Immunotherapeutic Evaluation of Cancer Vaccines

Öz

Tumor vaccines which are among the methods of immunotherapy have an important place against other treatment methods in the fight with cancer. The aim of immunotherapy is to allow the cells of the immune system to destroy cancer cells by targeting them. For this reason,  commonly used immunotherapy methods include monoclonal antibodies, and in particular cancer vaccines. In comparison to other methods, cancer vaccines are more specific that activate T lymphocytes of patients and tries to strengthen the defense of the organism against cancer cells. For this reason, unlike other methods in the fight against cancer, cancer vaccination has been used as a more specific treatment. Many new and effective cancer vaccines are likely to arise with the advancement of studies. There are vaccines currently in progress between phase II and III, which are pending approval from the Food and Drug Administration (FDA). The progress of research on cancer vaccines and the availability of new FDA-approved vaccines has been a source of hope for cancer patients.

Anahtar Kelimeler

• Immunotherapy,cancer vaccine,monoclonal antibody

Kanser Aşılarının İmmünoterapötik Açıdan Değerlendirilmesi

Öz

İmmünoterapi yöntemleri arasında yer alan tümör aşıları, kanserle savaşta diğer tedavi yöntemlerine karşı önemli bir yere sahiptir. İmmünoterapinin amacı, immün sisteme ait hücrelerin kanser hücrelerini hedef alarak onları yok etmelerini sağlamaktır. Bu sebeple en çok kullanılan immünoterapi yöntemlerinin arasında monoklonal antikorlar ve özellikle de kanser aşıları yer almaktadır. Kanser aşıları çok daha spesifik bir yöntem olup hastaların T lenfosit hücrelerini aktive eder ve tümör hücrelerine karşı organizmanın savunmasını güçlendirmeye çalışır. Bu sebeple, kanserle savaşta diğer yöntemlerin aksine daha özgün bir tedavi olarak kullanılmaya başlanmıştır. Yapılan çalışmaların ileriye taşınmasıyla birçok yeni ve etkili kanser aşılarının ortaya çıkması muhtemeldir. Hali hazırda devam eden ve FDA’dan (Food and Drug Administration)  onay almayı bekleyen faz II ve III çalışmaları arasında yer alan aşılar bulunmaktadır. Kanser aşılarıyla yapılan araştırmaların ilerlemesi ve FDA onaylı yeni aşıların bulunması kanser hastaları için yeniden bir umut kaynağı olmuştur. 

Anahtar Kelimeler

• İmmünoterapi,kanser aşısı,monoklonal antikor

Kaynakça

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