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Pregabalin Intoxication-Induced Prolonged PR Interval on Electrocardiogram

Cilt: 9 Sayı: 2 13 Haziran 2018
  • Erdinç Şengüldür
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Pregabalin Intoxication-Induced Prolonged PR Interval on Electrocardiogram

Öz

Pregabalin is a lipophilic analogue of gamma-aminobutyric acid (GABA) and has a similar
chemical structure to gabapentin and is more potent than gabapentin. This report documents
the case of a 28-year-old male presenting with suicidal attempt by pregabalin intake. The
patient had an abnormal PR interval (reversible AV-block). He was managed with general
supportive care and symptomatic approach such as discontinuation of the drug, hydration with
IV fluids, oxygenation, gastric lavage and activated charcoal administration.

Anahtar Kelimeler

Kaynakça

  1. 1. Evoy KE, Morrison MD, Saklad SR. Abuse and misuse of pregabalin and gabapentin. Drugs. 2017; 77: 403-26.
  2. 2. Milicevic C, Crnobaric C, Nikolic S, Lecic-Tosevski D. A case of pregabalin intoxication. Psychiatriki. 2012;23:162-5.
  3. 3. Ben-Menachem E. Pregabalin pharmacology and its relevance to clinical practice. Epilepsia. 2004;45:13-18.
  4. 4. Aksakal E, Bakırcı E, Emet M. Complete atrioventricular block due to overdose of pregabalin. Am J Emerg Med. 2012;30:2101.
  5. 5. Randinitis EJ, Posvar EL, Alvey CW, Sedman AJ, Cook JA, Bockbrader HN. Pharmacokinetics of pregabalin in subjects with various degrees of renal function. J Clin Pharmacol. 2003;43:277-83.
  6. 6. De Smedt RHE, Jaarsma T, van den Broek SAJ, Haaijer-Ruskamp FM. Decompensation of chronic heart failure associatedwith pregabalin in a 73-year-old patient withpostherpetic neuralgia: a case report. Br J Clin Pharmacol. 2008;66:327-8. 7. De Smedt RHE, Jaarsma T, van den Broek SAJ, Haaijer-Ruskamp FM. Decompensation of chronic heart failure associatedwith pregabalin in a 73-year-old patient withpostherpetic neuralgia: a case report. Br J Clin Pharmacol. 2008;66:327-8.
  7. 8. Belli E, Erkalp K, Yangın Z, Fadıllıoğlu S, Alagöl A. A new analgesic drug: pregabalin and the first intoxications. Agri. 2013; 25: 187-9.

Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Olgu Sunumu

Yazarlar

Erdinç Şengüldür Bu kişi benim

Yayımlanma Tarihi

13 Haziran 2018

Gönderilme Tarihi

17 Ocak 2018

Kabul Tarihi

7 Mayıs 2018

Yayımlandığı Sayı

Yıl 2018 Cilt: 9 Sayı: 2

Kaynak Göster

APA
Şengüldür, E. (2018). Pregabalin Intoxication-Induced Prolonged PR Interval on Electrocardiogram. Journal of Clinical and Experimental Investigations, 9(2), 100-102. https://doi.org/10.5799/jcei.433821
AMA
1.Şengüldür E. Pregabalin Intoxication-Induced Prolonged PR Interval on Electrocardiogram. J Clin Exp Invest. 2018;9(2):100-102. doi:10.5799/jcei.433821
Chicago
Şengüldür, Erdinç. 2018. “Pregabalin Intoxication-Induced Prolonged PR Interval on Electrocardiogram”. Journal of Clinical and Experimental Investigations 9 (2): 100-102. https://doi.org/10.5799/jcei.433821.
EndNote
Şengüldür E (01 Haziran 2018) Pregabalin Intoxication-Induced Prolonged PR Interval on Electrocardiogram. Journal of Clinical and Experimental Investigations 9 2 100–102.
IEEE
[1]E. Şengüldür, “Pregabalin Intoxication-Induced Prolonged PR Interval on Electrocardiogram”, J Clin Exp Invest, c. 9, sy 2, ss. 100–102, Haz. 2018, doi: 10.5799/jcei.433821.
ISNAD
Şengüldür, Erdinç. “Pregabalin Intoxication-Induced Prolonged PR Interval on Electrocardiogram”. Journal of Clinical and Experimental Investigations 9/2 (01 Haziran 2018): 100-102. https://doi.org/10.5799/jcei.433821.
JAMA
1.Şengüldür E. Pregabalin Intoxication-Induced Prolonged PR Interval on Electrocardiogram. J Clin Exp Invest. 2018;9:100–102.
MLA
Şengüldür, Erdinç. “Pregabalin Intoxication-Induced Prolonged PR Interval on Electrocardiogram”. Journal of Clinical and Experimental Investigations, c. 9, sy 2, Haziran 2018, ss. 100-2, doi:10.5799/jcei.433821.
Vancouver
1.Erdinç Şengüldür. Pregabalin Intoxication-Induced Prolonged PR Interval on Electrocardiogram. J Clin Exp Invest. 01 Haziran 2018;9(2):100-2. doi:10.5799/jcei.433821