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LARİNGEAL NÖROFİBROM: OLGU SUNUMU

Yıl 2015, Cilt: 19 Sayı: 1, 41 - 45, 01.03.2015

Öz

Laringeal nörofibrom, benign laringeal tümörler arasında çok nadirdir. Sıklıkla, supraglottik ariepiglottik fold yerleşimli, çocuklarda ve nörofibromatozis tip 1 ile ilişkili olarak görülmektedir. Biz soliter laringeal nörofibrom sebebiyle opere edilen 60 yaşındaki erkek olgumuzu oldukça nadir görülmesi nedeniyle paylaştık. Tümörde immunhistokimyasal olarak S100 pozitifliğine ek olarak CD34 ve bcl2 pozitifliği varlığı nörofibrom tanısını destekledi. Larinkste nonepitelyal bir tümör ile karşılaşıldığında nadir olmakla birlikte nörofibrom akla getirilmeli, tanının immunhistokimyasal olarak S100, CD34 ve bcl2 pozitifliği ile desteklenebileceği akılda tutulmalıdır

Kaynakça

  • ) Rebecca AL, David AS, Jane LW, Joshua SS. Diffuse Subglottic Laryngeal Neurofibroma in an Adult. Otolaryngology Head and Neck Surgery 2009;141(4):545-7.
  • ) Chen YW, Fang TJ, Li HY. A Solitary Laryngeal Neurofibroma in A Pediatric Patient. Chang Gung Med J 2004;27(12): 3.
  • ) Liu J, Wong CF, Lim F, Kanagalingam J. Glottic neurofibroma in an elderly patient: a case report. J Voice 2013;27(6):644-6.
  • ) Chinn SB, Collar RM, McHugh JB, Hogikyan ND, neurofibroma: case report and review of the literature. Int J Pediatr Otorhinolaryngol ;78(1):142-7. Pediatric laryngeal ) Gstöttner M, Galvan O, Gschwendtner A, Neher A. Solitary subglottic neurofibroma: a report of an unusual manifestation. Eur Arch Otorhino laryngol 2005;262(9):705-7.
  • ) Hirose T, Tani T, Shimada T, Ishizawa K, Shimada S, Sano T. Immunohistochemical demonstration of EMA/Glut1-positive peri- neurial cells and CD34-positive fibroblastic cells in peripheral nerve sheath tumors. Mod Pathol 2003;16(4):293-8.
  • ) Cunha KS, Caruso AC, Faria PA, Silva LE, Fonseca EC, Geller M, de Moura-Neto RS, Lopes VS. Evaluation of Bcl-2, Bcl-x and cleaved caspase-3 in malignant peripheral nerve sheath tumors and neurofibromas. An Acad Bras Cienc 2013;85(4):1497-511.
  • ) Cihangiroglu M, Yilmaz S, Topsakal C, Gok U, Altinsoy B, Cobanoglu B. Laryngeal neurofibroma associated with neurofibroma tosis type 2. AJNR Am J Neuroradiol 2002; (10):1637-9.
  • ) Izadi F, Arbabi, Ahmadzad-Asl M, Doroudinia A. Endolaryngeal Neurofibroma. Acta Medica Iranica 2008;46(4):345 -8.
  • ) Youseml MD, Oberholtzef JC. Neurofibroma of the Aryepiglottic Fold. AJNR ;12(6):1176-8.
  • ) Son HY, Shim HS, Kim JP, Woo SH. Synchronous plexiform neurofibroma in the arytenoids and neurofibroma parapharynx in a patient with non- neurofibromatosis: a case report. J Med Case Rep. 2013;7:15-6. in the ) Fine SW, McClain SA, Li M.
  • Immunohistochemical staining for calretinin is useful for differentiating schwannomas from neurofibromas. Am J Clin Pathol. 2004;122 (4):552-9.

LARYNGEAL NEUROFIBROMA: CASE REPORT

Yıl 2015, Cilt: 19 Sayı: 1, 41 - 45, 01.03.2015

Öz

Laryngeal neurofibroma are extremely rare among benign laryngeal tumors. Most of these lesions are located in the supraglottis, aryepiglottic fold, in the pediatric population and in association with neurofibromatosis type 1 NF1 . We report a an extremely rare case of an 60-year-old man who operated because of solitary laryngeal neurofibroma. In this tumor, presence of CD34 and bcl2 positivity in addition to the immunohistochemical positivity S100, supported the diagnosis of neurofibroma. Althought it is rarely, when encountering aneurofibromas should be considered and keep in mind that the immunohistochemical S100, CD34 and bcl2 staining help to confirm diagosis of a neurofibroma. nonepithelial tumor in the larynx

Kaynakça

  • ) Rebecca AL, David AS, Jane LW, Joshua SS. Diffuse Subglottic Laryngeal Neurofibroma in an Adult. Otolaryngology Head and Neck Surgery 2009;141(4):545-7.
  • ) Chen YW, Fang TJ, Li HY. A Solitary Laryngeal Neurofibroma in A Pediatric Patient. Chang Gung Med J 2004;27(12): 3.
  • ) Liu J, Wong CF, Lim F, Kanagalingam J. Glottic neurofibroma in an elderly patient: a case report. J Voice 2013;27(6):644-6.
  • ) Chinn SB, Collar RM, McHugh JB, Hogikyan ND, neurofibroma: case report and review of the literature. Int J Pediatr Otorhinolaryngol ;78(1):142-7. Pediatric laryngeal ) Gstöttner M, Galvan O, Gschwendtner A, Neher A. Solitary subglottic neurofibroma: a report of an unusual manifestation. Eur Arch Otorhino laryngol 2005;262(9):705-7.
  • ) Hirose T, Tani T, Shimada T, Ishizawa K, Shimada S, Sano T. Immunohistochemical demonstration of EMA/Glut1-positive peri- neurial cells and CD34-positive fibroblastic cells in peripheral nerve sheath tumors. Mod Pathol 2003;16(4):293-8.
  • ) Cunha KS, Caruso AC, Faria PA, Silva LE, Fonseca EC, Geller M, de Moura-Neto RS, Lopes VS. Evaluation of Bcl-2, Bcl-x and cleaved caspase-3 in malignant peripheral nerve sheath tumors and neurofibromas. An Acad Bras Cienc 2013;85(4):1497-511.
  • ) Cihangiroglu M, Yilmaz S, Topsakal C, Gok U, Altinsoy B, Cobanoglu B. Laryngeal neurofibroma associated with neurofibroma tosis type 2. AJNR Am J Neuroradiol 2002; (10):1637-9.
  • ) Izadi F, Arbabi, Ahmadzad-Asl M, Doroudinia A. Endolaryngeal Neurofibroma. Acta Medica Iranica 2008;46(4):345 -8.
  • ) Youseml MD, Oberholtzef JC. Neurofibroma of the Aryepiglottic Fold. AJNR ;12(6):1176-8.
  • ) Son HY, Shim HS, Kim JP, Woo SH. Synchronous plexiform neurofibroma in the arytenoids and neurofibroma parapharynx in a patient with non- neurofibromatosis: a case report. J Med Case Rep. 2013;7:15-6. in the ) Fine SW, McClain SA, Li M.
  • Immunohistochemical staining for calretinin is useful for differentiating schwannomas from neurofibromas. Am J Clin Pathol. 2004;122 (4):552-9.
Toplam 11 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Research Article
Yazarlar

Enver Vardar Bu kişi benim

Tolgahan Çatlı Bu kişi benim

Tulu Kebat Bu kişi benim

Asuman Argon Bu kişi benim

Çağrı Çelik Bu kişi benim

Didem Ersöz Bu kişi benim

Yayımlanma Tarihi 1 Mart 2015
Yayımlandığı Sayı Yıl 2015 Cilt: 19 Sayı: 1

Kaynak Göster

APA Vardar, E., Çatlı, T., Kebat, T., Argon, A., vd. (2015). LARİNGEAL NÖROFİBROM: OLGU SUNUMU. İzmir Eğitim Ve Araştırma Hastanesi Tıp Dergisi, 19(1), 41-45.
AMA Vardar E, Çatlı T, Kebat T, Argon A, Çelik Ç, Ersöz D. LARİNGEAL NÖROFİBROM: OLGU SUNUMU. İzmir EAH Tıp Der. Mart 2015;19(1):41-45.
Chicago Vardar, Enver, Tolgahan Çatlı, Tulu Kebat, Asuman Argon, Çağrı Çelik, ve Didem Ersöz. “LARİNGEAL NÖROFİBROM: OLGU SUNUMU”. İzmir Eğitim Ve Araştırma Hastanesi Tıp Dergisi 19, sy. 1 (Mart 2015): 41-45.
EndNote Vardar E, Çatlı T, Kebat T, Argon A, Çelik Ç, Ersöz D (01 Mart 2015) LARİNGEAL NÖROFİBROM: OLGU SUNUMU. İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi 19 1 41–45.
IEEE E. Vardar, T. Çatlı, T. Kebat, A. Argon, Ç. Çelik, ve D. Ersöz, “LARİNGEAL NÖROFİBROM: OLGU SUNUMU”, İzmir EAH Tıp Der, c. 19, sy. 1, ss. 41–45, 2015.
ISNAD Vardar, Enver vd. “LARİNGEAL NÖROFİBROM: OLGU SUNUMU”. İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi 19/1 (Mart 2015), 41-45.
JAMA Vardar E, Çatlı T, Kebat T, Argon A, Çelik Ç, Ersöz D. LARİNGEAL NÖROFİBROM: OLGU SUNUMU. İzmir EAH Tıp Der. 2015;19:41–45.
MLA Vardar, Enver vd. “LARİNGEAL NÖROFİBROM: OLGU SUNUMU”. İzmir Eğitim Ve Araştırma Hastanesi Tıp Dergisi, c. 19, sy. 1, 2015, ss. 41-45.
Vancouver Vardar E, Çatlı T, Kebat T, Argon A, Çelik Ç, Ersöz D. LARİNGEAL NÖROFİBROM: OLGU SUNUMU. İzmir EAH Tıp Der. 2015;19(1):41-5.