YAŞA BAĞLI MAKULA DEJENERASYONUNA SEKONDER KOROİDAL NEOVASKÜLARİZASYONDA İNTRAVİTREAL RANİBİZUMAB TEDAVİSİ SONUÇLARIMIZ

Öz

Yaşa bağlı makula dejenerasyonuna YBMD sekonder koroidal neovaskülarizasyonda KNV intravitreal ranibizumab IVR tedavisinin sonuçlarını değerlendirmek. Bu retrospektif çalışmada daha önce hiç tedavi edilmemiş, YBMD’ye sekonder KNV’u olan ve tekrarlayan IVR enjeksiyonları ile tedavi edimiş olan 67 hastanın 74 gözü değerlendirildi. Hastalara ilk 3 ayda aylık ve daha sonra gerekirse enjeksiyon yapıldı. Her enjeksiyondan sonra 1.gün ve 1.ay, üç enjeksiyon tamamlandıktan sonra aylık olarak muayene edildi. Her muayenede düzeltilmiş en iyi görme keskinliği BCVA ve santral foveolar kalınlık CFT kaydedildi. Üç ayda bir fundus floresein anjiografi FFA uygulandı. Lezyonlar klasik, okkült ve fibrovasküler pigment epitel dekolmanı PED olarak sınıflandırıldı. Hastaların yaş ortalaması 72.7± 9.3 yıl idi. Ortalama izlem süresi 10.6± 5,0 4.0-24.0 ay idi. Klasik KNV’li 22 %29.7 , okkult KNV’li 42 %56.8 ve fibrovasküler PED’i olan 10 %13.5 hasta vardı. Ortalama enjeksiyon sayısı 3.12 idi. Ortalama BCVA 1.08±0.47 logMAR’dan 0.97±0.49 logMAR’a arttı p:0.023 . Ortalama CFT, üçüncü ayda 335.0 µm’den 255.1 µm’e azaldı p

Anahtar Kelimeler

• İntravitreal,ranibizumab,YBMD,koroidal neovaskülarizasyon

THE RESULTS OF INTRAVITREAL RANIBIZUMAB TREATMENT FOR CHOROIDAL NEOVASCULARIZATION SECONDARY TO AGE RELATED MACULAR DEGENERATION

Abstract

To evaluate the efficacy of intravitreal ranibizumab IVR in the treatment of choroidal neovascularization secondary to age related macular degeneration. In this retrospective study 74 eyes of 67 patients with choroidal neovascularization CNV secondary to AMD who had no treatment earlier and treated with repeated Ranibizumab injections, were evaluated. Patients had monthly injections during first three months and repeated injections were given as needed later on. Visits were performed at the first day and four weeks after each injection and monthly after the completion of three injections. Best corrected visual acuity BCVA and central foveolar thickness CFT were noted in each visit. Flourescein angiography was performed quarterly. Lesions were classified as classic, occult or fibrovascular pigment epithelial detachment PED . Mean age was 72.7± 9.3 years. Mean follow-up was 10.6± 5,0 4.0-24.0 months. Lesions were classified as classic CNV in 22 29.7% , occult CNV in 42 56.8% and fibrovascular PED in 10 13.5% eyes. Average injection number was 3.12. Mean BCVA increased significantly from 1.08±0.47 logMAR to 0.97±0.49 logMAR p:0.023 . Mean CFT decreased from 335.0 µm to 255.1 µm at third month p

Keywords

• Intravitreal,ranibizumab,AMD,choroidal neovascularization

Kaynakça

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