BibTex RIS Kaynak Göster

A general evaluation on pulmonary nocardiosis due to three patients presenting with a mass like radiographic appearance on chest X-ray

Yıl 2010, , 219 - 225, 01.09.2010
https://doi.org/10.5799/ahinjs.01.2010.03.0046

Öz

Pulmonary nocardiosis is an important cause of opportunistic infection in immune-compromised patients. Pulmonary nocardiosis manifests as an acute, subacute or chronic infection. Although, there is specific treatment, there are usually difficulties in its diagnosis and, therefore nocardiosis already has a high rate of mortality. All of the nocardia infections of our study were pulmonary nocardiosis. The first case of our study was receiving immunosuppressive drugs after renal transplantation; second patient was receiving high dose corticosteroid and methotrexate due to the systemic lupus erithematosus; and third patient was newly diagnosed acute renal failure. All the diagnosis of pulmonary nocardiosis was done by isolation of the organism from bronchial lavage fluids. All patients were healed and discharged. The duration of therapy was 12 months in the first patients, 2 months in the second and 3 months in the third patient. According to results of our cases we concluded that nocardia tends to affect patients with cellular immune-compromised, physicians should notify the laboratory staff when Nocardia is suspected and the duration of therapy depends on the severity and the host\'s immune status.

Kaynakça

  • Martinez R, Reyesa S, Menendez R., Pulmonary nocardiosis: risk factors, clinical features, diagnosis and prognosis. Curr Opin Pulm Med 2008;14:219–27.
  • Arduino RC, Johnson PC, Miranda AG: Nocardiosis in renal transplant recipients undergoing immunosuppression with cyclosporine. Clin Infect Dis 1993;16:505–12.
  • Van Burik JA, Hackman RC, Nadeem SQ, et al: Nocardiosis after bone marrow transplantation: A retrospective study. Clin Infect Dis 1997;24:1154–60.
  • Saubolle MA, Sussland D. Nocardiosis: review of clini- cal and laboratory experience. J Clin Microbiol 2003; 41:4497–501.
  • Menendez R, Cordero PJ, Santos M, et al. Pulmonary infec- tion with Nocardia species: a report of 10 cases and review. Eur Respir J 1997; 10:1542–6.
  • Martinez TR, Menendez VR, Reyes CS, et al. Pulmonary nocardiosis: risk factors and outcomes. Respirology 2007; 12:394–400.
  • Oszoyoglu AA, Kirsch J, Mohammed TL. Pulmonary no- cardiosis after lung transplantation: CT findings in 7 pa- tients and review of the literature. J Thorac Imaging 2007; 22:143–8.
  • Peleg AY, Husain S, Qureshi ZA, et al. Risk factors, clinical characteristics, and outcome of Nocardia infection in organ transplant recipients: a matched case–control study. Clin Infect Dis 2007; 44:1307–1314.
  • Munoz J, Mirelis B, Aragon LM, et al. Clinical and micro- biological features of nocardiosis. J Med Microbiol 2007; 56:545–50.
  • Castro JG, Espinoza L. Nocardia species infections in a large county hospital in Miami: 6 years experience. J Infect 2007; 54:358–61.
  • Brown-Elliot BA, Brown JM, Conville PS,Wallace RJ Jr. Clinical and laboratory features of the Nocardia spp. based on current molecular taxonomy. Clin Microbiol Rev 2006; 19:259–82.
  • Mootsikapun P, Intarapoka B, Liawnoraset W. Nocardiosis in Srinagarind Hospital, Thailand: review of 70 cases from 1996–2001. Int J Infect Dis 2005; 9:154–158.
  • Hitti W,Wolff M. Two cases of multidrug-resistant Nocardia farcinica infection in immunosuppressed patients and im- plications for empiric therapy. Eur J Clin Microbiol Infect Dis 2005; 24:142–4.
  • Yildiz O, Doganay M. Actinomycoses and Nocardia pulmo- nary infections. Curr Opin Pulm Med 2006; 12:228–34.
  • Gombert ME, Aulicino TM, duBouchet L, et al. Therapy of experimental cerebral nocardiosis with imipenem, ami- kacin, trimethoprim-sulfamethoxazole, and minocycline. Antimicrob Agents Chemother 1986; 30:270–3.
  • Khardori N, Shawar R, Gupta R, et al. In vitro antimicrobial susceptibilities of Nocardia species. Antimicrob Agents Chemother 1993; 37:882–4.

A general evaluation on pulmonary nocardiosis due to three patients presenting with a mass like radiographic appearance on chest X-ray

Yıl 2010, , 219 - 225, 01.09.2010
https://doi.org/10.5799/ahinjs.01.2010.03.0046

Öz

Akciğer nokardiyozisi, immun düşkün hastalarda görülen önemli bir fırsatçı enfeksiyondur. Nocardia türleri tarafından oluşturulan bu enfeksiyon akut, subakut ve kronik hastalık olarak karşımıza çıkabilir. Spesifik tedavisi olmasına rağmen tanısındaki güçlükler nedeniyle mortalitesi yüksek bir enfeksiyondur. Bizim çalışmamızdaki nokardiya olgularının tamamı akciğer nokardiyozisi şeklinde idi. Olgularımızdan birincisi bir yıldır immun süpresif tedavi gören renal transplant alıcısı, ikincisi sistemik lupus eritematozus nedeniyle uzun süredir yüksek doz kortikosteroid ve metotreksat kullanıyordu, üçüncüsü ise yeni tanı almış kronik böbrek yetmezlikli idi. Çalışmamızda tüm hastaların mikrobiyolojik tanıları bronkoalveoler yıkamada nokardiya türlerinin izole edilmesi ile konuldu. Hastaların tümü hastaneden iyileşerek taburcu edildi. Bir hastada tedavi süresi 12 ay, bir tanesinde 2 ay, diğer hastada ise 3 ay sürdü. Olgularımızdan elde edilen bulgular ışığında akciğer nokardiyozisi ile ilgili olarak şu sonuçlara ulaşıldı; Nokardiyozis özellikle hücresel immunitesi baskılanmış hastalarda düşünülmelidir, nokardiya şüphesi oluştuğunda bu bilgi laboratuvara iletilmeli ve tedavi süresi hastalığın ağırlığı ve radyolojik cevaba göre düzenlenmelidir.

Kaynakça

  • Martinez R, Reyesa S, Menendez R., Pulmonary nocardiosis: risk factors, clinical features, diagnosis and prognosis. Curr Opin Pulm Med 2008;14:219–27.
  • Arduino RC, Johnson PC, Miranda AG: Nocardiosis in renal transplant recipients undergoing immunosuppression with cyclosporine. Clin Infect Dis 1993;16:505–12.
  • Van Burik JA, Hackman RC, Nadeem SQ, et al: Nocardiosis after bone marrow transplantation: A retrospective study. Clin Infect Dis 1997;24:1154–60.
  • Saubolle MA, Sussland D. Nocardiosis: review of clini- cal and laboratory experience. J Clin Microbiol 2003; 41:4497–501.
  • Menendez R, Cordero PJ, Santos M, et al. Pulmonary infec- tion with Nocardia species: a report of 10 cases and review. Eur Respir J 1997; 10:1542–6.
  • Martinez TR, Menendez VR, Reyes CS, et al. Pulmonary nocardiosis: risk factors and outcomes. Respirology 2007; 12:394–400.
  • Oszoyoglu AA, Kirsch J, Mohammed TL. Pulmonary no- cardiosis after lung transplantation: CT findings in 7 pa- tients and review of the literature. J Thorac Imaging 2007; 22:143–8.
  • Peleg AY, Husain S, Qureshi ZA, et al. Risk factors, clinical characteristics, and outcome of Nocardia infection in organ transplant recipients: a matched case–control study. Clin Infect Dis 2007; 44:1307–1314.
  • Munoz J, Mirelis B, Aragon LM, et al. Clinical and micro- biological features of nocardiosis. J Med Microbiol 2007; 56:545–50.
  • Castro JG, Espinoza L. Nocardia species infections in a large county hospital in Miami: 6 years experience. J Infect 2007; 54:358–61.
  • Brown-Elliot BA, Brown JM, Conville PS,Wallace RJ Jr. Clinical and laboratory features of the Nocardia spp. based on current molecular taxonomy. Clin Microbiol Rev 2006; 19:259–82.
  • Mootsikapun P, Intarapoka B, Liawnoraset W. Nocardiosis in Srinagarind Hospital, Thailand: review of 70 cases from 1996–2001. Int J Infect Dis 2005; 9:154–158.
  • Hitti W,Wolff M. Two cases of multidrug-resistant Nocardia farcinica infection in immunosuppressed patients and im- plications for empiric therapy. Eur J Clin Microbiol Infect Dis 2005; 24:142–4.
  • Yildiz O, Doganay M. Actinomycoses and Nocardia pulmo- nary infections. Curr Opin Pulm Med 2006; 12:228–34.
  • Gombert ME, Aulicino TM, duBouchet L, et al. Therapy of experimental cerebral nocardiosis with imipenem, ami- kacin, trimethoprim-sulfamethoxazole, and minocycline. Antimicrob Agents Chemother 1986; 30:270–3.
  • Khardori N, Shawar R, Gupta R, et al. In vitro antimicrobial susceptibilities of Nocardia species. Antimicrob Agents Chemother 1993; 37:882–4.
Toplam 16 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Olgu Sunumu
Yazarlar

İrfan Uçgun Bu kişi benim

Füsun Alataş Bu kişi benim

Bengü Doğan Bu kişi benim

Yayımlanma Tarihi 1 Eylül 2010
Yayımlandığı Sayı Yıl 2010

Kaynak Göster

APA Uçgun, İ., Alataş, F., & Doğan, B. (2010). A general evaluation on pulmonary nocardiosis due to three patients presenting with a mass like radiographic appearance on chest X-ray. Journal of Clinical and Experimental Investigations, 1(3), 219-225. https://doi.org/10.5799/ahinjs.01.2010.03.0046
AMA Uçgun İ, Alataş F, Doğan B. A general evaluation on pulmonary nocardiosis due to three patients presenting with a mass like radiographic appearance on chest X-ray. J Clin Exp Invest. Eylül 2010;1(3):219-225. doi:10.5799/ahinjs.01.2010.03.0046
Chicago Uçgun, İrfan, Füsun Alataş, ve Bengü Doğan. “A General Evaluation on Pulmonary Nocardiosis Due to Three Patients Presenting With a Mass Like Radiographic Appearance on Chest X-Ray”. Journal of Clinical and Experimental Investigations 1, sy. 3 (Eylül 2010): 219-25. https://doi.org/10.5799/ahinjs.01.2010.03.0046.
EndNote Uçgun İ, Alataş F, Doğan B (01 Eylül 2010) A general evaluation on pulmonary nocardiosis due to three patients presenting with a mass like radiographic appearance on chest X-ray. Journal of Clinical and Experimental Investigations 1 3 219–225.
IEEE İ. Uçgun, F. Alataş, ve B. Doğan, “A general evaluation on pulmonary nocardiosis due to three patients presenting with a mass like radiographic appearance on chest X-ray”, J Clin Exp Invest, c. 1, sy. 3, ss. 219–225, 2010, doi: 10.5799/ahinjs.01.2010.03.0046.
ISNAD Uçgun, İrfan vd. “A General Evaluation on Pulmonary Nocardiosis Due to Three Patients Presenting With a Mass Like Radiographic Appearance on Chest X-Ray”. Journal of Clinical and Experimental Investigations 1/3 (Eylül 2010), 219-225. https://doi.org/10.5799/ahinjs.01.2010.03.0046.
JAMA Uçgun İ, Alataş F, Doğan B. A general evaluation on pulmonary nocardiosis due to three patients presenting with a mass like radiographic appearance on chest X-ray. J Clin Exp Invest. 2010;1:219–225.
MLA Uçgun, İrfan vd. “A General Evaluation on Pulmonary Nocardiosis Due to Three Patients Presenting With a Mass Like Radiographic Appearance on Chest X-Ray”. Journal of Clinical and Experimental Investigations, c. 1, sy. 3, 2010, ss. 219-25, doi:10.5799/ahinjs.01.2010.03.0046.
Vancouver Uçgun İ, Alataş F, Doğan B. A general evaluation on pulmonary nocardiosis due to three patients presenting with a mass like radiographic appearance on chest X-ray. J Clin Exp Invest. 2010;1(3):219-25.