Molecular Characterization of Propolis and Royal Jelly Components as Tool for Study of Their Multifunctional Therapeutic Effects
Öz
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Honeybee
products, mainly propolis and royal jelly are becoming a basis for
development of multipurpose multifunctional drugs, which means increased
efficacy compared to previous high-specific synthetic drugs used in human
medicine. High efficacy drugs are effective only for a small part of
population; they have many uncontrollable side effects and can only be used
in limited time. Honeybee products, mainly propolis, offer a variable
composition of physiologically active compounds of honeybee origin and secondary
metabolites of plants that can exhibit together interesting healing
properties as results of synergic effect of all components. The aim of the
work is targeted characterization of chemically defined compounds of propolis
both honeybee and floral origin and study of their physiological properties
separately and in complex. It was found that the water-soluble components of
ethanol propolis extract inhibit the transcription of DNA-dependent RNA
polymerase by eliminating its binding to the DNA promoter (1). Testing of
antimicrobial activity of pinobanksin-3-O-acetate and pinocembrin purified
from poplar propolis showed growth inhibition of Paenibacillus larvae
strains, the major causative agent of American foulbrood of honey bee larvae
disease (2). We present here pharmacological effects of honeybee royal jelly
on the nervous system enhanced by flavonoid Nobiletin (3), applicable for
prevention and/or delay of neurodegeneration in brains of patients with
Alzheimer’s disease. Results are contribution to the practical usage of
propolis and royal jelly in human medicine as well as in prevention of
honeybee colonies against microbial diseases. Acknowledgements: This work was supported by JRJ Co., Ltd.,
Tokyo, Japan |
Anahtar Kelimeler
Kaynakça
- 1. Simúth J, Trnovský J, Jeloková J (1986) Inhibition of bacterial DNA-dependent RNA polymerases and restriction endonuclease by UV-absorbing components from propolis. Pharmazie 41(2): 131-132 2. Bilikova K, Popova M, Trusheva B, Bankova V (2013) New anti-Paenibacillus larvae substances purified from propolis. Apidologie 44 (3): 278-285 3. Fujiwara H, Kogure A, Sakamoto M, Yamakuni T, Mimaki Y, Murata M, Hitomi N, Yamaguchi K, Ohizumi Y (2011) Honeybee Royal Jelly and Nobiletin Stimulate CRE-Mediated Transcription in ERK-Independent and -Dependent Fashions, Respectively, in PC12D Cells. J. Pharmacol Sci 116: 384 - 387