Comparison of plasma homocysteine levels in patients with type 2 diabetes mellitus with normal subjects

Abstract

Objectives: To compare the plasma homocysteine levels between control group and diabetic patients with no diabetic retinopathy, with preproliferative diabetic retinopathy, with proliferative diabetic retinopathy. Materials and methods: Plasma homocysteine levels of 23 diabetic patients were measured and were compared with 25 age-matched controls with no systemic problem and no ocular disease. Plasma homocysteine levels were measured using high-performance liquid chromatography. Results: Diabetic patients were divided into three groups according to their ophthalmological findings. There were 8 patients with no diabetic retinopathy, 8 patients with preproliferative diabetic retinopathy, 7 patients with proliferative diabetic retinopathy. Plasma homocysteine levels were higher in diabetic patients (13.30±4.03 µmol/L) compared to the control group (11.71±3.41 µmol/L) but no statistically significant difference was found between the two groups (p>0.05). Plasma homocysteine levels were measured 12.50±3.73 µmol/L in no diabetic retinopathy group, 12.90±2.59 µmol/L in preproliferative diabetic retinopathy group, 14.64±5.69 µmol/L in proliferative diabetic retinopathy group. In diabetic group, plasma homocysteine levels increased with the increase of the severity of retinopathy but not reached statistically significance (p>0.05). Conclusion: Although no statistically significance was found, retinopathy progresses with the increase of plasma homocysteine levels. This can be used for the follow-up of the diabetic patients but further evaluation in large groups is needed. J Clin Exp Invest 2012; 3(2): 235-239

Keywords

• Homocysteine, diabetes mellitus, diabetic retinopathy

Tip 2 diabetes mellituslu hastalarda plazma homosistein düzeyinin normal popülasyonla karşılaştırılması

Öz

Amaç: Preproliferatif ve proliferatif diabetik retinopatili hastalar ile retinopatisi olmayan diabetes mellitus hastalarının plazma homosistein düzeylerinin normal popülasyonla karşılaştırılması amaçlanmıştır. Gereç ve yöntem: Tip 2 diabet 23 hastanın plazma homosistein düzeyleri ile benzer yaş grubunda, herhangi bir sistemik hastalığı ve oküler problemi olmayan 25 olgunun plazma homosistein düzeyleri karşılaştırıldı. Homosistein düzeyi yüksek performanslı sıvı kromatografi yöntemi ile ölçüldü. Bulgular: Diabetes mellituslu olgular fundus muayenelerine göre üç gruba ayrıldı. 8 olguda diabetik retinopati bulgusu olmadığı, 8’inde preproliferatif, 7’sinde proliferatif diabetik retinopati olduğu saptandı. Plazma homosistein düzeyi diabetes mellituslu grupta (ortalama 13,30±4,03 µmol/L), kontrol grubuna göre (ortalama 11,71±3,41 µmol/L) yüksek olmakla birlikte her iki grup arasında istatistiksel olarak anlamlı fark bulunmadı (p > 0,05). Diabetes mellituslu grup içinde ise diabetik retinopatisi olmayan grupta plazma homosistein düzeyi ortalaması 12,50±3,73 µmol/L iken, preproliferatif diabetik retinopati grubunda ortalama 12,90±2,59 µmol/L; proliferatif diabetik retinopatisi olan grupta ise ortalama 14,64±5,69 µmol/L düzeyinde saptandı. Ortalama plazma homosistein düzeyi retinopatinin ilerlemesiyle artış göstermekle birlikte bulguların istatistiksel analizinde bu artış anlamlı bulunmadı (p > 0,05). Sonuç: İstatistiksel olarak anlamlı olmamakla birlikte plazma homosistein düzeyinin özellikle retinopati ilerledikçe artması plazma homosistein düzeyinin tip 2 diabetes mellituslu olguların takibinde kullanılabileceğini ancak daha büyük çalışma gruplarının daha kesin bilgi verebileceğini düşündürmektedir.

Anahtar Kelimeler

• Homosistein, diabetes mellitus, diabetik retinopati

Kaynakça

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