Machine Learning Approaches for Prediction of Alzheimer’s Disease

Öz

Alzheimer's Disease (AD) is a disorder that significantly impacts an individual’s behavior, memory, and cognitive functions, ultimately leading to a loss of independence. Early and accurate diagnosis of AD is critical to mitigating its progression and improving patient outcomes, especially as no definitive cure is currently available. This study investigates the application of machine learning algorithms to predict and diagnose AD based on patient symptoms and clinical data. The dataset used in this research includes comprehensive health information from 2,149 patients, with 35 features covering demographic, lifestyle, and medical factors, and no missing values. Seven widely recognized machine learning algorithms—KNN, GNB, SVM, DT, RF, AdaBoost, and XGBoost—were evaluated to determine their effectiveness in disease prediction. Performance was assessed using recall, precision, accuracy, and F1-score metrics, providing a robust evaluation of each model. XGBoost achieved the highest accuracy rate of 95.35%, highlighting its superior predictive capability, while KNN recorded the lowest accuracy at 75.54%. The results demonstrate the strength of machine learning algorithms, particularly ensemble methods like XGBoost, in analyzing complex clinical data for the early detection of Alzheimer’s Disease. These findings underscore the critical role of machine learning in enhancing diagnostic accuracy and enabling timely interventions, which are essential for improving the quality of life for individuals at risk of Alzheimer’s Disease.

Anahtar Kelimeler

• machine learning
• classification
• Alzheimer
• disease prediction

Alzheimer Hastalığının Tahmininde Makine Öğrenmesi Yaklaşımları

Öz

Alzheimer Hastalığı (AD), bir bireyin davranışını, hafızasını ve bilişsel işlevlerini önemli ölçüde etkileyen ve nihayetinde bağımsızlık kaybına yol açan bir hastalıktır. AD'nin erken ve doğru teşhisi, özellikle şu anda kesin bir tedavi bulunmadığından, ilerlemesini hafifletmek ve hasta sonuçlarını iyileştirmek için kritik öneme sahiptir. Bu çalışma, hasta semptomlarına ve klinik verilere dayanarak AD'yi tahmin etmek ve teşhis etmek için makine öğrenimi algoritmalarının uygulamasını araştırmaktadır. Bu araştırmada kullanılan veri seti, demografik, yaşam tarzı ve tıbbi faktörleri kapsayan 35 özellik ve eksik değer içermeyen 2.149 hastadan kapsamlı sağlık bilgilerini içerir. Hastalık tahminindeki etkinliklerini belirlemek için yaygın olarak tanınan yedi makine öğrenimi algoritması - KNN, GNB, SVM, DT, RF, AdaBoost ve XGBoost - değerlendirildi. Performans, her modelin sağlam bir değerlendirmesini sağlayan geri çağırma, kesinlik, doğruluk ve F1 puanı ölçümleri kullanılarak değerlendirildi. XGBoost, üstün tahmin yeteneğini vurgulayan %95,35'lik en yüksek doğruluk oranına ulaşırken, KNN %75,54 ile en düşük doğruluğu kaydetti. Sonuçlar, Alzheimer Hastalığının erken teşhisi için karmaşık klinik verileri analiz etmede makine öğrenimi algoritmalarının, özellikle XGBoost gibi topluluk yöntemlerinin gücünü göstermektedir. Bu bulgular, Alzheimer Hastalığı riski taşıyan bireylerin yaşam kalitesini iyileştirmek için gerekli olan tanı doğruluğunu artırma ve zamanında müdahaleleri mümkün kılmada makine öğreniminin kritik rolünü vurgulamaktadır.

Anahtar Kelimeler

• makine öğrenmesi
• sınıflandırma
• hastalık tahmini
• Alzheimer Hastalığı

Kaynakça

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