BibTex RIS Kaynak Göster
Yıl 2007, Cilt: 1 Sayı: 3, 97 - 106, 01.11.2007

Öz

Light and Electron Microscopic Examinations in the Hippocampus of the Rat Brain Following PTZ-Induced Epileptic Seizures

Yıl 2007, Cilt: 1 Sayı: 3, 97 - 106, 01.11.2007

Öz

The aim of this work was to evaluate hippocampal neurons in the rat brain after single and repetetive seizures induced by pentyleneterazol (PTZ) administration at light- and electron-microscopically. Acute- and chronic-PTZ groups of male Wistar albino rats were given PTZ intraperitoneal injection (i.p.), and the age-matched rats in control group were injected with normal saline. We determined contributions of apoptosis and necrosis to neuronal damage in Nissl-stained- and ultrathin-sections. Necrotic neurons were observed in PTZ-treated groups, especially in the chronic-PTZ group. Histological changes were perikaryal swelling, chromatolysis and decreasing of Nissl in the necrotic neurons. Necrotic and apoptotic neurons of the hippocampus were observed ultrastructurally in the PTZ groups. These findings demonstrated a significant decrease in the number of hippocampal neurons in the chronic-PTZ group. It is clear that in the hippocampal regions repeated PTZ-induced seizures of the rats cause neuronal damage and neuronal loss

Toplam 0 adet kaynakça vardır.

Ayrıntılar

Diğer ID JA93UE84ST
Bölüm Araştırma Makalesi
Yazarlar

Melda Yardımoglu Bu kişi benim

Gul Ilbay Bu kişi benim

Sibel Kokturk Bu kişi benim

Funda Durmaz Onar Bu kişi benim

Deniz Sahın Bu kişi benim

Faruk Alkan Bu kişi benim

Hakki Dalcık Bu kişi benim

Yayımlanma Tarihi 1 Kasım 2007
Yayımlandığı Sayı Yıl 2007 Cilt: 1 Sayı: 3

Kaynak Göster

APA Yardımoglu, M., Ilbay, G., Kokturk, S., Onar, F. D., vd. (2007). Light and Electron Microscopic Examinations in the Hippocampus of the Rat Brain Following PTZ-Induced Epileptic Seizures. Journal of Applied Biological Sciences, 1(3), 97-106.
AMA Yardımoglu M, Ilbay G, Kokturk S, Onar FD, Sahın D, Alkan F, Dalcık H. Light and Electron Microscopic Examinations in the Hippocampus of the Rat Brain Following PTZ-Induced Epileptic Seizures. J.appl.biol.sci. Kasım 2007;1(3):97-106.
Chicago Yardımoglu, Melda, Gul Ilbay, Sibel Kokturk, Funda Durmaz Onar, Deniz Sahın, Faruk Alkan, ve Hakki Dalcık. “Light and Electron Microscopic Examinations in the Hippocampus of the Rat Brain Following PTZ-Induced Epileptic Seizures”. Journal of Applied Biological Sciences 1, sy. 3 (Kasım 2007): 97-106.
EndNote Yardımoglu M, Ilbay G, Kokturk S, Onar FD, Sahın D, Alkan F, Dalcık H (01 Kasım 2007) Light and Electron Microscopic Examinations in the Hippocampus of the Rat Brain Following PTZ-Induced Epileptic Seizures. Journal of Applied Biological Sciences 1 3 97–106.
IEEE M. Yardımoglu, “Light and Electron Microscopic Examinations in the Hippocampus of the Rat Brain Following PTZ-Induced Epileptic Seizures”, J.appl.biol.sci., c. 1, sy. 3, ss. 97–106, 2007.
ISNAD Yardımoglu, Melda vd. “Light and Electron Microscopic Examinations in the Hippocampus of the Rat Brain Following PTZ-Induced Epileptic Seizures”. Journal of Applied Biological Sciences 1/3 (Kasım 2007), 97-106.
JAMA Yardımoglu M, Ilbay G, Kokturk S, Onar FD, Sahın D, Alkan F, Dalcık H. Light and Electron Microscopic Examinations in the Hippocampus of the Rat Brain Following PTZ-Induced Epileptic Seizures. J.appl.biol.sci. 2007;1:97–106.
MLA Yardımoglu, Melda vd. “Light and Electron Microscopic Examinations in the Hippocampus of the Rat Brain Following PTZ-Induced Epileptic Seizures”. Journal of Applied Biological Sciences, c. 1, sy. 3, 2007, ss. 97-106.
Vancouver Yardımoglu M, Ilbay G, Kokturk S, Onar FD, Sahın D, Alkan F, Dalcık H. Light and Electron Microscopic Examinations in the Hippocampus of the Rat Brain Following PTZ-Induced Epileptic Seizures. J.appl.biol.sci. 2007;1(3):97-106.