Relationship between Oxidative Stress Markers and Cardiac Syndrome X

Abstract

Objectives: To investigate the alterations of oxidative and antioxidative status in patients with cardiac syndrome X (CSX). Materials and methods: Thirty-three patients with CSX (CSX group), 27 patients without CSX (NSX) and 20 healthy volunteers as control group were included into the study. Oxidative status of serum was evaluated by measuring total oxidant status (TOS), lipid hydroperoxide levels (LOOH) and oxidative stress index (OSI) of serum, and antioxidative status of serum was evaluated by measuring total antioxidant capacity (TAC). Also, hsCRP and other biochemical markers were measured in all subjects. Results: The oxidants (TOS, LOOH and OSI) and CRP levels were higher, and TAC was lower in the patients with CSX than NSX group and control group. Also, the oxidants (TOS, LOOH and OSI) and hsCRP levels, a marker of chronic inflammation, were higher, and TAC was lower in the patients with NSX than control group. In addition, in patients with CSX, a significant positive correlation (ß =0.606, p

Keywords

• Oxidative stress, oxidant, antioxidant, cardiac syndrome X

Relationship between Oxidative Stress Markers and Cardiac Syndrome X

Öz

Amaç: Biz bu çalışmada kardiyak sendrom X\'li (CSX) hastalarda oksidatif ve antioksidatif durumlardaki değişimi araştırdık. Gereç ve yöntem: Çalışmamıza 33 CSX\'li hasta, 27 CSX tanısı olmayan (NSX) hasta ve kontrol grubu olarak 20 sağlıklı gönüllüyü dahil ettik. Serumun oksidatif durumu total oksidan durum (TOS), lipid hidroperoksid seviyesi (LOOH) ve serum oksidatif stres indeksi ölçülerek (OSİ) değerlendirildi. Serumun antioksidatif durumu ise total antioksidan kapasite (TAC) ölçülerek değerlendirildi. Ayrıca tüm vakalarda hsCRP ve diğer biyokimyasal belirteçler ölçüldü. Bulgular: CSX grubunda NSX ve kontrol grubuna göre oksidan seviyeleri (TOS, LOOH ve OSI) ve CRP seviyeleri daha yüksekken, TAC seviyeleri daha düşük bulundu. Ayrıca NSX grubunda kontrol grubuna göre oksidanlar (TOS, LOOH ve OSI) ve kronik enflamasyonun bir belirteci olan hsCRP seviyeleri daha yüksekken TAC seviyeleri daha düşük olarak saptandı. Bunlara ek olarak CSX\'li hastalarda OSİ seviyesi ve ST depresyonu arasında istatistiksel olarak anlamlı bir korelasyon mevcuttu (r; 0.784, ß =0,606, p

Anahtar Kelimeler

• Oksidatif stres, oksidan, antioksidan, kardiyak sendrom X.

Kaynakça

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