Study of Relationship between Geographical Location of Collection, Chemical Composition and Biological Activity of Propolis by Multivariate Data Analysis
Öz
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Propolis contains resinous material collected by honeybees from
plants, and has a plethora of biological activities. The geographical
location of propolis collection influences its chemical composition,
resulting in variations in biological activity. The present study was
designed to analyse the relationship of propolis to geographic location,
chemical composition and biological activity. We have applied multiple
regression analysis using SPSS to examine selected flavonoids and phenolics
for their individual concentration as well as total content and biological
activities i.e. anti-microbial activity against Staphylococcus aureus
and anti-oxidant activity by DPPH assay. Three climatic zones have been
classified- temperate, subtropical and tropical. This meta-data analysis
revealed some interesting facts about the distribution of specific chemicals
(CAPE, pinocembrin, pinobanksin, galangin, naringenin, chrysin, quercetin,
apigenin, cinnamic acid, coumaric acid, caffeic acid and ferulic acid), as
well as, total phenolic and flavanoid content and biological activity. We
observed that, the phenolics have stronger anti-microbial activity as
compared to flavonoids and vica-verse for anti-oxidant activity. We also
noticed that, total phenolic content is often around 1.5 times higher than
flavonoid content in almost all climatic zones. Higher levels of cinnamates
were observed in propolis from tropical regions which had better
anti-microbial potential, whereas, temperate propolis with higher levels of
flavonoids exhibited better anti-oxidant potential.
Acknowledgement: We acknowledge the financial support from Innovate
UK and Nature’s Laboratory Ltd. (KTP010490). We also acknowledge the
financial support provided by Winston Churchill Memorial Trust (2016-17). |
Anahtar Kelimeler
Propolis,Chemical Composition,Biological Activity,DPPH,Staphylococcus aureus
Kaynakça
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