Autologue Skin Microbiota Transplantation In Cats With Primary/Secondary Skin Lesions: Route For Substituting Cutaneous Integumentary System Against Allergy
Abstract
Feline integumentary environment and its biogeography might display microbial dysbiosis with an enrichment of specifical pathogens, which have also been implicated in dermatological issues in cats. Primary and secondary skin lesions might be frequently observed in cats which are quite commonly underdiagnosed causing core skin microbiome default. Moreover recent researches supported the participation of the skin microbiome in several dermatological issues among cats, there has been knowledge gaps for natural treatment. To this sense we aimed to substitute diseased and perturbated skin microbiome to those of healthy adjacent microbiogeography by use of Nivea Refining Clear-Up Strips (Ni-RcUs) in cats with primary/secondary skin lesions. Briefly this autologue skin microbiota transplantation (a-SmT) technique instead of what have been used properly as heterologue skin microbiota transplantation (h-SmT) by the same reserachers group, involved transfer of cutaneous microbiome from adjacent healthy tissue to pertubated skin of same case by use of Ni-RcUs. In a total of 50 cats with a history of non-seasonal pruritus, miliary dermatitis, eosinophilic dermatitis, alopecia or excoriation, following tentative diagnosis of allergy, the severity and distribution of clinical dermatological lesions were assessed using SCORFAD (SCORing Feline Allergic Dermatitis) system. To this sense a-SmT has been performed to all 50 cats with a well established and performed methodology (by the same group of investigators of this manuscript), in which adjacent healthy tissue microbiome was substituted and replaced to diseased skin. Following completion of a-SmT there was significant clinical recovery in which mean excoriation, miliary dermatitis, eosinophilic dermatitis and self-induced alopecia scores were totally decreased [2.50 vs. 0.74, 1.52 vs. 0.42, 0.22 vs. 0.00 and 3.48 vs. 0.74, before and after treatment, respectively] (p <0.001). Moreover mean total cumulative SCORFAD values were deemed significantly (p <0.001) decreased [7,63 vs. 2.06]. In conclusion this natural route of unmatched treatment modality should replace, previously used old fashioned drug trials of immunosuppressive origin.
Keywords
Autologue Skin Microbiota Transplantation, Feline Dermatology, SCORFAD, Cutaneous Dysbiosis
References
- Boxberger, M., Cenizo, V., Cassir, N., and La Scola, B. 2021. Challenges in exploring and manipulating the human skin microbiome. Microbiome, 9: 125. https://doi.org/10.1186/s40168-021-01062-5
- Callewaert, C. 2025. Skin microbiome manipulations. In A. Lauerma, N. Fyhrquist, H. I. Maibach, & B. Homey (Eds.), The Skin Microbiome Manual, 257–273. Springer, Cham.
- Callewaert, C., Knödlseder, N., Karoglan, A., Güell, M., and Paetzold, B. 2021. Skin microbiome transplantation and manipulation: Current state of the art. Computational and Structural Biotechnology Journal, 19: 624–631. https://doi.org/10.1016/j.csbj.2021.01.001
- Junca, H., Pieper, D. H., and Medina, E. 2022. The emerging potential of microbiome transplantation on human health interventions. Computational and Structural Biotechnology Journal, 20:615–627. https://doi.org/10.1016/j.csbj.2022.01.009
- Mahmud, R. M., Akter, S., Khanam Tamanna, S., Mazumder, L., Esti, I. Z., Banerjee, S., Akter, S., Hasan, M.R., Acharjee, M., Hossain, M.S., and Pirttila, A.M. 2022. Impact of gut microbiome on skin health: Gut-skin axis observed through the lenses of therapeutics and skin diseases. Gut Microbes, 14: e2096995. https://doi.org/10.1080/19490976.2022.2096995
- Steffan, J., Olivry, T., Forster, S. L., and Seewald, W. 2012. Responsiveness and validity of the SCORFAD, an extent and severity scale for feline hypersensitivity dermatitis. Veterinary Dermatology, 23(5): 410–e77. https://doi.org/10.1111/j.1365-3164.2012.01071.x
- Sun, C., Chen, L., Yang, H., Sun, H., Xie, Z., Zhao, B., Jiang, X., Qin, B., and Shen, Z. 2021. Involvement of gut microbiota in the development of psoriasis vulgaris. Frontiers in Nutrition, 8: 761978. https://doi.org/10.3389/fnut.2021.761978
- Ural, K., Erdoğan, H., and Erdoğan, S. 2022a. A new era under soil-based probiotics for anti-pruritic combat among cats with feline atopic skin syndrome. International Journal of Veterinary and Animal Research, 5(2): 89–93. https://doi.org/10.5281/zenodo.7020543
- Ural, K., Erdoğan, H., and Erdoğan, S. 2022b. Heterologue skin microbiota transplantation for treatment of sarcoptic mange in two dogs with zoonotic transmission. Bozok Veterinary Sciences, 3(2): 52–56. https://doi.org/10.58833/bozokvetsci.1207900
- Ural, K., Erdoğan, H., and Erdoğan, S. 2023a. Skin microbiota transplantation by Nivea Refining Clear-Up Strips could reverse erythema scores in dogs with atopic dermatitis: Novel strategy for skin microbiome manipulation: Cohort study. Türkiye Klinikleri Journal of Veterinary Sciences, 14(1). https://doi.org/10.5336/vetsci.2022-93888