Pregabalin ilişkili döküntü: Olgu sunumu

Öz

Kırksekiz yaşında ve 2 aydır nöropati tedavisi için 300 mg/gün oral yolla pregabalin kullanan erkek hasta, eks­tremiteler ve lomber bölgesinde eritematöz, makülopapü­ler döküntü şikayeti ile başvurdu. Naranjo olasılık skalası döküntü ve pregabalin kullanımı arasında muhtemel bir ilişkiyi gösterdi. Pregabalin tedavisi kesilerek, antihistami­nik tedavi, oral metilprednizolon ve topical steroidli krem başlandı. Tedavinin kesilmesinden 1 hafta sonra döküntü neredeyse tamamen düzeldi. Pregabalin ilişkili döküntü faz 3 klinik çalışmalarda nadiren rapor edilmiştir. Prega­balin kullanımına eşlik eden döküntü daha önce yalnızca bir vaka raporunda sunulmuştur. Pregabalin ilişkili dökün­tünün mekanizması tam olarak anlaşılamamıştır. Düşük dozlarda pregabalin tedavisine başlamak ve doz artımını yavaş yapmak yan etki insidansını azaltabilir.

Anahtar Kelimeler

• pregabalin, döküntü, multipl myelom

Rash associated with Pregabalin: A case report

Öz

A 48-year-old man with erythematous, maculopapular rash localized to his extremities and lumbar region that he had been receiving oral pregabalin 300 mg per day for 2 months to treat his neuropathy was applied. The Nara­njo probability scale indicates a probable relationship be­tween the development of rash and use of pregabalin by our patient. Pregabalin was discontinued and antihista­minic treatment, oral methyprednisolone and topical ste­roid cream were given to treat the rash. The rash almost completely resolved one week after pregabalin was dis­continued. Pregabalin-induced rash was rarely reported in Phase 3 clinical trials, and there is currently only one available report on the development of a rash coinciding with the use of pregabalin. No clear mechanisms reported for rash associated with pregabalin. It is usually recom­mended to start pregabalin with low doses and slow in­creases might prevent the incidence of side effects. J Clin Exp Invest 2013; 4 (1): 107-109

Anahtar Kelimeler

• pregabalin, rash, multiple myelom

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