Evaluation of the metabolic characteristics of patients with Acromegaly
Öz
Objective: Acromegaly is a syndrome characterized by growth hormone (GH) and insulin like growth factor-1 (IGF-1) over secretion. It was aimed to sharing detected metabolic disorders of the patients with acromegaly who have been under follow-up at our clinic.
Methods: One hundred five patients, who were diagnosed as acromegaly in our clinic between 2010 and 2015, were enrolled to the study. The age, gender, involvement feature additional systemic and metabolic diseases were recorded and laboratory findings.
Results: A total of 105 patients included in the study, 56 women (53.3%) and 49 men (46.7%), respectively. Patient’s’ ages ranged 23-78 (mean 42.1±16.7). 34 patients (32.3%), hypertension in 20 (19.04%), diabetes mellitus, and is 11 (10.4%) had impaired glucose tolerance.
Conclusion: Somatic disfigurement (hand and foot enlargement etc.) is the major characteristic of the disease but the prognosis is determined by cardiovascular, respiratory and metabolic complications. In acromegaly, hypertension and diabetes are common, cardiovascular disease is the principal cause of death. We believe that our study will contribute to the determination of our country’s data. J Clin Exp Invest 2015; 6 (4): 382-386
Key words: Acromegaly, hypertension, diabetes
Anahtar Kelimeler
Kaynakça
- Melmed S. Medical progress: Acromegaly. N Engl J Med 2006;355:2558-2565.
- Thorner MO, LeeVance M, Laws ER Jr, et al. The anterior
- pituitary. W Textbook of Endocrinol 1998;128:249-340.
- Acromegaly: Epidemiology, etiology and classification in: Acromegaly and its management In: Haris AG. Lipp Raven NY 1996;22:17-20.
- Ho KY, WeisSberger AJ. Characterisation of 24 hour GH secretion in acromegaly: Implications for diagnosis and therapy. Clin Endocrinol 1994;41:75-83.
- Baumann G. Growth hormone and its disorders. I: Principles
- and Practices of Endocrinology and Metabolism, In: Becker KL, ed. Lipincott Williams & Wilkins 2001;20:129-145.
- Melmed S. Acromegaly. NEJM 1990;322:966-977.
Ayrıntılar
Birincil Dil
Türkçe
Konular
-
Bölüm
-
Yazarlar
Faruk Kılınç
Bu kişi benim
Zafer Pekkolay
Bu kişi benim
Nevzat Gözel
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Hikmet Soylu
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Ahmet Yılmaz
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Yaşar Yıldırım
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Fatih Şahpaz
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Alpaslan Tuzcu
Bu kişi benim
Yayımlanma Tarihi
3 Ocak 2016
Gönderilme Tarihi
3 Ocak 2016
Kabul Tarihi
-
Yayımlandığı Sayı
Yıl 2015 Cilt: 6 Sayı: 4