Evaluation of the metabolic characteristics of patients with Acromegaly

Cilt: 6 Sayı: 4 3 Ocak 2016
  • Faruk Kılınç
  • Zafer Pekkolay
  • Nevzat Gözel
  • Hikmet Soylu
  • Ahmet Yılmaz
  • Yaşar Yıldırım
  • Fatih Şahpaz
  • Alpaslan Tuzcu
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Evaluation of the metabolic characteristics of patients with Acromegaly

Öz

Objective: Acromegaly is a syndrome characterized by growth hormone (GH) and insulin like growth factor-1 (IGF-1) over secretion. It was aimed to sharing detected metabolic disorders of the patients with acromegaly who have been under follow-up at our clinic.

Methods: One hundred five patients, who were diagnosed as acromegaly in our clinic between 2010 and 2015, were enrolled to the study. The age, gender, involvement feature additional systemic and metabolic diseases were recorded and laboratory findings.

Results: A total of 105 patients included in the study, 56 women (53.3%) and 49 men (46.7%), respectively. Patient’s’ ages ranged 23-78 (mean 42.1±16.7). 34 patients (32.3%), hypertension in 20 (19.04%), diabetes mellitus, and is 11 (10.4%) had impaired glucose tolerance.

Conclusion: Somatic disfigurement (hand and foot enlargement etc.) is the major characteristic of the disease but the prognosis is determined by cardiovascular, respiratory and metabolic complications. In acromegaly, hypertension and diabetes are common, cardiovascular disease is the principal cause of death. We believe that our study will contribute to the determination of our country’s data. J Clin Exp Invest 2015; 6 (4): 382-386

Key words: Acromegaly, hypertension, diabetes

Anahtar Kelimeler

Kaynakça

  1. Melmed S. Medical progress: Acromegaly. N Engl J Med 2006;355:2558-2565.
  2. Thorner MO, LeeVance M, Laws ER Jr, et al. The anterior
  3. pituitary. W Textbook of Endocrinol 1998;128:249-340.
  4. Acromegaly: Epidemiology, etiology and classification in: Acromegaly and its management In: Haris AG. Lipp Raven NY 1996;22:17-20.
  5. Ho KY, WeisSberger AJ. Characterisation of 24 hour GH secretion in acromegaly: Implications for diagnosis and therapy. Clin Endocrinol 1994;41:75-83.
  6. Baumann G. Growth hormone and its disorders. I: Principles
  7. and Practices of Endocrinology and Metabolism, In: Becker KL, ed. Lipincott Williams & Wilkins 2001;20:129-145.
  8. Melmed S. Acromegaly. NEJM 1990;322:966-977.

Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

-

Yazarlar

Faruk Kılınç Bu kişi benim

Zafer Pekkolay Bu kişi benim

Nevzat Gözel Bu kişi benim

Hikmet Soylu Bu kişi benim

Ahmet Yılmaz Bu kişi benim

Yaşar Yıldırım Bu kişi benim

Fatih Şahpaz Bu kişi benim

Alpaslan Tuzcu Bu kişi benim

Yayımlanma Tarihi

3 Ocak 2016

Gönderilme Tarihi

3 Ocak 2016

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2015 Cilt: 6 Sayı: 4

Kaynak Göster

APA
Kılınç, F., Pekkolay, Z., Gözel, N., Soylu, H., Yılmaz, A., Yıldırım, Y., Şahpaz, F., & Tuzcu, A. (2016). Evaluation of the metabolic characteristics of patients with Acromegaly. Journal of Clinical and Experimental Investigations, 6(4), 382-386. https://doi.org/10.5799/ahinjs.01.2015.04.0553
AMA
1.Kılınç F, Pekkolay Z, Gözel N, vd. Evaluation of the metabolic characteristics of patients with Acromegaly. J Clin Exp Invest. 2016;6(4):382-386. doi:10.5799/ahinjs.01.2015.04.0553
Chicago
Kılınç, Faruk, Zafer Pekkolay, Nevzat Gözel, vd. 2016. “Evaluation of the metabolic characteristics of patients with Acromegaly”. Journal of Clinical and Experimental Investigations 6 (4): 382-86. https://doi.org/10.5799/ahinjs.01.2015.04.0553.
EndNote
Kılınç F, Pekkolay Z, Gözel N, Soylu H, Yılmaz A, Yıldırım Y, Şahpaz F, Tuzcu A (01 Ocak 2016) Evaluation of the metabolic characteristics of patients with Acromegaly. Journal of Clinical and Experimental Investigations 6 4 382–386.
IEEE
[1]F. Kılınç vd., “Evaluation of the metabolic characteristics of patients with Acromegaly”, J Clin Exp Invest, c. 6, sy 4, ss. 382–386, Oca. 2016, doi: 10.5799/ahinjs.01.2015.04.0553.
ISNAD
Kılınç, Faruk - Pekkolay, Zafer - Gözel, Nevzat - Soylu, Hikmet - Yılmaz, Ahmet - Yıldırım, Yaşar - Şahpaz, Fatih - Tuzcu, Alpaslan. “Evaluation of the metabolic characteristics of patients with Acromegaly”. Journal of Clinical and Experimental Investigations 6/4 (01 Ocak 2016): 382-386. https://doi.org/10.5799/ahinjs.01.2015.04.0553.
JAMA
1.Kılınç F, Pekkolay Z, Gözel N, Soylu H, Yılmaz A, Yıldırım Y, Şahpaz F, Tuzcu A. Evaluation of the metabolic characteristics of patients with Acromegaly. J Clin Exp Invest. 2016;6:382–386.
MLA
Kılınç, Faruk, vd. “Evaluation of the metabolic characteristics of patients with Acromegaly”. Journal of Clinical and Experimental Investigations, c. 6, sy 4, Ocak 2016, ss. 382-6, doi:10.5799/ahinjs.01.2015.04.0553.
Vancouver
1.Faruk Kılınç, Zafer Pekkolay, Nevzat Gözel, Hikmet Soylu, Ahmet Yılmaz, Yaşar Yıldırım, Fatih Şahpaz, Alpaslan Tuzcu. Evaluation of the metabolic characteristics of patients with Acromegaly. J Clin Exp Invest. 01 Ocak 2016;6(4):382-6. doi:10.5799/ahinjs.01.2015.04.0553