney sonucunda (20 gün) ötenazi yapılarak nekropsisi yapılan hayatta kalan sülünlerin ve ölen sülünlerin nekropsilerinde dalak, akciğer ve böbreklerde değişiklikler saptandı. Dalakta şiddetli hiperemi ve monositik-makrofaj sisteminin aktivasyonu sonucu diffuz vakuoler ya da granüler parenkimal distrofi, intra ve inter lobuler hemorajiler, perivasküler mononükleer proliferasyonlar ve safra kanalı hiperplazisi görülmüştür. Akciğerlerde konjestif hiperemi, interstitiyum, bronş ve parabronşların mukoz membranlarında ödem, bronşiollerde bulunan epitel hücrelerde deskuamasyon ve parenkimal hemorajiler görülmüştür. Böbrek parenkiminde, konjestif hiperemi ve hemorajiler görülmüş, epitelyal tubuler hücrelerinde değişen derecelerde karyolizis ve karyopiknozis alanları, hücresel deskuamasyon ve parçalanma ve nekroz odakları görülmüştür. Parenkimal organlarda gözlenen tüm değişiklikler doza bağlı olarak değişmekle birlikte, rodentisitin yüksek dozda uygulandığı sülünlerde değişimler daha belirgin olarak seyretmiştir.

Anahtar Kelimeler: Antikoagülan rodentisit, bromadiolone, sülün, akut intoksikasyon, morfolojik incelemeler

 

Kaynakça

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Toplam 45 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Araştırma Makalesi
Yazarlar

Rumen Bınev Bu kişi benim

İvan Valchev Bu kişi benim

Nely Groseva Bu kişi benim

Lazarin Lazarov Bu kişi benim

Tsanko Hristov Bu kişi benim

Krassimira Uzunova Bu kişi benim

Yayımlanma Tarihi 15 Kasım 2012
Yayımlandığı Sayı Yıl 2012 Cilt: 38 Sayı: 2

Kaynak Göster

APA Bınev, R., Valchev, İ., Groseva, N., Lazarov, L., vd. (2012). Morphological Investigations of Experimental Acute Intoxication with the Anticoagulant Rodenticide Bromadiolone in Pheasants. İstanbul Üniversitesi Veteriner Fakültesi Dergisi, 38(2), 161-173. https://doi.org/10.16988/iuvfd.53779
AMA Bınev R, Valchev İ, Groseva N, Lazarov L, Hristov T, Uzunova K. Morphological Investigations of Experimental Acute Intoxication with the Anticoagulant Rodenticide Bromadiolone in Pheasants. iuvfd. Kasım 2012;38(2):161-173. doi:10.16988/iuvfd.53779
Chicago Bınev, Rumen, İvan Valchev, Nely Groseva, Lazarin Lazarov, Tsanko Hristov, ve Krassimira Uzunova. “Morphological Investigations of Experimental Acute Intoxication With the Anticoagulant Rodenticide Bromadiolone in Pheasants”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 38, sy. 2 (Kasım 2012): 161-73. https://doi.org/10.16988/iuvfd.53779.
EndNote Bınev R, Valchev İ, Groseva N, Lazarov L, Hristov T, Uzunova K (01 Kasım 2012) Morphological Investigations of Experimental Acute Intoxication with the Anticoagulant Rodenticide Bromadiolone in Pheasants. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 38 2 161–173.
IEEE R. Bınev, İ. Valchev, N. Groseva, L. Lazarov, T. Hristov, ve K. Uzunova, “Morphological Investigations of Experimental Acute Intoxication with the Anticoagulant Rodenticide Bromadiolone in Pheasants”, iuvfd, c. 38, sy. 2, ss. 161–173, 2012, doi: 10.16988/iuvfd.53779.
ISNAD Bınev, Rumen vd. “Morphological Investigations of Experimental Acute Intoxication With the Anticoagulant Rodenticide Bromadiolone in Pheasants”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 38/2 (Kasım 2012), 161-173. https://doi.org/10.16988/iuvfd.53779.
JAMA Bınev R, Valchev İ, Groseva N, Lazarov L, Hristov T, Uzunova K. Morphological Investigations of Experimental Acute Intoxication with the Anticoagulant Rodenticide Bromadiolone in Pheasants. iuvfd. 2012;38:161–173.
MLA Bınev, Rumen vd. “Morphological Investigations of Experimental Acute Intoxication With the Anticoagulant Rodenticide Bromadiolone in Pheasants”. İstanbul Üniversitesi Veteriner Fakültesi Dergisi, c. 38, sy. 2, 2012, ss. 161-73, doi:10.16988/iuvfd.53779.
Vancouver Bınev R, Valchev İ, Groseva N, Lazarov L, Hristov T, Uzunova K. Morphological Investigations of Experimental Acute Intoxication with the Anticoagulant Rodenticide Bromadiolone in Pheasants. iuvfd. 2012;38(2):161-73.