Araştırma Makalesi
BibTex RIS Kaynak Göster

Evaluation of TNFRSF11B Gene Polymorphism in Patients with Acute Stroke

Yıl 2016, , 184 - 189, 16.06.2016
https://doi.org/10.5799/ahinjs.01.2016.02.0594

Öz


Objective: Tumor necrosis factor receptor superfamily,
member 11b (TNFRSF11B) has been suggested to be a risk fac­tor for
atherosclerosis and cardiovascular diseases because of the observation
of osteoporosis and vascular diseases together in human, and the high
levels of serum TNFRSF11B in these patients in clinical trials. In this
study, we aimed to investigate the association between TNFRSF11B gene
1181G˃C polymorphism and acute stroke as a cerebrovascular disease.


Methods: In this study, the DNAs of 107 acute stroke
patients and 100 healthy controls have been analyzed by poly­merase
chain reaction (PCR) and restriction fragment length polymorphism
(RFLP). Statistical analyses were performed by using chi-square and
analysis of variance tests.


Results: When we compared the genotype and allele
frequencies of patients and controls, any statistically significant
differences was not found between them (p=0.476 and p=0.622,
respectively). Any association also was not observed when demographical
and clinical characteristics of patients was compared with TNFRSF11B
gene 1181G˃C polymor­phism (p>0.05).


Conclusion: As a result, our findings showed that
there was no association between TNFRSF11B gene 1181G>C poly­morphism
and acute stroke. However, further studies can reveal more clearly
whether there is a relationship between TNFRSF11B gene polymorphism and
acute stroke in Turkish population.

Kaynakça

  • 1. Allan H, Ropper RHB. Adams and Victor’s Principles of Neurology, 8 th edn. New York: McGraw-Hill, 2005:660. 2. Rosamond W, Flegal K, Furie K, et al. Heart disease and stroke statistics-2008 update: a report from the American Heart Association Statistics Committee and Stroke Statis - tics Subcommittee. Circulation. 2008;117:e25-146. 3. Ayala C, Croft JB, Greenlund KJ, et al. Sex differences in US mortality rates for stroke and stroke subtypes by race/ ethnicity and age,1995-1998. Stroke. 2002;33:1197- 1201. 4. Adams RD, Victor M. Ropper AH. Principles of Neurology, 6 th edn. USA: Mc Graw Hill,1997:777-873. 5. Schoppet M, Preissner KT, Hofbauer LC. RANK ligand and osteoprotegerin: paracrine regulators of bone metabolism and vascular function. Arterioscler Thromb Vasc Biol. 2002;22:549. 6. Brendan FB, Lianping X. Biology of RANK, RANKL and osteoprotogerin. Arthritis Research &Therapy. 2007;9:1-7. 7. Fata JE, Kong YY, Li J, et al. The Osteoclast differentia - tion factor osteoprotegerin-ligand is essential for mammary gland development. Cell. 2000;103:41-50. 8. Kim NS, Kim HJ, Koo BK, et al. Receptor activator of NF kapa B ligand regulates the proliferation of mammary epi - thelial cells via Id2. Mol Cell Biol. 2006;26:1002-13. 9. Chen G, Sircar K, Aprikian A, et al. Expression of RANK L/RANK/OPG in primary and metastatic human prostate cancer as markers of disease stage and functional regula - tion. Cancer. 2006;107:289-98. 10. Suda T. Modulation of osteoclast differentiation and func - tion by the new members of the tumor necrosis factor re - ceptor and ligand families. Endocr Rev. 1999;20:345-57. 11. Kong YY. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 1999;397:315-323. 12. Blair JM, Zheng Y, Dunstan CR. RANK ligand. Int J Bio - chem Cell Biol. 2007;39:1077-81. 13. Luckish A, Cernes R, Boaz M, et al. Effect of long-term treatment with risedronate on arterial compliance in os - teoporotic patient with cardiovascular risk factors. Bone. 2008;43:279-283. 14. Rumianowska A, Nehring P, Mrozikiewicz-Rakowska B, et al. Osteoprotegerin - a new marker of the atherosclerosis helpful in selecting patients at amputation risk? Leczenie Ran. 2011;8:1-5. 15. Jeffcoate WJ, Rasmussen LM, Hofbauer LC, Game FL. Medial arteria calcification in diabetes and its relationship to neuropathy. Diabetologia 2009;52:2478-88. 16. Biscetti F, Straface G, Giovannini S, et al. Association be - tween TNFRSF11B gene polymorphisms and history of ischemic stroke in Italian diabetic patients. Human Genet 2013;132:49-55. 17. Seremak-Mrozikiewicz A, Barlik M, Drews K, et al. The genetic variants of RANKL/RANK/OPG signal trial in postmenopausal women with osteopenia and osteoporosis. Arch Perinat Med. 2011;17:72-80. 18. Soufi M, SchoppetM, Sattler A, et al. Osteoprotegerin gene polymorphisms in men with coronary artery disease. J Clin Endocrinol Metab. 2004;89:3764-8. 19. Mrozikiewicz A, Barlık M, Drews K, et al. The genetic vari - ants of RANKL\RANK\OPG signal trial in postmenopaus - al women with ostepenia and osteoporosis. Arch Perinat Med. 2011;17:72-8. 20. Straface G, Biscetti F, Pitoco D, et al. Assessment of the genetic effects of polymorphism in the osteoprotegerin gene,TNFRSF11B, on serum osteoprotegerin levels and carotid plaque vulnerability. Stroke. 2011;24:3022-8.
Yıl 2016, , 184 - 189, 16.06.2016
https://doi.org/10.5799/ahinjs.01.2016.02.0594

Öz

Kaynakça

  • 1. Allan H, Ropper RHB. Adams and Victor’s Principles of Neurology, 8 th edn. New York: McGraw-Hill, 2005:660. 2. Rosamond W, Flegal K, Furie K, et al. Heart disease and stroke statistics-2008 update: a report from the American Heart Association Statistics Committee and Stroke Statis - tics Subcommittee. Circulation. 2008;117:e25-146. 3. Ayala C, Croft JB, Greenlund KJ, et al. Sex differences in US mortality rates for stroke and stroke subtypes by race/ ethnicity and age,1995-1998. Stroke. 2002;33:1197- 1201. 4. Adams RD, Victor M. Ropper AH. Principles of Neurology, 6 th edn. USA: Mc Graw Hill,1997:777-873. 5. Schoppet M, Preissner KT, Hofbauer LC. RANK ligand and osteoprotegerin: paracrine regulators of bone metabolism and vascular function. Arterioscler Thromb Vasc Biol. 2002;22:549. 6. Brendan FB, Lianping X. Biology of RANK, RANKL and osteoprotogerin. Arthritis Research &Therapy. 2007;9:1-7. 7. Fata JE, Kong YY, Li J, et al. The Osteoclast differentia - tion factor osteoprotegerin-ligand is essential for mammary gland development. Cell. 2000;103:41-50. 8. Kim NS, Kim HJ, Koo BK, et al. Receptor activator of NF kapa B ligand regulates the proliferation of mammary epi - thelial cells via Id2. Mol Cell Biol. 2006;26:1002-13. 9. Chen G, Sircar K, Aprikian A, et al. Expression of RANK L/RANK/OPG in primary and metastatic human prostate cancer as markers of disease stage and functional regula - tion. Cancer. 2006;107:289-98. 10. Suda T. Modulation of osteoclast differentiation and func - tion by the new members of the tumor necrosis factor re - ceptor and ligand families. Endocr Rev. 1999;20:345-57. 11. Kong YY. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 1999;397:315-323. 12. Blair JM, Zheng Y, Dunstan CR. RANK ligand. Int J Bio - chem Cell Biol. 2007;39:1077-81. 13. Luckish A, Cernes R, Boaz M, et al. Effect of long-term treatment with risedronate on arterial compliance in os - teoporotic patient with cardiovascular risk factors. Bone. 2008;43:279-283. 14. Rumianowska A, Nehring P, Mrozikiewicz-Rakowska B, et al. Osteoprotegerin - a new marker of the atherosclerosis helpful in selecting patients at amputation risk? Leczenie Ran. 2011;8:1-5. 15. Jeffcoate WJ, Rasmussen LM, Hofbauer LC, Game FL. Medial arteria calcification in diabetes and its relationship to neuropathy. Diabetologia 2009;52:2478-88. 16. Biscetti F, Straface G, Giovannini S, et al. Association be - tween TNFRSF11B gene polymorphisms and history of ischemic stroke in Italian diabetic patients. Human Genet 2013;132:49-55. 17. Seremak-Mrozikiewicz A, Barlik M, Drews K, et al. The genetic variants of RANKL/RANK/OPG signal trial in postmenopausal women with osteopenia and osteoporosis. Arch Perinat Med. 2011;17:72-80. 18. Soufi M, SchoppetM, Sattler A, et al. Osteoprotegerin gene polymorphisms in men with coronary artery disease. J Clin Endocrinol Metab. 2004;89:3764-8. 19. Mrozikiewicz A, Barlık M, Drews K, et al. The genetic vari - ants of RANKL\RANK\OPG signal trial in postmenopaus - al women with ostepenia and osteoporosis. Arch Perinat Med. 2011;17:72-8. 20. Straface G, Biscetti F, Pitoco D, et al. Assessment of the genetic effects of polymorphism in the osteoprotegerin gene,TNFRSF11B, on serum osteoprotegerin levels and carotid plaque vulnerability. Stroke. 2011;24:3022-8.
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Konular Sağlık Kurumları Yönetimi
Bölüm Araştırma Yazısı
Yazarlar

Pınar Çoğaş Bu kişi benim

Yayımlanma Tarihi 16 Haziran 2016
Yayımlandığı Sayı Yıl 2016

Kaynak Göster

APA Çoğaş, P. (2016). Evaluation of TNFRSF11B Gene Polymorphism in Patients with Acute Stroke. Journal of Clinical and Experimental Investigations, 7(2), 184-189. https://doi.org/10.5799/ahinjs.01.2016.02.0594
AMA Çoğaş P. Evaluation of TNFRSF11B Gene Polymorphism in Patients with Acute Stroke. J Clin Exp Invest. Haziran 2016;7(2):184-189. doi:10.5799/ahinjs.01.2016.02.0594
Chicago Çoğaş, Pınar. “Evaluation of TNFRSF11B Gene Polymorphism in Patients With Acute Stroke”. Journal of Clinical and Experimental Investigations 7, sy. 2 (Haziran 2016): 184-89. https://doi.org/10.5799/ahinjs.01.2016.02.0594.
EndNote Çoğaş P (01 Haziran 2016) Evaluation of TNFRSF11B Gene Polymorphism in Patients with Acute Stroke. Journal of Clinical and Experimental Investigations 7 2 184–189.
IEEE P. Çoğaş, “Evaluation of TNFRSF11B Gene Polymorphism in Patients with Acute Stroke”, J Clin Exp Invest, c. 7, sy. 2, ss. 184–189, 2016, doi: 10.5799/ahinjs.01.2016.02.0594.
ISNAD Çoğaş, Pınar. “Evaluation of TNFRSF11B Gene Polymorphism in Patients With Acute Stroke”. Journal of Clinical and Experimental Investigations 7/2 (Haziran 2016), 184-189. https://doi.org/10.5799/ahinjs.01.2016.02.0594.
JAMA Çoğaş P. Evaluation of TNFRSF11B Gene Polymorphism in Patients with Acute Stroke. J Clin Exp Invest. 2016;7:184–189.
MLA Çoğaş, Pınar. “Evaluation of TNFRSF11B Gene Polymorphism in Patients With Acute Stroke”. Journal of Clinical and Experimental Investigations, c. 7, sy. 2, 2016, ss. 184-9, doi:10.5799/ahinjs.01.2016.02.0594.
Vancouver Çoğaş P. Evaluation of TNFRSF11B Gene Polymorphism in Patients with Acute Stroke. J Clin Exp Invest. 2016;7(2):184-9.