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TROMBOTİK TROMBOSİTOPENİK PURPURA: DİRENÇLİ İKİ OLGUNUN BİLDİRİMİ VE LİTERATÜRÜN GÖZDEN GEÇİRİLMESİ

Yıl 2015, Cilt: 19 Sayı: 1, 56 - 59, 01.03.2015

Öz

Trombotik trombositopenik purpura TTP nadir görülen bir hematolojik hastalıktır. Ancak, acilen tanı koyulup tedavi edilmezse, ölümcül sonuçları olan bir hematolojik acildir. TTP’in en etkin tedavisi hastaların %80’inden fazlasında kür elde edilebilen plazmaferezdir. Dirençli TTP’si olan hastalarda immunsupresif tedavi kullanılabilir. Rituksimab otoimmun ve malign hastalıklarda kullanılan önemli bir immunmodulator tedavidir. Biz burada, konvensiyonel tedaviye dirençli olan ve rituksimab ile başarıyla tedavi edilen iki hastayı sunduk

Kaynakça

  • ) Crawley JTB, Scully MA. Thrombotic thrombocytopenic purpura: basic pathophysiology and therapeutic strategies. Hematology Am Soc Hematol Educ Program 2013;2013:292–
  • ) Vesely SK, George JN, Lämmle B, Studt J-D, Alberio L, El- Harake MA, et al. ADAMTS13 activity in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: relation to presenting features and clinical outcomes in a prospective cohort of 142 patients. Blood 2003;102(1):60–8.
  • ) Tsai H-M. Pathophysiology of thrombotic thrombocyto penic purpura. Int J Hematol 2010;91(1):1–19.
  • ) Tsai H-M. Is severe deficiency of ADAMTS-13 specific for thrombotic thrombocytopenic purpura? Yes. J Thromb Haemost 2003;1(4):625–31.
  • ) Terrell DR, Williams LA, Vesely SK, Lämmle B, Hovinga JAK, George JN. The incidence of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: all patients, idiopathic patients, and patients with severe ADAMTS-13 deficiency. J Thromb Haemost 2005;3:1432–6.
  • ) Kiss JE. Thrombotic thrombocytopenic purpura: recognition and management. Int J Hematol 2010;91(1):36–
  • )Booth KK, Terrell DR, Vesely SK, George JN. Systemic infections mimicking thrombotic thrombocytopenic purpura. Am J Hematol 2011;86(9):743–51.
  • ) George JN. Evaluation and management of patients with thrombotic thrombocytopenic purpura. J Intensive Care Med ;22(2):82–91. ) Rock GA, Shumak KH, Buskard NA, Blanchette VS, Kelton JG, Nair RC, et al. Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. Canadian Apheresis Study Group. N Engl J Med 1991;325(6):393–7.
  • ) Tsai H-M. Thrombotic thrombocytopenic purpura: a thrombotic disorder caused by ADAMTS13 deficiency. Hematol Oncol Clin North Am 2007;21(4):609–32, v.
  • ) Petryk M, Grossbard ML. Rituximab therapy of B-cell neoplasms. Clin Lymphoma 2000;1(1):186–94; discussion –6.
  • ) Cerny T, Borisch B, Introna M, Johnson P, Rose AL. Mechanism of action of rituximab. Anticancer Drugs 2002;13 Suppl 2:S3–10.
  • ) Boye J, Elter T, Engert A. An overview of the current clinical use of the anti-CD20 monoclonal antibody rituximab. Ann Oncol 2003;14(4):520–35.
  • ) Czuczman MS, Grillo-López AJ, White CA, Saleh M, Gordon L, LoBuglio AF, et al. Treatment of patients with low- grade B-cell lymphoma with the combination of chimeric anti-CD20 monoclonal antibody and CHOP chemotherapy. J Clin Oncol 1999;17(1):268–76.
  • ) Micallef IN, Kirk A, Norton A, Foran JM, Rohatiner AZ, Lister TA. Peripheral T-cell lymphoma following rituximab therapy for B-cell lymphoma. Blood 1999;93(7):2427–8.
  • ) Cobo-Ibáñez T, Loza-Santamaría E, Pego-Reigosa JM, Marqués AO, Rşa-Figueroa I, Fernández-Nebro A, et al. Efficacy and safety of rituximab in the treatment of non-renal systemic lupus erythematosus: A systematic review. Semin Arthritis Rheum 2014;44(2):175-185.
  • ) Wendler J, Burmester GR, Sörensen H, Krause A, Richter C, Tony H-P, et al. Rituximab in patients with rheumatoid arthritis in routine practice (GERINIS): 6-year results from a prospective, multicentre, non-interventional study in 2,484 patients. Arthritis Res Ther 2014;16(2):R80.
  • ) Rock GA, Shumak KH, Buskard NA, Blanchette VS, Kelton JG, Nair RC, et al. Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. Canadian Apheresis Study Group. N Engl J Med 1991;325(6):393–7.
  • ) Ziman A, Mitri M, Klapper E, Pepkowitz SH, Goldfinger D. Combination vincristine and plasma exchange as initial therapy in patients with thrombotic thrombocytopenic purpura: one institution’s experience and review of the literature. Transfusion 2005;45(1):41–9.
  • ) George JN. Corticosteroids and rituximab as adjunctive treatments for thrombotic thrombocytopenic purpura. Am J Hematol 2012;87 Suppl 1:S88–91.
  • ) Chai W, Chaudhry A, Rabinowitz AP. Successful management of thrombotic thrombocytopenic purpura in a Jehovah’s Witness without plasma exchange. J Clin Apher ;doi:10.1002/jca.21325.
  • ) Theodoropoulos G, Arampatzi S, Diamantidis M, Perifanis V, Diza E, Kaiafa G. Successful treatment with Rituximab in a patient with life-threatening resistant Thrombotic Thrombopenic Purpura. Hippokratia 2012;168(4):388.
  • ) Reddy PS, Deauna-Limayo D, Cook JD, Ganguly SS, Blecke C, Bodensteiner DC, et al. Rituximab in the treatment of relapsed thrombotic thrombocytopenic purpura. Ann Hematol 2005;84(4):232–5.
  • ) Ahmad A, Aggarwal A, Sharma D, Dave HP, Kinsella V, Rick ME, et al. Rituximab for treatment of refractory/relapsing thrombotic thrombocytopenic purpura (TTP). Am J Hematol 2004;77(2):171–6.
  • ) Heidel F, Lipka DB, von Auer C, Huber C, Scharrer I, Hess G. Addition of rituximab to standard therapy improves response rate and progression-free survival in relapsed or refractory thrombotic thrombocytopenic purpura and autoimmune haemolytic anaemia. Thromb Haemost ;97(2):228–33. ) Cataland SR, Jin M, Lin S, Kraut EH, George JN, Wu HM. Effect of prophylactic cyclosporine therapy on ADAMTS13 biomarkers in patients with idiopathic thrombotic thrombocytopenic purpura. Am J Hematol 2008;83(12):911–
  • ) Nosari A, Bernuzzi P, Corneo R, Pungolino E, Muti G, Rossi V, et al. Late response to cyclosporine in refractory thrombotic thrombocytopenic purpura. Int J Hematol ;76(3):284–6. ) Honda K, Hidaka S, Kobayashi S. Successful treatment with cyclosporine of thrombotic thrombocytopenic purpura refractory to corticosteroids and plasma exchange. Ther Apher Dial 2011;15(2):215–7.

THROMBOTIC THROMBOCYTOPENIC PURPURA: A REPORT OF TWO RESISTANCE CASES AND REVIEW OF THE LITERATURE

Yıl 2015, Cilt: 19 Sayı: 1, 56 - 59, 01.03.2015

Öz

Thrombotic thrombocytopenic purpura TTP is a rare hematological disease, but it is a hematological emergency with fatal consequences if not promptly diagnosed and appropriately treated. Plasmapheresis is the most effective therapy of TTP through which more than 80% of patients have been cured. Immunosuppressive therapy is used for patients who have resistance TTP. Rituximab is an important immune modulator therapy in certain autoimmune and malignant disorders. Herein, we report two patients with resistance TTP to conventional therapy who were successfully treated by rituximab. Using rituximab as part of the standard therapy may be more effective to prevent potential mortality and morbidity of TTP than standard approach

Kaynakça

  • ) Crawley JTB, Scully MA. Thrombotic thrombocytopenic purpura: basic pathophysiology and therapeutic strategies. Hematology Am Soc Hematol Educ Program 2013;2013:292–
  • ) Vesely SK, George JN, Lämmle B, Studt J-D, Alberio L, El- Harake MA, et al. ADAMTS13 activity in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: relation to presenting features and clinical outcomes in a prospective cohort of 142 patients. Blood 2003;102(1):60–8.
  • ) Tsai H-M. Pathophysiology of thrombotic thrombocyto penic purpura. Int J Hematol 2010;91(1):1–19.
  • ) Tsai H-M. Is severe deficiency of ADAMTS-13 specific for thrombotic thrombocytopenic purpura? Yes. J Thromb Haemost 2003;1(4):625–31.
  • ) Terrell DR, Williams LA, Vesely SK, Lämmle B, Hovinga JAK, George JN. The incidence of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: all patients, idiopathic patients, and patients with severe ADAMTS-13 deficiency. J Thromb Haemost 2005;3:1432–6.
  • ) Kiss JE. Thrombotic thrombocytopenic purpura: recognition and management. Int J Hematol 2010;91(1):36–
  • )Booth KK, Terrell DR, Vesely SK, George JN. Systemic infections mimicking thrombotic thrombocytopenic purpura. Am J Hematol 2011;86(9):743–51.
  • ) George JN. Evaluation and management of patients with thrombotic thrombocytopenic purpura. J Intensive Care Med ;22(2):82–91. ) Rock GA, Shumak KH, Buskard NA, Blanchette VS, Kelton JG, Nair RC, et al. Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. Canadian Apheresis Study Group. N Engl J Med 1991;325(6):393–7.
  • ) Tsai H-M. Thrombotic thrombocytopenic purpura: a thrombotic disorder caused by ADAMTS13 deficiency. Hematol Oncol Clin North Am 2007;21(4):609–32, v.
  • ) Petryk M, Grossbard ML. Rituximab therapy of B-cell neoplasms. Clin Lymphoma 2000;1(1):186–94; discussion –6.
  • ) Cerny T, Borisch B, Introna M, Johnson P, Rose AL. Mechanism of action of rituximab. Anticancer Drugs 2002;13 Suppl 2:S3–10.
  • ) Boye J, Elter T, Engert A. An overview of the current clinical use of the anti-CD20 monoclonal antibody rituximab. Ann Oncol 2003;14(4):520–35.
  • ) Czuczman MS, Grillo-López AJ, White CA, Saleh M, Gordon L, LoBuglio AF, et al. Treatment of patients with low- grade B-cell lymphoma with the combination of chimeric anti-CD20 monoclonal antibody and CHOP chemotherapy. J Clin Oncol 1999;17(1):268–76.
  • ) Micallef IN, Kirk A, Norton A, Foran JM, Rohatiner AZ, Lister TA. Peripheral T-cell lymphoma following rituximab therapy for B-cell lymphoma. Blood 1999;93(7):2427–8.
  • ) Cobo-Ibáñez T, Loza-Santamaría E, Pego-Reigosa JM, Marqués AO, Rşa-Figueroa I, Fernández-Nebro A, et al. Efficacy and safety of rituximab in the treatment of non-renal systemic lupus erythematosus: A systematic review. Semin Arthritis Rheum 2014;44(2):175-185.
  • ) Wendler J, Burmester GR, Sörensen H, Krause A, Richter C, Tony H-P, et al. Rituximab in patients with rheumatoid arthritis in routine practice (GERINIS): 6-year results from a prospective, multicentre, non-interventional study in 2,484 patients. Arthritis Res Ther 2014;16(2):R80.
  • ) Rock GA, Shumak KH, Buskard NA, Blanchette VS, Kelton JG, Nair RC, et al. Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. Canadian Apheresis Study Group. N Engl J Med 1991;325(6):393–7.
  • ) Ziman A, Mitri M, Klapper E, Pepkowitz SH, Goldfinger D. Combination vincristine and plasma exchange as initial therapy in patients with thrombotic thrombocytopenic purpura: one institution’s experience and review of the literature. Transfusion 2005;45(1):41–9.
  • ) George JN. Corticosteroids and rituximab as adjunctive treatments for thrombotic thrombocytopenic purpura. Am J Hematol 2012;87 Suppl 1:S88–91.
  • ) Chai W, Chaudhry A, Rabinowitz AP. Successful management of thrombotic thrombocytopenic purpura in a Jehovah’s Witness without plasma exchange. J Clin Apher ;doi:10.1002/jca.21325.
  • ) Theodoropoulos G, Arampatzi S, Diamantidis M, Perifanis V, Diza E, Kaiafa G. Successful treatment with Rituximab in a patient with life-threatening resistant Thrombotic Thrombopenic Purpura. Hippokratia 2012;168(4):388.
  • ) Reddy PS, Deauna-Limayo D, Cook JD, Ganguly SS, Blecke C, Bodensteiner DC, et al. Rituximab in the treatment of relapsed thrombotic thrombocytopenic purpura. Ann Hematol 2005;84(4):232–5.
  • ) Ahmad A, Aggarwal A, Sharma D, Dave HP, Kinsella V, Rick ME, et al. Rituximab for treatment of refractory/relapsing thrombotic thrombocytopenic purpura (TTP). Am J Hematol 2004;77(2):171–6.
  • ) Heidel F, Lipka DB, von Auer C, Huber C, Scharrer I, Hess G. Addition of rituximab to standard therapy improves response rate and progression-free survival in relapsed or refractory thrombotic thrombocytopenic purpura and autoimmune haemolytic anaemia. Thromb Haemost ;97(2):228–33. ) Cataland SR, Jin M, Lin S, Kraut EH, George JN, Wu HM. Effect of prophylactic cyclosporine therapy on ADAMTS13 biomarkers in patients with idiopathic thrombotic thrombocytopenic purpura. Am J Hematol 2008;83(12):911–
  • ) Nosari A, Bernuzzi P, Corneo R, Pungolino E, Muti G, Rossi V, et al. Late response to cyclosporine in refractory thrombotic thrombocytopenic purpura. Int J Hematol ;76(3):284–6. ) Honda K, Hidaka S, Kobayashi S. Successful treatment with cyclosporine of thrombotic thrombocytopenic purpura refractory to corticosteroids and plasma exchange. Ther Apher Dial 2011;15(2):215–7.
Toplam 25 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Research Article
Yazarlar

Mehmet Calan Bu kişi benim

Ferda Bilgir Bu kişi benim

Gulsum Cagliyan Bu kişi benim

Can Ozlu Bu kişi benim

Arif Yüksel Bu kişi benim

Oktay Bilgir Bu kişi benim

Yayımlanma Tarihi 1 Mart 2015
Yayımlandığı Sayı Yıl 2015 Cilt: 19 Sayı: 1

Kaynak Göster

APA Calan, M., Bilgir, F., Cagliyan, G., Ozlu, C., vd. (2015). THROMBOTIC THROMBOCYTOPENIC PURPURA: A REPORT OF TWO RESISTANCE CASES AND REVIEW OF THE LITERATURE. İzmir Eğitim Ve Araştırma Hastanesi Tıp Dergisi, 19(1), 56-59. https://doi.org/10.1002/jca.21325.
AMA Calan M, Bilgir F, Cagliyan G, Ozlu C, Yüksel A, Bilgir O. THROMBOTIC THROMBOCYTOPENIC PURPURA: A REPORT OF TWO RESISTANCE CASES AND REVIEW OF THE LITERATURE. İzmir EAH Tıp Der. Mart 2015;19(1):56-59. doi:10.1002/jca.21325.
Chicago Calan, Mehmet, Ferda Bilgir, Gulsum Cagliyan, Can Ozlu, Arif Yüksel, ve Oktay Bilgir. “THROMBOTIC THROMBOCYTOPENIC PURPURA: A REPORT OF TWO RESISTANCE CASES AND REVIEW OF THE LITERATURE”. İzmir Eğitim Ve Araştırma Hastanesi Tıp Dergisi 19, sy. 1 (Mart 2015): 56-59. https://doi.org/10.1002/jca.21325.
EndNote Calan M, Bilgir F, Cagliyan G, Ozlu C, Yüksel A, Bilgir O (01 Mart 2015) THROMBOTIC THROMBOCYTOPENIC PURPURA: A REPORT OF TWO RESISTANCE CASES AND REVIEW OF THE LITERATURE. İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi 19 1 56–59.
IEEE M. Calan, F. Bilgir, G. Cagliyan, C. Ozlu, A. Yüksel, ve O. Bilgir, “THROMBOTIC THROMBOCYTOPENIC PURPURA: A REPORT OF TWO RESISTANCE CASES AND REVIEW OF THE LITERATURE”, İzmir EAH Tıp Der, c. 19, sy. 1, ss. 56–59, 2015, doi: 10.1002/jca.21325.
ISNAD Calan, Mehmet vd. “THROMBOTIC THROMBOCYTOPENIC PURPURA: A REPORT OF TWO RESISTANCE CASES AND REVIEW OF THE LITERATURE”. İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi 19/1 (Mart 2015), 56-59. https://doi.org/10.1002/jca.21325.
JAMA Calan M, Bilgir F, Cagliyan G, Ozlu C, Yüksel A, Bilgir O. THROMBOTIC THROMBOCYTOPENIC PURPURA: A REPORT OF TWO RESISTANCE CASES AND REVIEW OF THE LITERATURE. İzmir EAH Tıp Der. 2015;19:56–59.
MLA Calan, Mehmet vd. “THROMBOTIC THROMBOCYTOPENIC PURPURA: A REPORT OF TWO RESISTANCE CASES AND REVIEW OF THE LITERATURE”. İzmir Eğitim Ve Araştırma Hastanesi Tıp Dergisi, c. 19, sy. 1, 2015, ss. 56-59, doi:10.1002/jca.21325.
Vancouver Calan M, Bilgir F, Cagliyan G, Ozlu C, Yüksel A, Bilgir O. THROMBOTIC THROMBOCYTOPENIC PURPURA: A REPORT OF TWO RESISTANCE CASES AND REVIEW OF THE LITERATURE. İzmir EAH Tıp Der. 2015;19(1):56-9.