Öz
İntraoperatif sentinel lenf nodunun patolojik değerlendirilmesindeki yanlış negatiflik intraoperatif patolojik değerlendirme yöntemiyle negatif fakat postoperatif immünohistokimyasal incelemede pozitif saptanması sonucumuzu görmek ve bu hasta grubuna sonradan yapılan aksiller lenf nodu diseksiyonunda çıkan nonsentinal lenf nodlarının durumunu incelemek istedik. Araştırmamıza Ocak 2003 ve Mayıs 2010 tarihleri arasında Ege Üniversitesi Genel Cerrahi Kliniğinde tanı ve tedavi alan, klinik olarak aksillası negatif olan, erken evre meme kanserli 740 hasta dâhil edildi. Sentinel Lenf Nodu Biopsisi SLNB uygulanan 740 hastanın 18 %2.4 ’inde sentinel lenf nodu intraoperatif yöntemle negatif bulunduğu halde postoperatif immünhistokimya İHK ile pozitif saptanmıştır. 18 hastamızın tümüne aksiller diseksiyon uyguladık. Aksiller diseksiyon sonrası 4 %22 hastada non-sentinel lenf nodu NSLN tutulumu gözlenmiştir
Anahtar Kelimeler
Kaynakça
- ) Kell MR, Burke JP, Barry M, Morrow M. Outcome of axillary staging in early breast cancer: a meta-analysis. Breast Cancer Res Treat 2010
- ) Menes TS, Tartter PI, Mizrachi H, et al. Touch preparation or frozen section for intraoperative detection of sentinel lymph node metastases from breast cancer. Ann Surg Oncol 2003; 10: 1166- 70.
- ) Sauer T, Engh V, Holck AM, et al. lmprint cytology of sentinel lymph nodes in breast cancer. Experience with rapid, intraoperative diagnosis and primary screening by cytotecnologists. Acta Cytol 2003; 47: 768-73. 4)
- İntraoperative examination of sentinel lymph nodes by immunohistochemical staining in patients with breast cancer. Eur J Surg Oncol. 2006;32:405–9.
- J. 5) Weinberg ES, Dickson D, White L.Cytokeratin staining for intraoperative evaluation of sentinel lymph nodes in patients with invasive lobular carcinoma Am J Surg 2004; 188: 419-22.
- ) Moore KH, Yhaler HT, Tan LK, Immunohistochemically detected tumor cells in the sentinel lymph nodes of patients with breast carcinoma: biologic metastasis or procedural artifact. Cancer 2004;100:929–34.
- ) Turner RR, Ollila DW, Stern 5. et al. Optimal histopathologic examination of the sentinel lymph node for breast carcinoma staging. Am J Surg Pathol 1999; 23: 263-7.
- ) Kristine E. Calhoun M.D., Nora M. Hansen M.D., Roderick R. Turner M.D. and
- Nonsentinel node metastases in breast cancer patients with isolated tumor cells in the sentinel node: implications for completion axillary node dissection. Am J Surg 2005; 190: 588-91.
- M.D. 9) Richard J Gray MD, Barbara A Pockaj MD,Cristopher R. Conley MD, Sentinel lymph node metastases detected by immunohistochemistry
- mandate complete axillary lymph node dissection in breast cancer. Annals of Surgical Oncology 2004; 11:1056-1060.
Öz
The aim of this study is to see the intra-operative sentinel lymph node pathologic assessment false negativity index and to evaluate the nonsentinel lymph node status after regular axillary lymph node dissection. Patients with early stages of breast cancer and clinically node-negative axilla admitted to Ege University General Surgery Department between January 2003 and May 2010 were included in this study. Immunohistochemistry evaluation revealed positive node in 18 2.4% out of 740 patient which were reported as node negative on intraoperative pathologic lymph node assessment. ALND is performed in 18 patients. We revealed NSLN involvement in 4 %22 patients after ALND
Anahtar Kelimeler
Kaynakça
- ) Kell MR, Burke JP, Barry M, Morrow M. Outcome of axillary staging in early breast cancer: a meta-analysis. Breast Cancer Res Treat 2010
- ) Menes TS, Tartter PI, Mizrachi H, et al. Touch preparation or frozen section for intraoperative detection of sentinel lymph node metastases from breast cancer. Ann Surg Oncol 2003; 10: 1166- 70.
- ) Sauer T, Engh V, Holck AM, et al. lmprint cytology of sentinel lymph nodes in breast cancer. Experience with rapid, intraoperative diagnosis and primary screening by cytotecnologists. Acta Cytol 2003; 47: 768-73. 4)
- İntraoperative examination of sentinel lymph nodes by immunohistochemical staining in patients with breast cancer. Eur J Surg Oncol. 2006;32:405–9.
- J. 5) Weinberg ES, Dickson D, White L.Cytokeratin staining for intraoperative evaluation of sentinel lymph nodes in patients with invasive lobular carcinoma Am J Surg 2004; 188: 419-22.
- ) Moore KH, Yhaler HT, Tan LK, Immunohistochemically detected tumor cells in the sentinel lymph nodes of patients with breast carcinoma: biologic metastasis or procedural artifact. Cancer 2004;100:929–34.
- ) Turner RR, Ollila DW, Stern 5. et al. Optimal histopathologic examination of the sentinel lymph node for breast carcinoma staging. Am J Surg Pathol 1999; 23: 263-7.
- ) Kristine E. Calhoun M.D., Nora M. Hansen M.D., Roderick R. Turner M.D. and
- Nonsentinel node metastases in breast cancer patients with isolated tumor cells in the sentinel node: implications for completion axillary node dissection. Am J Surg 2005; 190: 588-91.
- M.D. 9) Richard J Gray MD, Barbara A Pockaj MD,Cristopher R. Conley MD, Sentinel lymph node metastases detected by immunohistochemistry
- mandate complete axillary lymph node dissection in breast cancer. Annals of Surgical Oncology 2004; 11:1056-1060.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Research Article |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Eylül 2013 |
| Yayımlandığı Sayı | Yıl 2013 Cilt: 17 Sayı: 3 |