The clinical relevance of biofilms has become more apparent, however despite
this increased prominence they remain difficult to treat. Biofilm formation
relies on bacterial communication mechanisms known as quorum sensing (QS). QS
presents a novel target for antimicrobials. It is postulated that QS inhibition
would not so readily lead to the development of resistance, a common barrier in
the treatment of infectious disease. This study set out to establish whether
propolis could have an impact on biofilm formation.
Gram positive and negative bacterial species of clinical relevance were
tested, namely Staphylococcus aureus, Escherichia coli and Pseudomonas
aeruginosa. In addition, Chromobacterium violaceum was used to
determine QS inhibition. The effects of an ethanoic extraction of propolis
(0-2.5% v/v) on biofilm formation was assessed using colourimetry. Manuka honey was tested as a comparison due
to its known impact on biofilm formation and QS.
Birincil Dil | İngilizce |
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Bölüm | 2nd Propolis Conference Special Issue |
Yazarlar | |
Yayımlanma Tarihi | 8 Aralık 2018 |
Yayımlandığı Sayı | Yıl 2018 Cilt: 1 Sayı: 3 - 2nd Propolis Conference Special Issue |