Public health risk assessments associated with heavy metal levels in panga fish fillets imported from Vietnam

Year 2022, Volume: 6 Issue: 4, 568 - 578, 30.12.2022

Serdar Kilercioğlu , Ali Rıza Koşker , Ece Evliyaoğlu

https://doi.org/10.31015/jaefs.2022.4.9

Cited By: 2

Abstract

Pangasius hypophthalmus (panga fish) is farmed in the Mekong River (Vietnam), which is known as a polluted river, and exported to many countries. The present study aimed to determine heavy metal levels in frozen panga fillets imported from Vietnam as well as the risks of heavy metals to human health. Panga fillets belonging to four brands were bought from three supermarkets in Adana city, Turkey, and heavy metals (As, Cd, Hg, Pb, Ni, Cu, Mn and Co) were analyzed. To analyze the potential risks to human health, EWI (estimated weekly intake), THQ (target hazard quotient), and CR (lifetime cancer risk) values were calculated to assess the potential risks to consumer health of the metal content in panga fillets. The health risk assessment values were calculated for children and adults according to the frequency of consumption once, three and seven times a week. The results revealed that the presence of heavy metals in the studied panga fillets was below permissible limits indicated by WHO (World Health Organization), EPA (United States Environmental Protection Agency) and TKB (Turkish Fisheries Laws and Regulations). The EWI, THQ or ∑ THQ and CR values were below PTWI (provisional tolerable weekly intake), 1 and 10-5, respectively. Remarkably, the highest values of the EWI/PTWI ratio and THQs were found for children.

Keywords

Metal toxicity , Pangasius hypophthalmus , consumer health risks , cancer risks

References

• Agah, H., Leermakers, M., Elskens, M., Fatemi, S. M. R. & Baeyens, W. (2009). Accumulation of trace metals in the muscle and liver tissues of five fish species from the Persian Gulf. Environmental Monitoring and Assessment, 157(1–4), 499–514. DOI:10.1007/s10661-008-0551-8
• Alibabić, V., Vahčić, N. & Bajramović, M. (2007). Bioaccumulation of Metals in Fish of Salmonidae Family and the Impact on Fish Meat Quality. Environmental Monitoring and Assessment, 131(1–3), 349–364. DOI:10.1007/s10661-006-9480-6
• Andaloro, F., Romeo, T., Renzi, M., Guerranti, C., Perra, G., Consoli, P., Perzia, P. & Focardi, S. E. (2012). Alteration of potential harmful elements levels in sediments and biota from the central Mediterranean Sea (Aeolian Archipelago) following an episode of intense volcanic activity. Environmental Monitoring and Assessment, 184(7), 4035–4047. DOI: 10.1007/s10661-011-2242-0
• Árvay, J., Tomáš, J., Hauptvogl, M., Massányi, P., Harangozo, Ľ., Tóth, T., Stanovic, R., Bryndzova, S. & Bumbalová, M. (2015). Human exposure to heavy metals and possible public health risks via consumption of wild edible mushrooms from Slovak Paradise National Park, Slovakia. Journal of Environmental Science and Health, Part B, 50(11), 833-843.
• Authman, M. M. (2015). Use of Fish as Bio-indicator of the Effects of Heavy Metals Pollution. Journal of Aquaculture Research & Development, 6(4), 1–13. DOI:10.4172/2155-9546.1000328
• Başaran, B. (2022). An assessment of heavy metal level in infant formula on the market in Turkey and the hazard index. Journal of Food Composition and Analysis, 105, 104258. DOI:10.1016/j.jfca.2021.104258
• Bernhoft, R. A. (2012). Mercury Toxicity and Treatment: A Review of the Literature. Journal of Environmental and Public Health, 2012, 1–10. DOI:10.1155/2012/460508
• Bosch, A. C., O’Neill, B., Sigge, G. O., Kerwath, S. E. & Hoffman, L. C. (2016). Heavy metals in marine fish meat and consumer health: a review. Journal of the Science of Food and Agriculture, 96(1), 32–48. DOI:10.1002/jsfa.7360
• Botwe, B. O. (2021). Heavy metal concentrations in five fish species from the Gulf of Guinea and their human health implications. Regional Studies in Marine Science, 44, 101763. DOI:10.1016/j.rsma.2021.101763
• Castro-González, M. I. & Méndez-Armenta, M. (2008). Heavy metals: Implications associated to fish consumption. Environmental Toxicology and Pharmacology, 26(3), 263–271.
• Chen, P., Bornhorst, J. & Aschner, M. A. (2018). Manganese metabolism in humans. Frontiers in Bioscience, 1655–1679.
• Copat, C., Arena, G., Fiore, M., Ledda, C., Fallico, R., Sciacca, S. & Ferrante, M. (2013). Heavy metals concentrations in fish and shellfish from eastern Mediterranean Sea: Consumption advisories. Food and Chemical Toxicology, 53, 33–37. DOI:10.1016/j.fct.2012.11.038
• Dambrosio, A., Normanno, G., Storelli, A., Barone, G., Ioanna, F., Errico, L., Centoducati, G. & Storelli, M. M. (2016). Aspects of Vietnamese Sutchi Catfish (Pangasius Hypophthalmus) Frozen Fillet Quality: Microbiological Profile and Chemical Residues. Journal of Food Safety, 36(4), 532–536. DOI:10.1111/jfs.12273
• Dehghani, A., Roohi, A. A. & Dehghani, A. (2022). Trophic transfer, bioaccumulation, and health risk assessment of heavy metals in Aras River: case study—Amphipoda- zander – human. Environmental Science and Pollution Research, 1–10. DOI:10.1007/s11356-021-18036-7
• Denkhaus, E. & Salnikow, K. (2002). Nickel essentiality, toxicity, and carcinogenicity. Critical Reviews in Oncology/Hematology, 42(1), 35–56. DOI:10.1016/S1040-8428(01)00214-1
• Duarte, G. S. C., Takemoto, R. M., Yamaguchi, M. U., Matos, L. S. & Pavanelli, G. C. (2019). Evaluation of the concentration of heavy metals in fillets of Pangasius hypophthalmus (Sauvage, 1878), Panga, imported from Vietnam. Int J Dev Res, 9(10), 30181–30186.
• Duda-Chodak, A. & Blaszczyk, U. (2008). The impact of nickel on human health. Journal of Elementology, 13(4), 685–693.
• EFSA (2009). Scientific opinion on arsenic in food, CONTAM (EFSA Panel on Contaminants in the Food Chain). EFSA Journal, 7(10), 1351.
• Elnimr, T. (2011). Evaluation of some heavy metals in Pangasius hypothalmus and Tilapia nilotica and the role of acetic acid in lowering their levels. International Journal of Fisheries and Aquaculture, 3(8), 151–157.
• EPA (US Environmental Protection Agency) (1980). Ambient water quality criteria document for nickel EPA-440/4-80-060, NTIS PB 81-117715. Cincinnati: OH-US Environmental Criteria and Assessment Office (ECAO).
• EPA (US Environmental Protection Agency) (1989). Assessing Human Health Risks from Chemically Contaminated Fish and Shellfish: A Guidance Manual.
• Fair, P. A., White, N. D., Wolf, B., Arnott, S. A., Kannan, K., Karthikraj, R. & Vena, J. E. (2018). Persistent organic pollutants in fish from Charleston Harbor and tributaries, South Carolina, United States: A risk assessment. Environmental Research, 167, 598–613. DOI:10.1016/j.envres.2018.08.001
• FAO (Food Administration Organization) (2017). Food Balance Sheets.
• Hajrić, D., Smajlović, M., Antunović, B., Smajlović, A., Alagić, D., Tahirović, D., Brenjo, D., Clanjak-Kudra, E., Djedjibegovic, J., Porobic, A. & Poljak, V. (2022). Risk assessment of heavy metal exposure via consumption of fish and fish products from the retail market in Bosnia and Herzegovina. Food Control, 133, 108631. DOI:10.1016/j.foodcont.2021.108631
• Herrera-Herrera, C., Fuentes-Gandara, F., Zambrano-Arévalo, A., Higuita, F. B., Hernández, J. P. & Marrugo-Negrete, J. (2019). Health Risks Associated with Heavy Metals in Imported Fish in a Coastal City in Colombia. Biological Trace Element Research, 190(2), 526–534. DOI:10.1007/s12011-018-1561-1
• Jayanthi, R., Rao, V. A., Babu, R. N., Sivakumar, T., Sriram, P. & Abraham, R. J. J. 2019. Analysis of essential heavy metals in ready-to-eat chicken meat products of Chennai city. Journal of Entomology and Zoology Studies, 7(3), 427–432.
• Köker, L., Aydın, F., Gaygusuz, Ö., Akçaalan, R., Çamur, D., İlter, H., Ayoğlu, N. F., Topbaş, M. & Albay, M. (2021). Heavy Metal Concentrations in Trachurus Mediterraneus and Merlangius Merlangus Captured from Marmara Sea, Turkey and Associated Health Risks. Environmental Management, 67(3), 522–531. DOI:10.1007/s00267-020-01352-y
• Korkmaz, C., Ay, Ö., Ersoysal, Y., Köroğlu, M. A. & Erdem, C. (2019). Heavy metal levels in muscle tissues of some fish species caught from north-east Mediterranean: Evaluation of their effects on human health. Journal of Food Composition and Analysis, 81, 1–9. DOI:10.1016/j.jfca.2019.04.005
• Kosker, A. R. (2020). Metal and fatty acid levels of some commercially important marine species from the northeastern Mediterranean: benefits and health risk estimation. Environmental Monitoring and Assessment, 192(6), 1–16.
• Kubier, A., Wilkin, R. T. & Pichler, T. (2019). Cadmium in soils and groundwater: A review. Applied Geochemistry, 108, 104388. DOI:10.1016/j.apgeochem.2019.104388
• Kukusamude, C., Sricharoen, P., Limchoowong, N. & Kongsri, S. (2021). Heavy metals and probabilistic risk assessment via rice consumption in Thailand. Food Chemistry, 334, 127402. DOI:10.1016/j.foodchem.2020.127402
• Kumari, B., Kumar, V., Sinha, A. K., Ahsan, J., Ghosh, A. K., Wang, H. & DeBoeck, G. (2017). Toxicology of arsenic in fish and aquatic systems. Environmental Chemistry Letters, 15(1), 43–64. DOI:10.1007/s10311-016-0588-9
• Leyssens, L., Vinck, B., Van Der Straeten, C., Wuyts, F. & Maes, L. (2017). Cobalt toxicity in humans—A review of the potential sources and systemic health effects. Toxicology, 387, 43–56. DOI:10.1016/j.tox.2017.05.015
• Li, Y., Wang, X., Du, H, Xiao, G. & Guo, L. (2022). Heavy metal accumulation and health risk assessment of crayfish in the middle and lower reaches of Yangtze River during 2015–2017. Environmental Monitoring and Assessment, 194(1), 24. DOI:10.1007/s10661-021-09652-4
• Łuszczek-Trojnar, E., Błoniarz, P., Winiarski, B., Drąg-Kozak, E. & Popek, W. (2015). Comparison of cadmium, zinc, manganese and nickel concentrations in fillets of selected species of food fish. Scientific Annals of the Polish Society of Animal Production, 11, 75–84.
• Maanan, M. (2008). Heavy metal concentrations in marine molluscs from the Moroccan coastal region. Environmental Pollution, 153(1), 176–183. DOI:10.1016/j.envpol.2007.07.024
• Molognoni, L., Vitali, L., Ploêncio, L. A., Santos, J. N. & Daguer, H. (2016). Determining the arsenic, cadmium, lead, copper and chromium contents by atomic absorption spectrometry in Pangasius fillets from Vietnam. Journal of the Science of Food and Agriculture, 96(9), 3109–3113. DOI:10.1002/jsfa.7486
• Mortuza, M. G. & Al-Misned, F. A. (2015). Trace elements and heavy metals in five cultured and captured fishes from Rajshahi City, Bangladesh. Biomedical Sciences Today, 1, 1–9.
• Mwakalapa, E. B., Simukoko, C. K., Mmochi, A. J., Mdegela, R. H., Berg, V., Bjorge Müller, M. H., Lyche, J. L. & Polder, A. (2019). Heavy metals in farmed and wild milkfish (Chanos chanos) and wild mullet (Mugil cephalus) along the coasts of Tanzania and associated health risk for humans and fish. Chemosphere, 224, 176–186. DOI:10.1016/j.chemosphere.2019.02.063
• Orban, E., Nevigato, T., Lena, G. D., Masci, M., Casini, I., Gambelli, L. & Caproni, R. (2008). New trends in the seafood market. Sutchi catfish (Pangasius hypophthalmus) fillets from Vietnam: Nutritional quality and safety aspects. Food Chemistry, 110(2), 383–389. DOI:10.1016/j.foodchem.2008.02.014
• Özden, Ö. & Erkan, N. (2016). Evaluation of Risk Characterization for Mercury, Cadmium, Lead and Arsenic Associated with Seafood Consumption in Turkey. Exposure and Health, 8(1), 43–52. DOI:10.1007/s12403-015-0181-7
• Pandion, K., Khalith, S. B. M., Ravindran, B., Chandrasekaran, M., Rajagopal, R., Alfarhan, A., Chang, S. W., Ayyamperumal, R., Mukherjee, A. & Arunachalam, K. D. (2022). Potential health risk caused by heavy metal associated with seafood consumption around coastal area. Environmental Pollution, 294, 118553. DOI:10.1016/j.envpol.2021.118553
• Pragnya, M., Dinesh, K. S., Solomon Raju, A. J. & Murthy, L. N. (2020). Bioaccumulation of heavy metals in different organs of Labeo rohita, Pangasius hypophthalmus, and Katsuwonus pelamis from Visakhapatnam, India. Marine Pollution Bulletin, 157, 111326. DOI:10.1016/j.marpolbul.2020.111326
• Rakib, M. R. J., Jolly, Y. N., Enyoh, C. E., Khandaker, M. U., Hossain, M. B., Akther, S., Alsubaie, A., Almalki, A. S. A., Bradley, D. A. (2021). Levels and health risk assessment of heavy metals in dried fish consumed in Bangladesh. Scientific Reports, 11(1), 14642. DOI:10.1038/s41598-021-93989-w
• Ratnaike, R. N. (2003). Acute and chronic arsenic toxicity. Postgraduate Medical Journal, 79(933), 391–396. DOI:10.1136/pmj.79.933.391
• Rodríguez, M., Gutiérrez, Á. J., Rodríguez, N., Rubio, C., Paz, S., Martín, V., Revert, C. & Hardisson, A. (2018). Assessment of mercury content in Panga (Pangasius hypophthalmus). Chemosphere, 196, 53–57. DOI:10.1016/j.chemosphere.2017.12.137
• Ruiz-de-Cenzano, M., Beser, U., Cervera, M. L., & de la Guardia, M. 2013. Fast determination of fish mineral profile. Application to Vietnamese panga fish. Ecotoxicology and Environmental Safety, 95, 195–201. DOI:10.1016/j.ecoenv.2013.06.003
• Santamaria, A. B. (2008). Manganese exposure, essentiality & toxicity. Indian Journal of Medical Research, 128(4), 484–500.
• Simionov, I. A., Cristea, V., Petrea, S. M. & Sirbu, E. B. (2019). Evaluation Of Heavy Metals Concentration Dynamics in Fish From The Black Sea Coastal Area: An Overview. Environmental Engineering and Management Journal, 18(5), 1097–1110. DOI:10.30638/eemj.2019.106
• Soegianto, A., Putranto, T. W. C., Lutfi, W., Almirani, F. N., Hidayat, A. R., Muhammad, A., Firdaus, R. A., Rahmadhani, Y. S., Fadila, D. A. N. & Hidayati, D. (2020). Concentrations of Metals in Tissues of Cockle Anadara granosa (Linnaeus, 1758) from East Java Coast, Indonesia, and Potential Risks to Human Health. International Journal of Food Science, 2020, 1–9. DOI:10.1155/2020/5345162
• Solgi, E. & Beigzadeh-Shahraki, F. (2019). Accumulation and Human Health Risk of Heavy Metals in Cultured Rainbow Trout (Oncorhynchus mykiss) Form Different Fish Farms of Eight Cities of Chaharmahal and Bakhtiari Province, Iran. Thalassas: An International Journal of Marine Sciences, 35(1), 305–317. DOI:10.1007/s41208-019-0123-4
• Stancheva, M., Peycheva, K. & Makedonski, L. (2010). Assessment of heavy metal distribution in muscle, skin and gills of two fish species from the Black Sea, Bulgaria. Scientific Works of the University of Plovdiv, LVII(part 2), 41.
• Stern, B. R., Solioz, M., Krewski, D., Aggett, P., Aw T-C, Baker, S., Crump, K., Dourson, M., Haber, L., Hertzberg, R., Keen, C., Meek, B., Rudenko, L., Schoeny, R., Slob, W. & Starr, T. (2007). Copper and Human Health: Biochemistry, Genetics, and Strategies for Modeling Dose-response Relationships. Journal of Toxicology and Environmental Health, Part B, 10(3), 157–222. DOI:10.1080/10937400600755911
• Töre, Y., Ustaoğlu, F., Tepe, Y. & Kalipci, E. (2021). Levels of toxic metals in edible fish species of the Tigris River (Turkey); Threat to public health. Ecological Indicators, 123, 107361. DOI:10.1016/j.ecolind.2021.107361
• US EPA (2000). Guidance for Assessing Chemical Contaminant Data for Use in Fish Advisories, Volume II. Risk Assessment and Fish Consumption Limits.
• US EPA (2019). Regional screening levels (RSLs) – equations. Retrieved from https://www.epa.gov/risk/regional-screening-levels-rsls-equations
• Varol, M., Kaya, G. K. & Sünbül, M. R. (2019). Evaluation of health risks from exposure to arsenic and heavy metals through consumption of ten fish species. Environmental Science and Pollution Research, 26(32), 33311–33320. DOI:10.1007/s11356-019-06450-x
• Varol, M. & Sünbül, M. R. (2018). Multiple approaches to assess human health risks from carcinogenic and non-carcinogenic metals via consumption of five fish species from a large reservoir in Turkey. Science of The Total Environment, 633, 684–694. DOI:10.1016/j.scitotenv.2018.03.218
• WHO (1989). Evaluation of certain food additives and the contaminants mercury, lead and cadmium.
• Zaynab, M., Al-Yahyai, R., Ameen, A., Sharif, Y., Ali, L., Fatima, M., Khan, K. A. & Li, S. (2022). Health and environmental effects of heavy metals. Journal of King Saud University - Science, 34(1), 101653. DOI:10.1016/j.jksus.2021.101653