BibTex RIS Kaynak Göster

Pemphigus

Yıl 2011, , 468 - 473, 01.12.2011
https://doi.org/10.5799/ahinjs.01.2011.04.0099

Öz

Pemphigus is an uncommon autoimmune mucocutaneous blistering disease, mediated by antibodies directed against proteins present on the surface of keratinocytes that provide mechanical structure to the epidermis. Incidences of the various forms of pemphigus vary from country to country. Pemphigus vulgaris consists of the 80% of pemphigus cases and it occurs 10 times more than pemphigus foliaceus. There have been several recent advances in the management of pemphigus. Treatment of with systemic steroids and cytotoxic immunosuppressants can be highly effective. This article will discuss its epidemiology, pathogenesis, clinical variants and approaches to treatment. J Clin Exp Invest 2011; 2 (4): 468-473

Kaynakça

  • Stanley JR. Pemphigus. In: Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, Eds. Fitz- patrick’s Dermatology in General Medicine. 6th Ed, New York: McGraw-Hill Company 2003:558-67.
  • Amagai M. Vesiculobullous diseases, Pemphigus: In Dermatology. Bolognia JL, Jorizzo JL, Rapini RP 2nd Ed, London: Mosby, 2008;31:417-29.
  • Heng A, Nwanneshıudu A, Hashimoto T. Intraepidermal neutrophilic IgA/IgG antidesmocollin 1 pemphigus. Brit J Dermatol 2006;154(8):1018-9.
  • Uzun S, Durdu M, Akman A, et al. Pemphigus in the Mediterranean region of Turkey: A study of 148 cases. Int J Dermatol 2006;45(4):523-8.
  • Odom RB, James WD, Berger TG. Andrew’s Diseases of the Skin. 9th Ed, Philadelphia: WB Saunders Com- pany 2000:574-605.
  • Ruocco E, Aurilia A, Ruocco V. Precautions and Suggestions for Pemphigus patients. Dermatology 2001;203(2):201-7.
  • Wucherpfennig KW, Yu B, Bhol K, Monos SD, et al. Structural basis for major histocompatibility complex (MHC).-linked susceptibility to autoimmunity: charged residues of a single MHC binding pocket confer se- lective presentation of self-peptides in pemphigus vul- garis. Proc Natl Acad Sci USA 1995;92(22):11935-9.
  • Uzun S. Büllü hastalıklar. Dermatoloji’de. Tüzün Y, Gü- rer MA, Serdaroğlu S, Oğuz O, Aksungur VL, ed. 3. baskı. İstanbul Nobel Tıp Kitabevi, 2008:807-32.
  • Brenner S, Sason A, Sharon O. Pemphigus and Infec- tions. Clin Dermatol 2002;20(1):114-8.
  • Udey MC, Stanley JR. Pemphigus-Diseases of Antides- mosomal Autoimmunity. JAMA 1999;282(6):572-6.
  • Braun-Falco O, Plewig G, Wolff HH, Burgdorf WHC. Dermatology. 2nd Ed, Berlin:Springer-Verlag 2000;649- 95.
  • Nguyen VT, Ndoye A, Grando SA. Pemphigus vulgar- is antibody identifies pemphaxin. A novel keratinocyte annexin-like molecule binding acetylcholine. J Biol Chem 2000;275(38):29466-76.
  • Amagai M. Autoimmunity against desmosomal cad- herins in pemphigus. J Dermatol Sci 1999;20(2):92- 102.
  • Ishii N, Ishida-Yamamoto A, Hashimoto T. Immuno- localization of target autoantigens in IgA pemphigus. Clin Exp Dermatol 2004;29(1):62-6.
  • V’lckova-Laskosa MT, Laskosi DS, Kamberova S, Ca- ca-Biljanovska N, Volckova N. Epidemiology of pem- phigus in Macedonia: A 15-year retrospective study 1990-2004. Int J Dermatol 2007;46(2):253-8.
  • Cohen LM, Skopicki DK, Harrist TJ, Clark WH. Non- infectious Vesiculobullous and Vesiculopustular Dis- eases. In: Elder D, Elenitsas R, Jaworsky C, Johnson B, Eds. Lever’s Histopathology of the Skin. 8th Ed, Philadelphia: Lippincott-Raven 1997:209-52.
  • Bystryn JC, Rudolph JL. Pemphigus. Lancet 2005;366(25):61-73.
  • Uzun S. Otoimmün büllöz hastalıklarda laboratuar tanı. Dermatose 2002;2(1):42-6.
  • Turgutalp SÇ, Harman M. Pemfigusta Seyir ve Prog- noz: 42 hastanın değerlendirilmesi. Dicle Tıp Dergisi 2008;35(1):29-31.
  • Yeh SW, Ahmed B, Sami N, Razzaque A. Blistering disorders: diagnosis and treatment. Dermatol Ther 2003;16(3):214-23.
  • Fellner MJ, Sapadin AN. Current therapy of pemphi- gus vulgaris. Mt Sinai J Med 2001; 68(4-5):268-78.
  • Harman KE, Albert S, Black MM; British Association of Dermatologists. Guidelines for the management of pemphigus vulgaris. Br J Dermatol 2003;149(8):926- 37.
  • Bystryn JC. How should pemphigus be treated? J Eur Acad Dermatol Venereol 2002;16(4):562-3.
  • Mutasim DF. Management of autoimmune bullous diseases: pharmacology and therapeutics. J Am Acad Dermatol 2004;51:859-77.
  • Korman NJ. New immunomodulating drugs in autoimmune blistering diseases. Dermatol Clin 2001;19(1):37-48.
  • Scully C, Challacombe SJ. Pemphigus vulgaris: up- date on etiopathogenesis, oral manifestations, and management. Crit Rev Oral Biol Med 2002;13(4):397- 408.
  • El Tal AK, Posner MR, Spigelman Z, Ahmed AR. Rituximab: a monoclonal antibody to CD20 used in the treatment of pemphigus vulgaris. J Am Acad Der- matol 2006;55(3):449-59.

Pemfigus

Yıl 2011, , 468 - 473, 01.12.2011
https://doi.org/10.5799/ahinjs.01.2011.04.0099

Öz

Pemfigus deri ve mükoz membranların büllöz, sık görülmeyen otoimmün kökenli bir hastalığıdır. Hastalığın patogenezinde keratinosit yüzeyindeki proteinlere karşı gelişen otoantikorların önemli rolü mevcuttur. Pemfigusun insidansı hastalığın tipine göre ülkeden ülkeye değişiklik gösterir. Pemfigus vulgaris tüm pemfigusluların yaklaşık %80\'nini oluşturmaktadır ve pemfigus foliaseustan 10 kat daha fazla gözlenmektedir. Tedavide başta sistemik glukokortikoidler olmak üzere çeşitli immünsupresifler kullanılmaktadır ve son yıllarda yeni tedavi ajanları geliştirilmiştir. Bu derlemede pemfigus epidemiyolojisi, patogenezi, kliniği ve tedavisi güncel bilgiler ışığında gözden geçirilmiştir.

Kaynakça

  • Stanley JR. Pemphigus. In: Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, Eds. Fitz- patrick’s Dermatology in General Medicine. 6th Ed, New York: McGraw-Hill Company 2003:558-67.
  • Amagai M. Vesiculobullous diseases, Pemphigus: In Dermatology. Bolognia JL, Jorizzo JL, Rapini RP 2nd Ed, London: Mosby, 2008;31:417-29.
  • Heng A, Nwanneshıudu A, Hashimoto T. Intraepidermal neutrophilic IgA/IgG antidesmocollin 1 pemphigus. Brit J Dermatol 2006;154(8):1018-9.
  • Uzun S, Durdu M, Akman A, et al. Pemphigus in the Mediterranean region of Turkey: A study of 148 cases. Int J Dermatol 2006;45(4):523-8.
  • Odom RB, James WD, Berger TG. Andrew’s Diseases of the Skin. 9th Ed, Philadelphia: WB Saunders Com- pany 2000:574-605.
  • Ruocco E, Aurilia A, Ruocco V. Precautions and Suggestions for Pemphigus patients. Dermatology 2001;203(2):201-7.
  • Wucherpfennig KW, Yu B, Bhol K, Monos SD, et al. Structural basis for major histocompatibility complex (MHC).-linked susceptibility to autoimmunity: charged residues of a single MHC binding pocket confer se- lective presentation of self-peptides in pemphigus vul- garis. Proc Natl Acad Sci USA 1995;92(22):11935-9.
  • Uzun S. Büllü hastalıklar. Dermatoloji’de. Tüzün Y, Gü- rer MA, Serdaroğlu S, Oğuz O, Aksungur VL, ed. 3. baskı. İstanbul Nobel Tıp Kitabevi, 2008:807-32.
  • Brenner S, Sason A, Sharon O. Pemphigus and Infec- tions. Clin Dermatol 2002;20(1):114-8.
  • Udey MC, Stanley JR. Pemphigus-Diseases of Antides- mosomal Autoimmunity. JAMA 1999;282(6):572-6.
  • Braun-Falco O, Plewig G, Wolff HH, Burgdorf WHC. Dermatology. 2nd Ed, Berlin:Springer-Verlag 2000;649- 95.
  • Nguyen VT, Ndoye A, Grando SA. Pemphigus vulgar- is antibody identifies pemphaxin. A novel keratinocyte annexin-like molecule binding acetylcholine. J Biol Chem 2000;275(38):29466-76.
  • Amagai M. Autoimmunity against desmosomal cad- herins in pemphigus. J Dermatol Sci 1999;20(2):92- 102.
  • Ishii N, Ishida-Yamamoto A, Hashimoto T. Immuno- localization of target autoantigens in IgA pemphigus. Clin Exp Dermatol 2004;29(1):62-6.
  • V’lckova-Laskosa MT, Laskosi DS, Kamberova S, Ca- ca-Biljanovska N, Volckova N. Epidemiology of pem- phigus in Macedonia: A 15-year retrospective study 1990-2004. Int J Dermatol 2007;46(2):253-8.
  • Cohen LM, Skopicki DK, Harrist TJ, Clark WH. Non- infectious Vesiculobullous and Vesiculopustular Dis- eases. In: Elder D, Elenitsas R, Jaworsky C, Johnson B, Eds. Lever’s Histopathology of the Skin. 8th Ed, Philadelphia: Lippincott-Raven 1997:209-52.
  • Bystryn JC, Rudolph JL. Pemphigus. Lancet 2005;366(25):61-73.
  • Uzun S. Otoimmün büllöz hastalıklarda laboratuar tanı. Dermatose 2002;2(1):42-6.
  • Turgutalp SÇ, Harman M. Pemfigusta Seyir ve Prog- noz: 42 hastanın değerlendirilmesi. Dicle Tıp Dergisi 2008;35(1):29-31.
  • Yeh SW, Ahmed B, Sami N, Razzaque A. Blistering disorders: diagnosis and treatment. Dermatol Ther 2003;16(3):214-23.
  • Fellner MJ, Sapadin AN. Current therapy of pemphi- gus vulgaris. Mt Sinai J Med 2001; 68(4-5):268-78.
  • Harman KE, Albert S, Black MM; British Association of Dermatologists. Guidelines for the management of pemphigus vulgaris. Br J Dermatol 2003;149(8):926- 37.
  • Bystryn JC. How should pemphigus be treated? J Eur Acad Dermatol Venereol 2002;16(4):562-3.
  • Mutasim DF. Management of autoimmune bullous diseases: pharmacology and therapeutics. J Am Acad Dermatol 2004;51:859-77.
  • Korman NJ. New immunomodulating drugs in autoimmune blistering diseases. Dermatol Clin 2001;19(1):37-48.
  • Scully C, Challacombe SJ. Pemphigus vulgaris: up- date on etiopathogenesis, oral manifestations, and management. Crit Rev Oral Biol Med 2002;13(4):397- 408.
  • El Tal AK, Posner MR, Spigelman Z, Ahmed AR. Rituximab: a monoclonal antibody to CD20 used in the treatment of pemphigus vulgaris. J Am Acad Der- matol 2006;55(3):449-59.
Toplam 27 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Derleme
Yazarlar

Derya Uçmak Bu kişi benim

Yayımlanma Tarihi 1 Aralık 2011
Yayımlandığı Sayı Yıl 2011

Kaynak Göster

APA Uçmak, D. (2011). Pemfigus. Journal of Clinical and Experimental Investigations, 2(4), 468-473. https://doi.org/10.5799/ahinjs.01.2011.04.0099
AMA Uçmak D. Pemfigus. J Clin Exp Invest. Aralık 2011;2(4):468-473. doi:10.5799/ahinjs.01.2011.04.0099
Chicago Uçmak, Derya. “Pemfigus”. Journal of Clinical and Experimental Investigations 2, sy. 4 (Aralık 2011): 468-73. https://doi.org/10.5799/ahinjs.01.2011.04.0099.
EndNote Uçmak D (01 Aralık 2011) Pemfigus. Journal of Clinical and Experimental Investigations 2 4 468–473.
IEEE D. Uçmak, “Pemfigus”, J Clin Exp Invest, c. 2, sy. 4, ss. 468–473, 2011, doi: 10.5799/ahinjs.01.2011.04.0099.
ISNAD Uçmak, Derya. “Pemfigus”. Journal of Clinical and Experimental Investigations 2/4 (Aralık 2011), 468-473. https://doi.org/10.5799/ahinjs.01.2011.04.0099.
JAMA Uçmak D. Pemfigus. J Clin Exp Invest. 2011;2:468–473.
MLA Uçmak, Derya. “Pemfigus”. Journal of Clinical and Experimental Investigations, c. 2, sy. 4, 2011, ss. 468-73, doi:10.5799/ahinjs.01.2011.04.0099.
Vancouver Uçmak D. Pemfigus. J Clin Exp Invest. 2011;2(4):468-73.