Araştırma Makalesi
BibTex RIS Kaynak Göster
Yıl 2017, , 76 - 84, 30.09.2017
https://doi.org/10.5799/jcei.343190

Öz

Kaynakça

  • 1. Amagase H, Farnsworth NR. A review of botanical characteristics, phytochemistry, clinical relevance in efficacy and safety of Lycium barbarum fruit (Goji). Food Res Int. 2011;44:1702-7.
  • 2. Bryan JK, Casta D, Giese N, Nummy K, Rapp C, Seamon E. Goji (Lyciumspp) in natural standard monograph. 2008. Natural Standard Inc.
  • 3. Dag S, Ozpinar H, Sari M, Ozpinar N. Antimicrobial effect of cola on several microorganisms. Cumhuriyet Sci J. 2015;36 52-9.
  • 4. Potterat O. Goji (Lycium barbarum and L. chinense): phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity. Planta Med. 2010;76 7-19.
  • 5. Fabricant DS, Farnsworth NR. The value of plants used in traditional medicine for drug discovery. Environ Health Perspect. 2001;109:69-78.
  • 6. Chan HC, Chang RCC, Ip AKC, et al. Neuroprotective effects of Lycium barbarum Lynn on protecting retinal ganglion cells in an ocular hypertension model of glaucoma. Expe Neurol. 2007;203:269-73.
  • 7. Chalasani SH, Chronis N, Tsunozaki M, Gray JM, Ramot D, Goodman MB, et al. Corrigendum: Dissecting a circuit for olfactory behaviour in Caenorhabditis elegans. Nature. 2016;533:130
  • 8. Ono K, Ono S. Two distinct myosin II populations coordinate ovulatory contraction of the myoepithelial sheath in the Caenorhabditis elegans somatic gonad. Mol Biol Ccell. 2016:27:1131-42.
  • 9. Ozpinar H, Ozpinar N, Kilicgun H, Dag S, Sari M. Physiological and lifespan alterations in Caenorhabditis elegans exposed to Benzoic acid. SSTB. 2011;7:39-47.
  • 10. Olgun A, Aleksenko T, Pereira-Smith OM, Vassilatis DK. Functional analysis of MRG-1: The ortholog of human MRG15 in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci. 2005;60:543-8.
  • 11. Turkoglu S. Genotoxicity of five food preservatives tested on root tips of Allium cepa L. Mutat Res Genet Toxicol Environ Mutagen. 2007;626:4- 14.
  • 12. Koelle MR, Horvitz HR. EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. Cell. 1996;84:115-25.
  • 13. Li X, Li X, Zhou A. Evaluation of antioxidant activity of the polysaccharides extracted from Lycium barbarum fruits in vitro. Eur Polym J. 2007;43:488-97.
  • 14. Lin CL, Wang CC, Chang SC, Inbaraj BS, Chen BH. Antioxidative activity of polysaccharide fractions isolated from Lycium barbarum Linnaeus. Int j biol Macromol. 2009;45:146-51.
  • 15. Wu SJ, Ng LT, Lin CC. Antioxidant activities of some common ingredients of traditional chinese medicine, Angelica sinensis, Lycium barbarum and Poria cocos. Phytother Res. 2004;18:1008-12.
  • 16. Chang RCC, So KF. Use of anti-aging herbal medicine, Lycium barbarum, against aging-associated diseases. What do we know so far?. Cell Mol Neurobiol. 2008;28:643-52.
  • 17. Gan L, Zhang SH, Yang XL, Xu HB. Immunomodulation and antitumor activity by a polysaccharide–protein complex from Lycium barbarum. Int Immunopharmacol. 2004;4:563-9.
  • 18. Li P, Xiao B, Chen H, Guo J. Lycium barbarum and tumors in the gastrointestinal tract, in Lycium barbarum and human health. 2015. Springer Netherlands, 2015. p. 85-97.
  • 19. Mao F, Xiao B, Jiang Z, Zhao J, Huang X, Guo J. Anticancer effect of Lycium barbarum polysaccharides on colon cancer cells involves G0/G1 phase arrest. Med Oncol. 2011;28:121-6.
  • 20. Yu MS, Lai CSW, Ho YS, Zee SY, So KF, Yuen WH, el al . Characterization of the effects of anti-aging medicine Fructus lycii on ß-amyloid peptide neurotoxicity. Int J Mol Med. 2007;20:261-8.
  • 21. Yu MS, Leung SKY, Lai SW, Che CM, Zee SY, So KF, et al. Neuroprotective effects of anti-aging oriental medicine Lycium barbarum against β-amyloid peptide neurotoxicity. Exp Gerontol. 2005;40:716-27.
  • 22. Yu MS, Ho YS, So KF, Yuen WH, Chang RCC. Cytoprotective effects of Lycium barbarum against reducing stress on endoplasmic reticulum. Int J Mol Med. 2006;17:1157-62.
  • 23. Ming M, Guanhua L, Zhanhai Y, Guang C, Xuan Z. Effect of the Lycium barbarum polysaccharides administration on blood lipid metabolism and oxidative stress of mice fed high-fat diet in vivo. Food Chem. 2009;113:872-7.
  • 24. Mazaro R, Di Stasi LC, Kempinas WDG. Effects of the hydromethanolic extract of Austroplenckia populnea (Celastraceae) on reproductive parameters of male rats. Contraception. 2002;66:205-9.
  • 25. Wang Y, Zhao H, Sheng X, Gambino PE, Costello B, Bojanowski K. Protective effect of Fructus lycii polysaccharides against time and hyperthermia-induced damage in cultured seminiferous epithelium. J Ethnopharmacol. 2002;82:169-75.
  • 26. Luo Q, Li Z, Huang X, Yan J, Zhang S, Cai YZ. Lycium barbarum polysaccharides: Protective effects against heat-induced damage of rat testes and H2 O2 induced DNA damage in mouse testicular cells and beneficial effect on sexual behavior and reproductive function of hemicastrated rats. Life Sci. 2006;79:613-21.
  • 27. Cai Y, Luo Q, Sun M, Corke H. Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer. Life Sci. 2004;74:2157-84.
  • 28. Panda S, Kar A. Evaluation of the antithyroid, antioxidative and antihyperglycemic activity of scopoletin from Aegle marmelos leaves in hyperthyroid rats. Phytother Res. 2006;20:1103-5.
  • 29. Topaktas M, Rencuzogullari E. Cytogenetic. 2010: Nobel publishing. 22-23.

The Physiological and Genotoxic Effects of Water and Ethanol Extracts of Goji Berry (Lycium barbarum L.) on Model Organisms

Yıl 2017, , 76 - 84, 30.09.2017
https://doi.org/10.5799/jcei.343190

Öz

Objectives: Herbal treatments in particular have a place which cannot be ignored in current
alternative medicine. One of these plants, which has become very well-known recently and
which is widely consumed in Turkey is the Goji berry (Lycium barbarum L.). To investigate the
effects of Goji berry, on fertility when used by individuals in their 20s and on physical growth
when used by those of a younger age. It was also aimed to test the genotoxic effects of the Goji
berry on Allium cepa L. meristem stem cells.
Materials and Methods: Goji berry water and ethanol extracts were tested on a model
organism of Caenorhabditis elegans (C. elegans) in respect of fertility and physical growth.
Allium cepa L. meristem stem cells exposed to Goji berry extract were examined for genotoxic
effects.
Results: A significant dose-related reduction was determined in fertility, physical growth and
mitotic index in ethanol extract. In the water extract, a reduction in fertility was determined at
high doses and an increase with the lowest dose used in the study. No significant effect was
found on physical growth of water extract at any dose.
Conclusion: The results of this study showed negative effects on cell division, fertility and
physical growth of Goji berry, which has been used since ancient times in Chinese medicine and
for which several benefits have been claimed in literature. It must be emphasised that doserelated
side-effects may develop with the use of plants for medicinal purposes. 

Kaynakça

  • 1. Amagase H, Farnsworth NR. A review of botanical characteristics, phytochemistry, clinical relevance in efficacy and safety of Lycium barbarum fruit (Goji). Food Res Int. 2011;44:1702-7.
  • 2. Bryan JK, Casta D, Giese N, Nummy K, Rapp C, Seamon E. Goji (Lyciumspp) in natural standard monograph. 2008. Natural Standard Inc.
  • 3. Dag S, Ozpinar H, Sari M, Ozpinar N. Antimicrobial effect of cola on several microorganisms. Cumhuriyet Sci J. 2015;36 52-9.
  • 4. Potterat O. Goji (Lycium barbarum and L. chinense): phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity. Planta Med. 2010;76 7-19.
  • 5. Fabricant DS, Farnsworth NR. The value of plants used in traditional medicine for drug discovery. Environ Health Perspect. 2001;109:69-78.
  • 6. Chan HC, Chang RCC, Ip AKC, et al. Neuroprotective effects of Lycium barbarum Lynn on protecting retinal ganglion cells in an ocular hypertension model of glaucoma. Expe Neurol. 2007;203:269-73.
  • 7. Chalasani SH, Chronis N, Tsunozaki M, Gray JM, Ramot D, Goodman MB, et al. Corrigendum: Dissecting a circuit for olfactory behaviour in Caenorhabditis elegans. Nature. 2016;533:130
  • 8. Ono K, Ono S. Two distinct myosin II populations coordinate ovulatory contraction of the myoepithelial sheath in the Caenorhabditis elegans somatic gonad. Mol Biol Ccell. 2016:27:1131-42.
  • 9. Ozpinar H, Ozpinar N, Kilicgun H, Dag S, Sari M. Physiological and lifespan alterations in Caenorhabditis elegans exposed to Benzoic acid. SSTB. 2011;7:39-47.
  • 10. Olgun A, Aleksenko T, Pereira-Smith OM, Vassilatis DK. Functional analysis of MRG-1: The ortholog of human MRG15 in Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci. 2005;60:543-8.
  • 11. Turkoglu S. Genotoxicity of five food preservatives tested on root tips of Allium cepa L. Mutat Res Genet Toxicol Environ Mutagen. 2007;626:4- 14.
  • 12. Koelle MR, Horvitz HR. EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. Cell. 1996;84:115-25.
  • 13. Li X, Li X, Zhou A. Evaluation of antioxidant activity of the polysaccharides extracted from Lycium barbarum fruits in vitro. Eur Polym J. 2007;43:488-97.
  • 14. Lin CL, Wang CC, Chang SC, Inbaraj BS, Chen BH. Antioxidative activity of polysaccharide fractions isolated from Lycium barbarum Linnaeus. Int j biol Macromol. 2009;45:146-51.
  • 15. Wu SJ, Ng LT, Lin CC. Antioxidant activities of some common ingredients of traditional chinese medicine, Angelica sinensis, Lycium barbarum and Poria cocos. Phytother Res. 2004;18:1008-12.
  • 16. Chang RCC, So KF. Use of anti-aging herbal medicine, Lycium barbarum, against aging-associated diseases. What do we know so far?. Cell Mol Neurobiol. 2008;28:643-52.
  • 17. Gan L, Zhang SH, Yang XL, Xu HB. Immunomodulation and antitumor activity by a polysaccharide–protein complex from Lycium barbarum. Int Immunopharmacol. 2004;4:563-9.
  • 18. Li P, Xiao B, Chen H, Guo J. Lycium barbarum and tumors in the gastrointestinal tract, in Lycium barbarum and human health. 2015. Springer Netherlands, 2015. p. 85-97.
  • 19. Mao F, Xiao B, Jiang Z, Zhao J, Huang X, Guo J. Anticancer effect of Lycium barbarum polysaccharides on colon cancer cells involves G0/G1 phase arrest. Med Oncol. 2011;28:121-6.
  • 20. Yu MS, Lai CSW, Ho YS, Zee SY, So KF, Yuen WH, el al . Characterization of the effects of anti-aging medicine Fructus lycii on ß-amyloid peptide neurotoxicity. Int J Mol Med. 2007;20:261-8.
  • 21. Yu MS, Leung SKY, Lai SW, Che CM, Zee SY, So KF, et al. Neuroprotective effects of anti-aging oriental medicine Lycium barbarum against β-amyloid peptide neurotoxicity. Exp Gerontol. 2005;40:716-27.
  • 22. Yu MS, Ho YS, So KF, Yuen WH, Chang RCC. Cytoprotective effects of Lycium barbarum against reducing stress on endoplasmic reticulum. Int J Mol Med. 2006;17:1157-62.
  • 23. Ming M, Guanhua L, Zhanhai Y, Guang C, Xuan Z. Effect of the Lycium barbarum polysaccharides administration on blood lipid metabolism and oxidative stress of mice fed high-fat diet in vivo. Food Chem. 2009;113:872-7.
  • 24. Mazaro R, Di Stasi LC, Kempinas WDG. Effects of the hydromethanolic extract of Austroplenckia populnea (Celastraceae) on reproductive parameters of male rats. Contraception. 2002;66:205-9.
  • 25. Wang Y, Zhao H, Sheng X, Gambino PE, Costello B, Bojanowski K. Protective effect of Fructus lycii polysaccharides against time and hyperthermia-induced damage in cultured seminiferous epithelium. J Ethnopharmacol. 2002;82:169-75.
  • 26. Luo Q, Li Z, Huang X, Yan J, Zhang S, Cai YZ. Lycium barbarum polysaccharides: Protective effects against heat-induced damage of rat testes and H2 O2 induced DNA damage in mouse testicular cells and beneficial effect on sexual behavior and reproductive function of hemicastrated rats. Life Sci. 2006;79:613-21.
  • 27. Cai Y, Luo Q, Sun M, Corke H. Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer. Life Sci. 2004;74:2157-84.
  • 28. Panda S, Kar A. Evaluation of the antithyroid, antioxidative and antihyperglycemic activity of scopoletin from Aegle marmelos leaves in hyperthyroid rats. Phytother Res. 2006;20:1103-5.
  • 29. Topaktas M, Rencuzogullari E. Cytogenetic. 2010: Nobel publishing. 22-23.
Toplam 29 adet kaynakça vardır.

Ayrıntılar

Konular Sağlık Kurumları Yönetimi
Bölüm Araştırma Yazısı
Yazarlar

Hülya Özpınar

Necati Özpınar

Savas Karakus

Yayımlanma Tarihi 30 Eylül 2017
Yayımlandığı Sayı Yıl 2017

Kaynak Göster

APA Özpınar, H., Özpınar, N., & Karakus, S. (2017). The Physiological and Genotoxic Effects of Water and Ethanol Extracts of Goji Berry (Lycium barbarum L.) on Model Organisms. Journal of Clinical and Experimental Investigations, 8(3), 76-84. https://doi.org/10.5799/jcei.343190
AMA Özpınar H, Özpınar N, Karakus S. The Physiological and Genotoxic Effects of Water and Ethanol Extracts of Goji Berry (Lycium barbarum L.) on Model Organisms. J Clin Exp Invest. Eylül 2017;8(3):76-84. doi:10.5799/jcei.343190
Chicago Özpınar, Hülya, Necati Özpınar, ve Savas Karakus. “The Physiological and Genotoxic Effects of Water and Ethanol Extracts of Goji Berry (Lycium Barbarum L.) on Model Organisms”. Journal of Clinical and Experimental Investigations 8, sy. 3 (Eylül 2017): 76-84. https://doi.org/10.5799/jcei.343190.
EndNote Özpınar H, Özpınar N, Karakus S (01 Eylül 2017) The Physiological and Genotoxic Effects of Water and Ethanol Extracts of Goji Berry (Lycium barbarum L.) on Model Organisms. Journal of Clinical and Experimental Investigations 8 3 76–84.
IEEE H. Özpınar, N. Özpınar, ve S. Karakus, “The Physiological and Genotoxic Effects of Water and Ethanol Extracts of Goji Berry (Lycium barbarum L.) on Model Organisms”, J Clin Exp Invest, c. 8, sy. 3, ss. 76–84, 2017, doi: 10.5799/jcei.343190.
ISNAD Özpınar, Hülya vd. “The Physiological and Genotoxic Effects of Water and Ethanol Extracts of Goji Berry (Lycium Barbarum L.) on Model Organisms”. Journal of Clinical and Experimental Investigations 8/3 (Eylül 2017), 76-84. https://doi.org/10.5799/jcei.343190.
JAMA Özpınar H, Özpınar N, Karakus S. The Physiological and Genotoxic Effects of Water and Ethanol Extracts of Goji Berry (Lycium barbarum L.) on Model Organisms. J Clin Exp Invest. 2017;8:76–84.
MLA Özpınar, Hülya vd. “The Physiological and Genotoxic Effects of Water and Ethanol Extracts of Goji Berry (Lycium Barbarum L.) on Model Organisms”. Journal of Clinical and Experimental Investigations, c. 8, sy. 3, 2017, ss. 76-84, doi:10.5799/jcei.343190.
Vancouver Özpınar H, Özpınar N, Karakus S. The Physiological and Genotoxic Effects of Water and Ethanol Extracts of Goji Berry (Lycium barbarum L.) on Model Organisms. J Clin Exp Invest. 2017;8(3):76-84.