Ovarian malignant melanoma presenting with hypercalcemia and bone marrow infiltration: a case report and review of the literature

Öz

Malignant melanoma originating from the ovary is a very rare condition. Bone marrow involvement and hypercalcemia is observed at a very low rate in malignant melanoma cases (5-7 and 1.1-11.9%, respectively). In this paper, we present very rare condition as a 67-year-old female patient with malignant melanoma of ovary origin accompanied by bone marrow infiltration and hypercalcemia.

Anahtar Kelimeler

• Ovarian malign melanoma, bone marrow infiltration, hypercalcemia

Hiperkalsemi ve kemik iliği infiltrasyonu ile başvuran bir overiyan malign melanom: vaka sunumu ve literatür taraması

Öz

Over kaynaklı malign melanom oldukça nadir bir durumdur. Kemik iliği tutulumu olması ve hiperkalsemi varlığı malign melanoma vakalarında çok düşük oranda gözlenmektedir (sırasıyla, % 5-7 and % 1.1-11.9). Bu yazıda biz de kemik iliği infiltrasyonu gösteren ve hiperkalsemisi bulunan oldukça nadir bir 67 yaşında kadın over kaynaklı malign melanoma vakasını sunduk.

Anahtar Kelimeler

• Overiyan malign melanoma, kemik iliği infiltrasyonu, hiperkalsemi

Kaynakça

1. Rigel DS, Friedman RJ, Kopf AW. The incidence of malignant melanoma in the United States: issues as we approach the 21st century. J Am Acad Dermatol 1996;34(6):839-47.
2. Gungor T, Altinkaya SO, Ozat M, Bayramoglu H, Mol- lamahmutoglu L. Primary malignant melanoma of the female genital tract. Taiwan J Obstet Gynecol 2009;48(2):169-75.
3. Irvin WP Jr, Legallo RL, Stoler MH, et al. Vulvar mela- noma: a retrospective analysis and literature review. Gynecol Oncol 2001;83(3):457-65.
4. An JS, Wu LY, Li N, Li B, Yu GZ, Liu LY. Clinical anal- ysis of 42 cases of primary malignant melanoma in female genital tract. Zhonghua Fu Chan Ke Za Zhi 2007;42(5):320-4.
5. Wang Y, Chang W, Pu D. Clinical analysis of 15 pa- tients with primary malignant melanoma in the genital tract. Zhonghua Fu Chan Ke Za Zhi 1997;32(4):226-8.
6. Sugiyama VE, Chan JK, Kapp DS. Management of melanomas of the female genital tract. Curr Opin On- col 2008;20(3):565-9.
7. Batsis JA, Barry MJ. Metastatic malignant melano- ma presenting with hypercalcaemia and bone mar- row involvement. J Eur Acad Dermatol Venereol 2006;20(3):432-4.
8. Savage RA, Lucas FV, Hoffman GC. Melanoma in mar- row aspirates. Am J Clin Pathol 1983, 79(2):268-9.

9. Jain D, Singh T, Kumar N, Daga MK. Metastatic malig- nant melanoma in bone marrow with occult primary site - a case report with review of literature. Diagn Pathol 2007;2:38-41.
10. Gallivan MVE, Lokich JJ. Carcinocythemia (carcino- ma cell leukemia). Cancer 1984; 53(8):1100-2.
11. Basu D, Bhade BA, Ghotekar LH, Mathew T, Dutta TK. Malignant melanoma metastatic to bone marrow. Indian J Pathol Microbiol 2002;45(1):107-9.
12. Schadendorf D, Dorn-Beineke A, Borelli S, Riethmuller G, Pantel K. Limitations of the immunocytochemical detection of isolated tumor cells in frozen samples of bone marrow obtained from melanoma patients. Exp Dermatol 2003;12(1):165-71.
13. Uesawa M, Sato K, Ozaki K, Nagai T, Muroi K, Ozawa K. Bone marrow metastasis of malignant melanoma. Intern Med 2006;45(2):341-6.
14. Wong KF. Metastatic melanoma. Br J Haematol 2006;134(4):554-8.
15. Lumachi F, Brunello A, Roma A, Basso U. Medical treatment of malignancy-associated hypercalcemia. Curr Med Chem 2008;15(3):415-21.
16. Burt ME, Brennan MF. Hypercalcemia and malignant melanoma. Case reports. Am J Surg 1977;137(5):790- 4.
17. Levy I, Feun L. Hypercalcemia and malignant mela- noma. Am J Clin Oncol 1990;13(4):524-6.
18. Kageshita T, Matsui T, Hirai S, Fukuda Y, Ono T. Hy- percalcemia in melanoma patients associated with increased levels of parathyroid hormone-related pro- tein. Melanoma Res 1999;9(1):69-73.
19. McCluggage WG, Bissonnette JP, Young RH. Primary malignant melanoma of the ovary: a report of 9 defi- nite or probable cases with emphasis on their mor- phologic diversity and mimicry of other primary and secondary ovarian neoplasms. Int J Gynecol Pathol 2006;25(4):321-9.
20. McNeilage LJ, Morgan J, Constable J, Jobling TW. Metastatic malignant melanoma arising in a mature ovarian cystic teratoma: a case report and literature review. Int J Gynecol Cancer 2005; 15(10):1148-52.
21. Boscaino A, D’Antonio A, Orabona P, Tornillo L, Staibano S, De Rosa G. Primary malignant melanoma of the ovary. Pathologica 1995;87(6):685-8.
22. Brown D, Boniuk M, Font RL. Diffuse malignant melanoma of iris with metastases. Surv Ophthalmol 1990;34(5):357-64.
23. Tuncer I, Paydas¸ S, Cos¸ar EF, Ersöz C. Metastatic malignant melanoma in bone marrow: importance of aspiration cytology. Turk J Cancer 1994;24(2):168-70.
24. Bhagwati N, Seno R, Dutcher JP, Oleksowicz L. Ful- minant metastatic melanoma complicated by a mi- croangiopathic hemolytic anemia. Hematopathol Mol Hematol 1998; 11(2):101-8.