Isorhamnetin as a promising natural bioactive flavonoid: in vitro assessment of its antifungal property

Tuba Unver

doi:10.31015/jaefs.2024.1.6

EN

Isorhamnetin as a promising natural bioactive flavonoid: in vitro assessment of its antifungal property

Abstract

Isorhamnetin (3’-methylquercetin) is an important flavonoid produced as a secondary metabolite from medicinal and aromatic plants due to its pharmacological and therapeutic properties. Thus far, the anticancer, antiallergic, antiinflammatory, antioxidant, antiviral, and antimicrobial properties of isorhamnetin have been evaluated in indirect studies conducted with isorhamnetin found in plant extracts or essential oils or direct studies performed with pure isorhamnetin. However, this is the first study in the literature on the antifungal activity of 97% pure isorhamnetin against C. tropicalis, C. albicans, C. krusei, and C. parapsilosis using two assays including agar dilution and broth microdilution methods. This study showed that isorhamnetin has a significant inhibitory effect against all Candida species used. The minimum inhibitory concentration (MIC) value of isorhamnetin against C. tropicalis, C. albicans, C. krusei, and C. parapsilosis was 1.875 mg/mL, the same for all yeast strains. These results have opened a new horizon regarding the usability of isorhamnetin as a pharmacological therapeutic antifungal agent.

Keywords

Isorhamnetin, Flavonoids, Antifungal Activity, Pharmaceutical compound, Therapy

Project Number

TSA-2022-3110

Ethical Statement

Ethics committee approval is not required.

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Details

Primary Language

English

Subjects

Medicinal and Aromatic Plants

Journal Section

Research Article

Authors

Tuba Unver ^*
0000-0002-8655-2716
Türkiye

Publication Date

March 25, 2024

Submission Date

November 17, 2023

Acceptance Date

January 13, 2024

Published in Issue

Year 2024 Volume: 8 Number: 1

DOI

https://doi.org/10.31015/jaefs.2024.1.6

IZ

https://izlik.org/JA77BC67LJ

APA

Unver, T. (2024). Isorhamnetin as a promising natural bioactive flavonoid: in vitro assessment of its antifungal property. International Journal of Agriculture Environment and Food Sciences, 8(1), 54-61. https://doi.org/10.31015/jaefs.2024.1.6

AMA

1.Unver T. Isorhamnetin as a promising natural bioactive flavonoid: in vitro assessment of its antifungal property. int. j. agric. environ. food sci. 2024;8(1):54-61. doi:10.31015/jaefs.2024.1.6

Chicago

Unver, Tuba. 2024. “Isorhamnetin As a Promising Natural Bioactive Flavonoid: in Vitro Assessment of Its Antifungal Property”. International Journal of Agriculture Environment and Food Sciences 8 (1): 54-61. https://doi.org/10.31015/jaefs.2024.1.6.

EndNote

Unver T (March 1, 2024) Isorhamnetin as a promising natural bioactive flavonoid: in vitro assessment of its antifungal property. International Journal of Agriculture Environment and Food Sciences 8 1 54–61.

IEEE

[1]T. Unver, “Isorhamnetin as a promising natural bioactive flavonoid: in vitro assessment of its antifungal property”, int. j. agric. environ. food sci., vol. 8, no. 1, pp. 54–61, Mar. 2024, doi: 10.31015/jaefs.2024.1.6.

ISNAD

Unver, Tuba. “Isorhamnetin As a Promising Natural Bioactive Flavonoid: in Vitro Assessment of Its Antifungal Property”. International Journal of Agriculture Environment and Food Sciences 8/1 (March 1, 2024): 54-61. https://doi.org/10.31015/jaefs.2024.1.6.

JAMA

1.Unver T. Isorhamnetin as a promising natural bioactive flavonoid: in vitro assessment of its antifungal property. int. j. agric. environ. food sci. 2024;8:54–61.

MLA

Unver, Tuba. “Isorhamnetin As a Promising Natural Bioactive Flavonoid: in Vitro Assessment of Its Antifungal Property”. International Journal of Agriculture Environment and Food Sciences, vol. 8, no. 1, Mar. 2024, pp. 54-61, doi:10.31015/jaefs.2024.1.6.

Vancouver

1.Tuba Unver. Isorhamnetin as a promising natural bioactive flavonoid: in vitro assessment of its antifungal property. int. j. agric. environ. food sci. 2024 Mar. 1;8(1):54-61. doi:10.31015/jaefs.2024.1.6

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Isorhamnetin as a promising natural bioactive flavonoid: in vitro assessment of its antifungal property

Abstract

Isorhamnetin as a promising natural bioactive flavonoid: in vitro assessment of its antifungal property

Abstract

Keywords

Project Number

Ethical Statement

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

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Cited By

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Unveiling the Chemical Constituents and Inhibitory Roles of Extracts from Pinus Pinea L. Nut and Nutshell: A Novel Source for Pharmaceutical Antimicrobials

Facile engineering of the 2D flaky structured bismuth yttrium oxide for the electrochemical detection of carbofuran in staple food samples

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