Multipl Myelomda Yeni Ajanlarla Güncel Tedavi Yaklaşımları

Yıl 2018, Cilt: 9 Sayı: 2, 103 - 112, 13.06.2018

Senem Maral

https://doi.org/10.5799/jcei.433823

Öz

Multipl myelom kemik iliğinde anormal plazma hücre artışı ve immunglobulin veya hafif zincir

aşırı üretimi nedeniyle organ hasarı ile sonuçlanabilen malign bir hastalıktır. Hetereojen bir

hastalık olan myelomda kolay tolere edilen bir rejim ile mümkün olan en az toksisiteyle, hızlı ve

etkin şekilde hastalığı kontrol altına almak, hastalık ilişkili komplikasyonları düzeltmek ve

önlemek, erken ölüm riskini azaltmak hedeflenmektedir. Son yıllarda multipl myelom tedavisinde

çok sayıda yeni nesil ajanın hızla tedavi pratiğine eklenmesi ile hastaların sağ kalım süresi

dramatik şekilde uzamıştır. Mevcut tedaviler sağ kalım ve hastalıksız yaşam süresine olumlu

katkı sağlamakla birlikte, hastalık nüksünü engelleyememektedir. Halihazırda otolog kök hücre

nakli tedavideki yerini korumaktaysa da yeni nesil ajanlar ile gelecek için umut vaad etmektedir.

Anahtar Kelimeler

Multipl myelom, proteozom inhibitörleri, monoklonal antikorlar, immun modulatörler, histondeasetilaz inhibitörler

Kaynakça

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