Prognostic Value of Mean Platelet Volume and Platelet to Lymphocyte Ratio in Laryngeal Carcinoma

Yıl 2016, Cilt: 7 Sayı: 2, 134 - 138, 16.06.2016

Beyhan Yılmaz

https://doi.org/10.5799/ahinjs.01.2016.02.0585

Cited By: 3

Öz

Objective: In this study, we aimed to investigate
whether platelet lymphocyte ratio (PLR) and Mean platelet volume (MPV)
values can be used as prognostic and diagnostic markers in laryngeal
cancer.

Methods: A total of 242 patients with laryngeal
pathology were reviewed retrospectively. PLR, MPV and platelet values
were compared in patients with benign and malignant pathologies. The
correlation of PLR, MPV and platelet values of patients with malignant
pathologies with their age, gender, smoking, alcohol use, degree of
differentiation, and clinical stage was investigated.

Results: The PLR values were significantly higher in
smokers (p=0.009), alcohol drinkers (p=0.001), clinical stage IV
patients (p=0.001), and patients with poor differentiated laryngeal
cancer (p=0.001), compared to nonsmokers, non­alcohol consumers,
clinical stage III patients, and patients with well-differentiated
laryngeal cancer. MPV values were significantly lower in patients with
clinical stage IV (p=0.018), and poor differentiated (p=0.010),
laryngeal cancer com­pared to patients with clinical stage III and
well-differentiated laryngeal cancer. The PLR value was significantly
higher in the malignant group than in the benign group (p<0.001).

Conclusion: Our results showed that PLR values can be
used as diagnostic and prognostic factors and MPV values can be used as
prognostic factors in laryngeal cancer. J Clin Exp Invest 2016; 7 (2): 134-138

Anahtar Kelimeler

Platelet-lymphocyte ratio, mean platelet volume, prognostic marker, diagnostic marker, laryngeal carcinoma

Kaynakça

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