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Association of HLA- B7, B8, B27 and B51 with Genetic Protection Against Hepatitis B Virus

Yıl 2009, Cilt: 3 Sayı: 2, 59 - 61, 01.07.2009

Mohammad Najafızadeh Naser Farhadı Bahador Sarkarı

Öz

It is generally believed that viral clearance or chronic infection following hepatitis B virus (HBV) infection is linked to the genetic background of the host and human leukocyte antigens (HLA) play a central role. This study was conducted to determine associations between some of HLA classI genes with the outcome of hepatitis B infection. Subjects of this study were 64 individuals who were assigned into two group, case and con trol, based on their clinical and ser ologic profiles. Case gr oup were 27 p atients infected with HBV and controls were 37 subjects with HBV natural convalescent who recovered from a HBV in fection. Ty ping of HLA cla ss I was performed b y serol ogic method. No significant difference was f ound between mean age of co ntrol and patie nt group while th e differ ence in sex of two groups was significant (P<0.05). The most fr equent detected HLA antigens were B51 (40, 1%), B27 (14 .1%), B8 (12 .5%) and B7 (10.9%). Significant association was found between HBV p ersistence and HLA-B27. HLA-B 27 was associated with an increase in HB Vpersistence. The findings su pport the id ea that polymorphism of HLA class I may influence th e chronicity of HBV infection

Anahtar Kelimeler

HLA Hepatitis B HBV persistence

Yıl 2009, Cilt: 3 Sayı: 2, 59 - 61, 01.07.2009

Mohammad Najafızadeh Naser Farhadı Bahador Sarkarı

Öz

Toplam 0 adet kaynakça vardır.

Ayrıntılar

Diğer ID JA59DY53DM
Bölüm Araştırma Makalesi
Yazarlar

Mohammad Najafızadeh Bu kişi benim

Naser Farhadı Bu kişi benim

Bahador Sarkarı Bu kişi benim

Yayımlanma Tarihi 1 Temmuz 2009
Yayımlandığı Sayı Yıl 2009 Cilt: 3 Sayı: 2

Kaynak Göster

APA Najafızadeh, M., Farhadı, N., & Sarkarı, B. (2009). Association of HLA- B7, B8, B27 and B51 with Genetic Protection Against Hepatitis B Virus. Journal of Applied Biological Sciences, 3(2), 59-61.
AMA Najafızadeh M, Farhadı N, Sarkarı B. Association of HLA- B7, B8, B27 and B51 with Genetic Protection Against Hepatitis B Virus. J.appl.biol.sci. Temmuz 2009;3(2):59-61.
Chicago Najafızadeh, Mohammad, Naser Farhadı, ve Bahador Sarkarı. “Association of HLA- B7, B8, B27 and B51 With Genetic Protection Against Hepatitis B Virus”. Journal of Applied Biological Sciences 3, sy. 2 (Temmuz 2009): 59-61.
EndNote Najafızadeh M, Farhadı N, Sarkarı B (01 Temmuz 2009) Association of HLA- B7, B8, B27 and B51 with Genetic Protection Against Hepatitis B Virus. Journal of Applied Biological Sciences 3 2 59–61.
IEEE M. Najafızadeh, N. Farhadı, ve B. Sarkarı, “Association of HLA- B7, B8, B27 and B51 with Genetic Protection Against Hepatitis B Virus”, J.appl.biol.sci., c. 3, sy. 2, ss. 59–61, 2009.
ISNAD Najafızadeh, Mohammad vd. “Association of HLA- B7, B8, B27 and B51 With Genetic Protection Against Hepatitis B Virus”. Journal of Applied Biological Sciences 3/2 (Temmuz 2009), 59-61.
JAMA Najafızadeh M, Farhadı N, Sarkarı B. Association of HLA- B7, B8, B27 and B51 with Genetic Protection Against Hepatitis B Virus. J.appl.biol.sci. 2009;3:59–61.
MLA Najafızadeh, Mohammad vd. “Association of HLA- B7, B8, B27 and B51 With Genetic Protection Against Hepatitis B Virus”. Journal of Applied Biological Sciences, c. 3, sy. 2, 2009, ss. 59-61.
Vancouver Najafızadeh M, Farhadı N, Sarkarı B. Association of HLA- B7, B8, B27 and B51 with Genetic Protection Against Hepatitis B Virus. J.appl.biol.sci. 2009;3(2):59-61.