Retrospective Analysis of the patients with gynecological cancer: 11-Year Experience

Abstract

Objectives: We planned this study with the aim of obtaining knowledge about epidemiological characteristics of gynecological malignancies followed up in our hospital. Materials and methods: In our study we analyzed 231 patients that were operated with the appraisal diagnosis of gynecological cancer in Gynecology and Obstetrics Department of Dicle University Medical Faculty between the dates of 2001, January and 2011, November. Results: The mostly diagnosed gynecological malignancy was ovarian cancers among the gynecological cancers seen in the first group compassing the period between the year 2001 and the first half-term of the year 2006. In the second group compassing the period from the second half-term of the year 2006 to the end of the year 2011, ovarian cancers were again the most frequently seen gynecological cancers. On the other hand it was found that there was an increase in the percentage of endometrial cancers. While cases with advanced staged constituting the major part of the patients with ovarian cancer, it was seen that the majority of the patients with endometrium cancer were consisting of stage 1 cases. In the 4 of 6 cases having endometrium cancer and applying with the complaint of pain, the disease was noticed in the advanced stage. Being the most frequently seen gynecological cancer all over the world and especially in the societies with lower socio-economic status, the cervix cancer was taking place in the 3rd order after endometrium cancer in terms of frequency in our region. Conclusion: Consequently, in the recent years the gynecological cancer showing the most frequent increase was endometrium cancer in our region. The increase in the frequency of obesity, relating with the reasons like the improper nutrition behavior, the increase in the socio-economic status, may be associated with the increase in the frequency of endometrium cancer. The healthcare personals and the public body must be instructed to diagnose the gynecological cancer cases especially the ones having ovarian cancer in the early stage. J Clin Exp Invest 2012; 3(2): 209-213

Keywords

• Ovarian cancer, uterine cancer, cervical cancer, cancer epidemiology

Jinekolojik kanserli olguların retrospektif analizi: 11 yıllık deneyim

Öz

Amaç: Hastanemizde izlenen jinekolojik kanserlerinin epidemiyolojik özellikleri hakkında fikir vermek amacıyla bu çalışmamızı planladık. Gereç ve yöntem: Çalışmamızda Dicle Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Kliniğinde Ocak 2001 ile Kasım 2011 tarihleri arasında jinekolojik kanser ön tanısı ile ameliyat edilen 231 hasta geçmişe yönelik incelendi. Bulgular: 2001-2006 yılı ilk yarısı arası dönemi kapsayan ilk grup jinekolojik kanserler arasında en sık tanı konan over kanserleridir. 2006 yılı ikinci yarısından 2011 yılı sonuna kadar olan dönemi kapsayan ikinci grupta ise en sık jinekolojik kanser yine over kanserleridir. Ancak endometrium kanseri oranında artış olduğu bulundu. Over kanserli hastaların büyük bölümünü ileri evreli olgular oluştururken, endometrium kanserli olguların büyük bölümünün ise evre 1 olgulardan oluştuğu bulundu. Ağrı şikâyeti ile başvuran Endometrium kanserli 6 olgunun 4\' ünde hastalık ileri evrede tanınmıştır. Tüm dünyada ve özellikle de sosyoekonomik düzeyi düşük toplumlarda en sık jinekolojik kanser olan serviks kanseri bölgemizde sıklık bakımından endometrium kanserinden sonra 3. sırada yer almıştır. Sonuç: Sonuç olarak, bölgemizde son yıllarda en sık artış gösteren jinekolojik kanser endometrium kanseridir. Kötü beslenme, sosyoekonomik düzeyin yükselmesi gibi nedenlerle artan obezite sıklığı ile endometirum kanseri sıklığı artışı ilişkili olabilir. Özellikle over kanserli olguların erken evre de tanı konulabilmesi için sağlık çalışanları ve halk bilgilendirilmelidir.

Anahtar Kelimeler

• Over kanseri, uterin kanser, serviks kanseri, kanser epidemiyolojisi

Kaynakça

1. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010;60(5):277-300.
2. Boyle P, Ferlay J. Cancer incidence and mortality in Europe, 2004. Ann Oncol 2005;16(3):481-8.
3. Ferlay J, Shin HR, Bray F, et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010;127(12):2893-917.
4. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005;55(2):74-108.
5. Parkin DM, Bray F, Ferlay J, Pisani P. Estimating the world cancer burden: Globocan 2000. Int J Cancer 2001;94(2):153-6.
6. Sorosky. JI. Endometrial cancer. Obstet Gynecol 2008;111(2):436-47.
7. Molarius A, Seidel JC, Sans S, et al. Varying sensitivity of waist action levels to identify subjects with over- weight or obesity in populations of the WHO MONICA Project. J Clin Epidemiol 1999;52(12):1213-24.
8. Sur H, Kolotourou M, Dimitriou M, et al. Biochemical and behavioral indices related to BMI in schoolchil- dren in urban Turkey. Prev Med 2005;41(2):614-21.

9. Seidman JD, Horkayne-Szakaly I, Haiba M, et al. The histologic type and stage distribution of ovarian car- cinomas of surface epithelial origin. Int J Gynecol Pathol 2004;23(1):41-4.
10. Schorge JO, et al. Epithelial ovarian cancer. In: Schorge JO, Schaffer JI, Halvorson LM, et al. Williams Gynecology, 1st edn. New York, McGraw-Hill Compa- nies, Inc. 2008:716.
11. Creasman WT, Odicino F, Maisonneuve P, et al. Carcinoma of the corpus uteri. J Epidemiol Biostat 2001;6(1):47-86.
12. Atlan D, Touboul E, Deniaud-Alexandre E, et al. Op- erable Stages IB and II cervical carcinomas: a retro- spective study comparing preoperative uterovaginal brachytherapy and postoperative radiotherapy. Int J Radiat Oncol Biol Phys 2002;54(3):780-93.