Tear levels of macrophage migration inhibitory factor in vernal keratoconjunctivitis

Abstract

Objective: The pathogenesis of vernal keratoconjunctivi­tis (VKC) is not fully understood and cannot be explained only with type I hypersensitivity reaction. The aim of this study was to determine the Macrophage migration inhibi­tory factor (MIF) levels in tear fluids of patients with VKC. Methods: Tear fluid samples were collected with micro­capillary tubes for hematocrit at the lateral canthus of patients in the supine position without any anesthesia. Tear levels of MIF were measured by ELISA kit. Tear fluid samples were collected from 10 healthy subjects and 20 patients with VKC. Results: Tear levels of MIF in patients with VKC were significantly higher than those in controls (p

Keywords

• Macrophage migration inhibitory factor, ver­nal keratoconjunctivitis, ELISA

Vernal keratokonjonktivitte gözyaşı makrofaj migrasyon inhibitör faktör düzeyleri

Öz

Amaç: Vernal keratokonjonktivitin (VKC) patogenezi tam olarak anlaşılamamış olup, sadece Tip I aşırı duyarlılık cevabıyla açıklanamamaktadır. Bu çalışmada VKC hasta­larının gözyaşı makrofaj migrasyon inhibitör faktör (MIF) düzeyini araştırmak amaçlanmıştır. Yöntemler: Gözyaşı örnekleri topikal anestezi damlatma­dan lateral kantusa yerleştirilen hematokrit tüplerine alın­dı. MIF düzeyleri ELISA yöntemi ile incelendi. Çalışmaya 20 VKC hastası ve 10 sağlıklı birey dahil edildi. Sonuç: Kontrol grubu ile karşılaştırıldığında VKC\'li hasta­larda gözyaşı MIF seviyeleri anlamlı olarak daha yüksek bulundu (p

Anahtar Kelimeler

• Makrofaj migrasyon inhibitör faktör, vernal keratokonjonktivit, ELISA

Kaynakça

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